Motif ID: Stat2

Z-value: 2.251


Transcription factors associated with Stat2:

Gene SymbolEntrez IDGene Name
Stat2 ENSMUSG00000040033.9 Stat2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat2mm10_v2_chr10_+_128270546_1282705770.541.3e-06Click!


Activity profile for motif Stat2.

activity profile for motif Stat2


Sorted Z-values histogram for motif Stat2

Sorted Z-values for motif Stat2



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_103434211 32.108 ENSMUST00000079294.5
ENSMUST00000076788.5
ENSMUST00000076702.5
ENSMUST00000066701.6
ENSMUST00000085065.5
ENSMUST00000140838.1
Ifi27





interferon, alpha-inducible protein 27





chr7_-_141010759 28.683 ENSMUST00000026565.6
Ifitm3
interferon induced transmembrane protein 3
chr1_-_173942445 23.436 ENSMUST00000042228.8
ENSMUST00000081216.5
ENSMUST00000129829.1
ENSMUST00000123708.1
ENSMUST00000111210.2
Ifi203



Mndal
interferon activated gene 203



myeloid nuclear differentiation antigen like
chr6_+_90550789 20.129 ENSMUST00000130418.1
ENSMUST00000032175.8
Aldh1l1

aldehyde dehydrogenase 1 family, member L1

chr16_+_23609895 16.479 ENSMUST00000038423.5
Rtp4
receptor transporter protein 4
chr8_-_84773381 14.536 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr16_+_42907563 13.638 ENSMUST00000151244.1
ENSMUST00000114694.2
Zbtb20

zinc finger and BTB domain containing 20

chr3_-_107760221 13.364 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
Csf1


colony stimulating factor 1 (macrophage)


chr6_-_39118211 13.062 ENSMUST00000038398.6
Parp12
poly (ADP-ribose) polymerase family, member 12
chr16_+_26581704 12.688 ENSMUST00000096129.2
ENSMUST00000166294.2
ENSMUST00000174202.1
ENSMUST00000023156.6
Il1rap



interleukin 1 receptor accessory protein



chr1_+_153751946 12.221 ENSMUST00000183241.1
Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
chr6_+_121245903 12.167 ENSMUST00000032198.9
Usp18
ubiquitin specific peptidase 18
chr2_-_51972990 12.056 ENSMUST00000145481.1
ENSMUST00000112705.2
Nmi

N-myc (and STAT) interactor

chr1_+_153751859 11.814 ENSMUST00000182538.1
Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
chr16_+_43363855 11.347 ENSMUST00000156367.1
Zbtb20
zinc finger and BTB domain containing 20
chr3_+_81932601 11.223 ENSMUST00000029649.2
Ctso
cathepsin O
chrX_+_166238901 10.303 ENSMUST00000112235.1
Gpm6b
glycoprotein m6b
chr1_-_156674290 10.254 ENSMUST00000079625.4
Tor3a
torsin family 3, member A
chr11_+_119393060 10.209 ENSMUST00000131035.2
ENSMUST00000093902.5
Rnf213

ring finger protein 213

chr1_-_170110491 9.997 ENSMUST00000027985.2
Ddr2
discoidin domain receptor family, member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 65.9 GO:0035456 response to interferon-beta(GO:0035456)
1.7 45.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
2.8 42.7 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.7 32.9 GO:0046825 regulation of protein export from nucleus(GO:0046825)
4.1 20.6 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
6.7 20.1 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.4 18.0 GO:0001919 regulation of receptor recycling(GO:0001919)
5.5 16.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
1.0 14.8 GO:0034340 response to type I interferon(GO:0034340)
4.9 14.7 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
1.0 14.5 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
3.3 13.1 GO:0044565 dendritic cell proliferation(GO:0044565)
1.6 12.7 GO:0072602 interleukin-4 secretion(GO:0072602)
4.0 12.1 GO:1902524 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) negative regulation of interferon-beta biosynthetic process(GO:0045358) positive regulation of protein K48-linked ubiquitination(GO:1902524)
2.0 11.8 GO:0010528 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
2.9 11.6 GO:0009597 detection of virus(GO:0009597)
1.5 10.3 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
1.3 10.2 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
1.4 10.0 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.7 9.7 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 71.2 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 49.2 GO:0016021 integral component of membrane(GO:0016021)
0.4 44.9 GO:0016363 nuclear matrix(GO:0016363)
0.0 37.7 GO:0005634 nucleus(GO:0005634)
0.7 32.1 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 29.5 GO:0005739 mitochondrion(GO:0005739)
0.0 25.7 GO:0005654 nucleoplasm(GO:0005654)
0.1 20.6 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
1.6 18.0 GO:0043083 synaptic cleft(GO:0043083)
0.3 15.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
4.5 13.4 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 13.2 GO:0005730 nucleolus(GO:0005730)
0.0 12.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 12.0 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 11.7 GO:0016324 apical plasma membrane(GO:0016324)
0.1 11.6 GO:0032587 ruffle membrane(GO:0032587)
0.0 11.4 GO:0005667 transcription factor complex(GO:0005667)
0.9 9.5 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.0 8.1 GO:0043235 receptor complex(GO:0043235)
1.1 7.5 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 62.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
3.3 42.7 GO:0016443 bidentate ribonuclease III activity(GO:0016443)
1.4 32.1 GO:0005521 lamin binding(GO:0005521)
0.1 28.0 GO:0005525 GTP binding(GO:0005525)
0.1 24.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
1.1 22.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
5.1 20.6 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
6.7 20.1 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
2.6 18.0 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 14.6 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.2 13.7 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 13.4 GO:0008083 growth factor activity(GO:0008083)
0.2 13.2 GO:0033613 activating transcription factor binding(GO:0033613)
1.0 12.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
1.2 12.2 GO:0016920 pyroglutamyl-peptidase activity(GO:0016920)
2.9 11.8 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.2 10.9 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 10.3 GO:0016836 hydro-lyase activity(GO:0016836)
1.1 10.0 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.3 9.5 GO:0070412 R-SMAD binding(GO:0070412)