Motif ID: Tbr1

Z-value: 1.087


Transcription factors associated with Tbr1:

Gene SymbolEntrez IDGene Name
Tbr1 ENSMUSG00000035033.9 Tbr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbr1mm10_v2_chr2_+_61804453_61804538-0.721.7e-12Click!


Activity profile for motif Tbr1.

activity profile for motif Tbr1


Sorted Z-values histogram for motif Tbr1

Sorted Z-values for motif Tbr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_120899067 13.423 ENSMUST00000092143.5
Msrb3
methionine sulfoxide reductase B3
chr2_+_71528657 10.949 ENSMUST00000126400.1
Dlx1
distal-less homeobox 1
chr10_+_57784859 10.533 ENSMUST00000020024.5
Fabp7
fatty acid binding protein 7, brain
chr9_-_43239816 9.646 ENSMUST00000034512.5
Oaf
OAF homolog (Drosophila)
chr3_-_115715031 9.580 ENSMUST00000055676.2
S1pr1
sphingosine-1-phosphate receptor 1
chr3_-_145649970 9.058 ENSMUST00000029846.3
Cyr61
cysteine rich protein 61
chr2_-_71546745 8.524 ENSMUST00000024159.6
Dlx2
distal-less homeobox 2
chrX_+_96455359 8.304 ENSMUST00000033553.7
Heph
hephaestin
chr2_+_71529085 7.904 ENSMUST00000152711.1
Dlx1
distal-less homeobox 1
chr17_+_34263209 7.787 ENSMUST00000040828.5
H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr6_-_94700137 7.118 ENSMUST00000101126.2
ENSMUST00000032105.4
Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr7_-_144939823 7.073 ENSMUST00000093962.4
Ccnd1
cyclin D1
chr9_-_21760275 7.034 ENSMUST00000098942.4
Spc24
SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr12_+_85473883 6.880 ENSMUST00000021674.6
Fos
FBJ osteosarcoma oncogene
chr8_+_45885479 6.807 ENSMUST00000034053.5
Pdlim3
PDZ and LIM domain 3
chr12_+_109459843 6.703 ENSMUST00000173812.1
Dlk1
delta-like 1 homolog (Drosophila)
chr10_+_57784914 6.697 ENSMUST00000165013.1
Fabp7
fatty acid binding protein 7, brain
chr17_+_87635974 6.690 ENSMUST00000053577.8
Epcam
epithelial cell adhesion molecule
chr9_-_106199253 6.546 ENSMUST00000140761.1
Ppm1m
protein phosphatase 1M
chr3_-_157925056 6.403 ENSMUST00000118539.1
Cth
cystathionase (cystathionine gamma-lyase)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 325 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.1 27.4 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
1.1 17.3 GO:0060134 prepulse inhibition(GO:0060134)
2.3 11.7 GO:0030091 protein repair(GO:0030091)
3.3 10.0 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
1.6 9.9 GO:0045218 zonula adherens maintenance(GO:0045218)
3.2 9.6 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
3.0 9.1 GO:0030421 defecation(GO:0030421)
3.0 9.1 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.4 8.8 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.2 8.7 GO:0035690 cellular response to drug(GO:0035690)
1.4 8.6 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
2.8 8.3 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
0.4 8.3 GO:0006825 copper ion transport(GO:0006825)
0.2 8.3 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
2.0 8.2 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
2.6 7.8 GO:1903232 melanosome assembly(GO:1903232)
1.9 7.8 GO:0002339 B cell selection(GO:0002339)
0.9 7.5 GO:0051255 spindle midzone assembly(GO:0051255)
2.4 7.1 GO:0032474 otolith morphogenesis(GO:0032474)
1.0 7.1 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 151 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 21.6 GO:0005667 transcription factor complex(GO:0005667)
0.1 16.4 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 14.3 GO:0005604 basement membrane(GO:0005604)
0.0 13.0 GO:0005925 focal adhesion(GO:0005925)
0.1 12.5 GO:0030027 lamellipodium(GO:0030027)
0.2 12.0 GO:0005871 kinesin complex(GO:0005871)
0.9 9.9 GO:0005915 zonula adherens(GO:0005915)
0.2 9.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 8.9 GO:0001750 photoreceptor outer segment(GO:0001750)
0.3 8.4 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
2.7 8.1 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.7 8.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
1.1 7.8 GO:0042613 MHC class II protein complex(GO:0042613)
0.4 7.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 7.1 GO:0015934 large ribosomal subunit(GO:0015934)
1.2 7.0 GO:0031262 Ndc80 complex(GO:0031262)
1.3 6.6 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.7 6.5 GO:0042575 DNA polymerase complex(GO:0042575)
0.8 6.1 GO:0070652 HAUS complex(GO:0070652)
0.4 6.1 GO:0035686 sperm fibrous sheath(GO:0035686)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 229 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 21.2 GO:0004364 glutathione transferase activity(GO:0004364)
0.5 15.5 GO:0005504 fatty acid binding(GO:0005504)
0.2 15.4 GO:0033613 activating transcription factor binding(GO:0033613)
1.9 13.4 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
1.5 12.1 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
1.9 11.2 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 11.1 GO:0003727 single-stranded RNA binding(GO:0003727)
1.2 10.8 GO:0015643 toxic substance binding(GO:0015643)
0.4 10.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.8 9.9 GO:0070097 delta-catenin binding(GO:0070097)
1.2 9.3 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.4 9.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
1.7 8.6 GO:0017108 5'-flap endonuclease activity(GO:0017108)
1.7 8.3 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 8.0 GO:0043565 sequence-specific DNA binding(GO:0043565)
2.6 7.8 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.6 7.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 7.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 7.1 GO:0070064 proline-rich region binding(GO:0070064)
0.1 7.0 GO:0048487 beta-tubulin binding(GO:0048487)