Motif ID: Stat4_Stat3_Stat5b

Z-value: 0.873

Transcription factors associated with Stat4_Stat3_Stat5b:

Gene SymbolEntrez IDGene Name
Stat3 ENSMUSG00000004040.10 Stat3
Stat4 ENSMUSG00000062939.5 Stat4
Stat5b ENSMUSG00000020919.5 Stat5b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat4mm10_v2_chr1_+_51987139_51987151-0.771.0e-14Click!
Stat3mm10_v2_chr11_-_100939357_1009394560.362.4e-03Click!
Stat5bmm10_v2_chr11_-_100822525_100822576-0.334.6e-03Click!


Activity profile for motif Stat4_Stat3_Stat5b.

activity profile for motif Stat4_Stat3_Stat5b


Sorted Z-values histogram for motif Stat4_Stat3_Stat5b

Sorted Z-values for motif Stat4_Stat3_Stat5b



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat4_Stat3_Stat5b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_80802789 16.736 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chrX_-_61185558 14.703 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr4_-_64046925 9.958 ENSMUST00000107377.3
 Tnc
tenascin C
chr17_+_26715644 6.655 ENSMUST00000062519.7
ENSMUST00000144221.1
ENSMUST00000142539.1
ENSMUST00000151681.1
 Crebrf



CREB3 regulatory factor



chr6_+_115134899 6.071 ENSMUST00000009538.5
ENSMUST00000169345.1
 Syn2

synapsin II

chr10_-_95417099 5.737 ENSMUST00000135822.1
 Socs2
suppressor of cytokine signaling 2
chr4_+_148602527 5.164 ENSMUST00000105701.2
ENSMUST00000052060.6
 Masp2

mannan-binding lectin serine peptidase 2

chr16_-_23988852 5.075 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr16_-_74411292 4.967 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chr16_-_74411776 4.740 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr8_-_124569696 4.425 ENSMUST00000063278.6
 Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr10_-_95416850 4.382 ENSMUST00000020215.9
 Socs2
suppressor of cytokine signaling 2
chr12_+_11265867 4.203 ENSMUST00000020931.5
 Smc6
structural maintenance of chromosomes 6
chr9_+_107296843 4.044 ENSMUST00000167072.1
 Cish
cytokine inducible SH2-containing protein
chr19_-_46327121 3.840 ENSMUST00000041391.4
ENSMUST00000096029.5
 Psd

pleckstrin and Sec7 domain containing

chr10_+_13966268 3.773 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr5_+_88886809 3.611 ENSMUST00000148750.1
 Slc4a4
solute carrier family 4 (anion exchanger), member 4
chr13_-_67755132 3.554 ENSMUST00000091520.6
 Zfp85-rs1
zinc finger protein 85, related sequence 1
chr5_+_14025305 3.470 ENSMUST00000073957.6
 Sema3e
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr7_-_78577771 3.455 ENSMUST00000039438.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 215 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 15.0 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
2.5 10.0 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
3.2 9.7 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.5 9.7 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.3 6.8 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
1.3 6.7 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.1 6.7 GO:0060612 adipose tissue development(GO:0060612)
0.1 6.3 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.2 6.2 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.1 6.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
1.9 5.8 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
0.5 5.7 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 5.5 GO:0048813 dendrite morphogenesis(GO:0048813)
0.0 5.3 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.7 5.2 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
1.7 5.1 GO:0043379 memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.2 4.5 GO:0034340 response to type I interferon(GO:0034340)
0.2 4.3 GO:0061157 mRNA destabilization(GO:0061157)
0.1 4.0 GO:0001953 negative regulation of cell-matrix adhesion(GO:0001953)
0.6 3.9 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 16.7 GO:0032279 asymmetric synapse(GO:0032279)
0.6 9.8 GO:0005614 interstitial matrix(GO:0005614)
0.3 9.7 GO:0030673 axolemma(GO:0030673)
0.0 7.7 GO:0016604 nuclear body(GO:0016604)
0.0 7.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 6.6 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2 5.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.3 5.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
1.4 4.2 GO:0035061 interchromatin granule(GO:0035061)
0.1 4.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.5 3.6 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.2 3.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 3.3 GO:0034451 centriolar satellite(GO:0034451)
0.8 3.2 GO:0031673 H zone(GO:0031673)
0.2 3.0 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 3.0 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 2.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 2.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 2.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.7 2.8 GO:0090537 CERF complex(GO:0090537)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 156 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 16.7 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
2.1 10.7 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
1.7 10.0 GO:0045545 syndecan binding(GO:0045545)
0.1 9.8 GO:0004860 protein kinase inhibitor activity(GO:0004860)
1.2 9.7 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 7.0 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.2 6.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.8 6.2 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 6.2 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 6.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
1.3 5.2 GO:0004528 phosphodiesterase I activity(GO:0004528)
1.0 5.2 GO:0016972 thiol oxidase activity(GO:0016972)
0.4 4.7 GO:0001846 opsonin binding(GO:0001846)
0.4 4.4 GO:0048018 receptor agonist activity(GO:0048018)
1.0 3.9 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.1 3.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.2 3.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.2 3.6 GO:0051787 misfolded protein binding(GO:0051787)
0.7 3.5 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.4 3.5 GO:0038191 neuropilin binding(GO:0038191)