Motif ID: Tbx1_Eomes

Z-value: 0.792

Transcription factors associated with Tbx1_Eomes:

Gene SymbolEntrez IDGene Name
Eomes ENSMUSG00000032446.8 Eomes
Tbx1 ENSMUSG00000009097.9 Tbx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Eomesmm10_v2_chr9_+_118478344_1184784510.508.8e-06Click!


Activity profile for motif Tbx1_Eomes.

activity profile for motif Tbx1_Eomes


Sorted Z-values histogram for motif Tbx1_Eomes

Sorted Z-values for motif Tbx1_Eomes



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx1_Eomes

PNG image of the network

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Top targets:


Showing 1 to 20 of 145 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 11.955 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr1_+_6730051 11.691 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr4_+_125490688 9.766 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr2_-_13011747 9.319 ENSMUST00000061545.5
 C1ql3
C1q-like 3
chr1_-_138847579 8.418 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr9_-_43239816 7.611 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr6_-_94700137 7.212 ENSMUST00000101126.2
ENSMUST00000032105.4
 Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr7_-_28302238 6.948 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr1_+_6730135 6.825 ENSMUST00000155921.1
 St18
suppression of tumorigenicity 18
chrX_+_100729917 6.005 ENSMUST00000019503.7
 Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr6_+_15196949 5.327 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
 Foxp2



forkhead box P2



chrX_+_100730178 5.228 ENSMUST00000113744.1
 Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr17_+_29093763 4.903 ENSMUST00000023829.6
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr7_-_100658394 4.650 ENSMUST00000138830.1
ENSMUST00000107044.3
ENSMUST00000116287.2
 Plekhb1


pleckstrin homology domain containing, family B (evectins) member 1


chr14_+_62292475 3.954 ENSMUST00000166879.1
 Rnaseh2b
ribonuclease H2, subunit B
chr12_+_3891728 3.703 ENSMUST00000172689.1
ENSMUST00000111186.1
 Dnmt3a

DNA methyltransferase 3A

chr18_-_46212595 3.558 ENSMUST00000037011.4
 Trim36
tripartite motif-containing 36
chr9_-_95845215 3.509 ENSMUST00000093800.2
 Pls1
plastin 1 (I-isoform)
chr1_+_153665274 3.403 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8

chr6_-_24956106 3.339 ENSMUST00000127247.2
 Tmem229a
transmembrane protein 229A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 11.2 GO:0090527 actin filament reorganization(GO:0090527)
0.1 10.7 GO:0050807 regulation of synapse organization(GO:0050807)
0.9 10.3 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.9 9.8 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
1.7 8.4 GO:0035262 gonad morphogenesis(GO:0035262)
2.4 7.2 GO:0032474 otolith morphogenesis(GO:0032474)
1.4 6.9 GO:0007386 compartment pattern specification(GO:0007386)
0.4 5.3 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.2 5.0 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.5 4.9 GO:0071493 cellular response to UV-B(GO:0071493) replicative senescence(GO:0090399)
0.2 4.0 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.5 3.7 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.1 3.6 GO:0007340 acrosome reaction(GO:0007340)
1.2 3.5 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
1.2 3.5 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 3.1 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.7 3.0 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.3 2.9 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.9 2.8 GO:2000852 regulation of corticosterone secretion(GO:2000852)
0.2 2.7 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.2 GO:0005884 actin filament(GO:0005884)
0.3 10.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.3 10.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 9.3 GO:0005581 collagen trimer(GO:0005581)
0.1 7.2 GO:0001750 photoreceptor outer segment(GO:0001750)
1.6 4.9 GO:0070557 PCNA-p21 complex(GO:0070557)
0.3 4.7 GO:0005922 connexon complex(GO:0005922)
0.7 4.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.2 3.7 GO:0001741 XY body(GO:0001741)
0.0 3.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.7 3.5 GO:1990357 terminal web(GO:1990357)
0.2 3.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 2.7 GO:0031985 Golgi cisterna(GO:0031985)
0.1 2.5 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 2.1 GO:0030018 Z disc(GO:0030018)
0.0 1.7 GO:0005814 centriole(GO:0005814)
0.1 1.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 1.1 GO:0042734 presynaptic membrane(GO:0042734)
0.1 0.9 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 11.2 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.2 10.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
2.0 9.8 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.5 7.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 7.1 GO:0008022 protein C-terminus binding(GO:0008022)
0.2 6.9 GO:0005112 Notch binding(GO:0005112)
0.1 5.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.5 4.0 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 4.0 GO:0051015 actin filament binding(GO:0051015)
0.5 3.7 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.1 3.2 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
1.0 3.0 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 3.0 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.5 2.7 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 2.7 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 2.6 GO:0008432 JUN kinase binding(GO:0008432)
0.0 2.6 GO:0000287 magnesium ion binding(GO:0000287)
0.3 2.4 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.5 2.3 GO:0071253 connexin binding(GO:0071253)
0.2 2.3 GO:0005243 gap junction channel activity(GO:0005243)