Motif ID: Stat6

Z-value: 1.089


Transcription factors associated with Stat6:

Gene SymbolEntrez IDGene Name
Stat6 ENSMUSG00000002147.12 Stat6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat6mm10_v2_chr10_+_127642975_1276430340.326.1e-03Click!


Activity profile for motif Stat6.

activity profile for motif Stat6


Sorted Z-values histogram for motif Stat6

Sorted Z-values for motif Stat6



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat6

PNG image of the network

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Top targets:


Showing 1 to 20 of 133 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_136143497 17.318 ENSMUST00000008016.2
Id3
inhibitor of DNA binding 3
chr9_-_70421533 14.639 ENSMUST00000034742.6
Ccnb2
cyclin B2
chr11_-_55419898 13.215 ENSMUST00000108858.1
ENSMUST00000141530.1
Sparc

secreted acidic cysteine rich glycoprotein

chr18_+_50053282 12.841 ENSMUST00000148159.2
Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr11_-_102579461 12.789 ENSMUST00000107081.1
Gm11627
predicted gene 11627
chr1_-_120121030 11.492 ENSMUST00000027634.6
Dbi
diazepam binding inhibitor
chr18_-_15403680 11.325 ENSMUST00000079081.6
Aqp4
aquaporin 4
chr15_-_82244716 10.966 ENSMUST00000089155.4
ENSMUST00000089157.3
Cenpm

centromere protein M

chr2_-_113848655 10.395 ENSMUST00000102545.1
ENSMUST00000110948.1
Arhgap11a

Rho GTPase activating protein 11A

chr2_-_113848601 10.110 ENSMUST00000110949.2
Arhgap11a
Rho GTPase activating protein 11A
chr1_+_146497614 9.865 ENSMUST00000132847.1
ENSMUST00000166814.1
Brinp3

bone morphogenetic protein/retinoic acid inducible neural specific 3

chr10_-_78591945 9.733 ENSMUST00000040580.6
Syde1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr17_-_89910449 8.945 ENSMUST00000086423.4
Gm10184
predicted pseudogene 10184
chr2_+_163225363 8.732 ENSMUST00000099110.3
ENSMUST00000165937.1
Tox2

TOX high mobility group box family member 2

chr4_+_116708467 8.695 ENSMUST00000030452.6
Ccdc163
coiled-coil domain containing 163
chr2_-_51972990 8.017 ENSMUST00000145481.1
ENSMUST00000112705.2
Nmi

N-myc (and STAT) interactor

chr15_+_32920723 7.877 ENSMUST00000022871.5
Sdc2
syndecan 2
chr14_-_21989475 7.819 ENSMUST00000043409.7
Zfp503
zinc finger protein 503
chr2_-_147186389 7.714 ENSMUST00000109970.3
ENSMUST00000067075.5
Nkx2-2

NK2 homeobox 2

chr11_-_60220550 7.523 ENSMUST00000020846.1
Srebf1
sterol regulatory element binding transcription factor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 17.3 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.3 15.4 GO:0071300 cellular response to retinoic acid(GO:0071300)
1.9 13.1 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.2 12.8 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
0.3 12.5 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.3 12.5 GO:0043029 T cell homeostasis(GO:0043029)
0.2 11.8 GO:0051489 regulation of filopodium assembly(GO:0051489)
2.3 11.5 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
1.1 11.5 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
2.3 11.3 GO:0070295 renal water absorption(GO:0070295)
0.7 10.7 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
1.2 9.7 GO:0016081 synaptic vesicle docking(GO:0016081)
2.7 8.0 GO:1902524 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) negative regulation of interferon-beta biosynthetic process(GO:0045358) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.1 7.9 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
2.6 7.8 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
2.6 7.7 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.9 7.5 GO:0003062 regulation of heart rate by chemical signal(GO:0003062)
0.5 7.3 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 6.7 GO:0010631 epithelial cell migration(GO:0010631)
0.1 6.5 GO:0007032 endosome organization(GO:0007032)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 31.0 GO:0005654 nucleoplasm(GO:0005654)
0.0 26.6 GO:0005813 centrosome(GO:0005813)
3.3 13.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.3 13.1 GO:0048786 presynaptic active zone(GO:0048786)
0.2 11.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.8 11.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.4 11.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 11.3 GO:0009925 basal plasma membrane(GO:0009925)
0.1 11.0 GO:0000776 kinetochore(GO:0000776)
0.5 9.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 7.8 GO:0005768 endosome(GO:0005768)
0.1 5.3 GO:0016459 myosin complex(GO:0016459)
0.0 5.3 GO:0005884 actin filament(GO:0005884)
0.0 5.1 GO:0005802 trans-Golgi network(GO:0005802)
0.3 4.7 GO:0005922 connexon complex(GO:0005922)
0.8 4.2 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 3.5 GO:0005801 cis-Golgi network(GO:0005801)
0.1 3.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 2.8 GO:0000922 spindle pole(GO:0000922)
0.3 2.5 GO:0045298 tubulin complex(GO:0045298)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 15.5 GO:0050840 extracellular matrix binding(GO:0050840)
1.9 13.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.3 12.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 12.7 GO:0005096 GTPase activator activity(GO:0005096)
1.2 11.6 GO:0042301 phosphate ion binding(GO:0042301)
2.9 11.5 GO:0030156 benzodiazepine receptor binding(GO:0030156)
1.9 11.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
1.6 11.3 GO:0015288 porin activity(GO:0015288)
0.3 10.9 GO:0030332 cyclin binding(GO:0030332)
0.1 10.8 GO:0051015 actin filament binding(GO:0051015)
0.3 10.7 GO:0005504 fatty acid binding(GO:0005504)
0.2 8.1 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 7.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.4 7.3 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2 6.7 GO:0004697 protein kinase C activity(GO:0004697)
0.1 6.7 GO:0030507 spectrin binding(GO:0030507)
0.1 6.6 GO:0005179 hormone activity(GO:0005179)
1.4 5.7 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.1 5.4 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 5.3 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)