Motif ID: Tbx1_Eomes
Z-value: 0.792
Transcription factors associated with Tbx1_Eomes:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Eomes | ENSMUSG00000032446.8 | Eomes |
Tbx1 | ENSMUSG00000009097.9 | Tbx1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Eomes | mm10_v2_chr9_+_118478344_118478451 | 0.50 | 8.8e-06 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.4 | 7.2 | GO:0032474 | otolith morphogenesis(GO:0032474) |
1.7 | 8.4 | GO:0035262 | gonad morphogenesis(GO:0035262) |
1.4 | 6.9 | GO:0007386 | compartment pattern specification(GO:0007386) |
1.2 | 3.5 | GO:0001951 | intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896) |
1.2 | 3.5 | GO:0061537 | glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537) |
1.1 | 11.2 | GO:0090527 | actin filament reorganization(GO:0090527) |
0.9 | 2.8 | GO:2000852 | regulation of corticosterone secretion(GO:2000852) |
0.9 | 9.8 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
0.9 | 2.6 | GO:0051866 | general adaptation syndrome(GO:0051866) |
0.9 | 10.3 | GO:0060159 | regulation of dopamine receptor signaling pathway(GO:0060159) |
0.8 | 2.3 | GO:0021893 | cerebral cortex GABAergic interneuron fate commitment(GO:0021893) |
0.8 | 2.3 | GO:0003104 | positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643) |
0.7 | 3.0 | GO:0060745 | mammary gland branching involved in pregnancy(GO:0060745) |
0.7 | 2.1 | GO:0090526 | response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
0.5 | 4.9 | GO:0071493 | cellular response to UV-B(GO:0071493) replicative senescence(GO:0090399) |
0.5 | 2.4 | GO:0030091 | protein repair(GO:0030091) |
0.5 | 3.7 | GO:0044027 | hypermethylation of CpG island(GO:0044027) |
0.5 | 1.4 | GO:0060708 | spongiotrophoblast differentiation(GO:0060708) |
0.4 | 5.3 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
0.4 | 1.3 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
0.4 | 2.0 | GO:0007262 | STAT protein import into nucleus(GO:0007262) |
0.4 | 0.7 | GO:0036118 | hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
0.3 | 2.2 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
0.3 | 0.8 | GO:0014005 | microglia differentiation(GO:0014004) microglia development(GO:0014005) |
0.3 | 1.1 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
0.3 | 2.9 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
0.3 | 1.0 | GO:0007412 | axon target recognition(GO:0007412) |
0.2 | 4.0 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
0.2 | 5.0 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
0.2 | 2.6 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
0.2 | 0.6 | GO:1903587 | regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587) |
0.2 | 2.7 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
0.1 | 3.6 | GO:0007340 | acrosome reaction(GO:0007340) |
0.1 | 1.7 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
0.1 | 0.6 | GO:0007171 | cardiac conduction system development(GO:0003161) activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) |
0.1 | 0.6 | GO:0010572 | positive regulation of platelet activation(GO:0010572) |
0.1 | 0.4 | GO:0060830 | ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) |
0.1 | 3.1 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
0.1 | 0.9 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
0.1 | 0.4 | GO:0051697 | protein delipidation(GO:0051697) |
0.1 | 0.5 | GO:0046549 | retinal cone cell development(GO:0046549) |
0.1 | 2.2 | GO:0010842 | retina layer formation(GO:0010842) |
0.1 | 0.5 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
0.1 | 1.1 | GO:0006851 | mitochondrial calcium ion transport(GO:0006851) |
0.1 | 10.7 | GO:0050807 | regulation of synapse organization(GO:0050807) |
0.1 | 1.1 | GO:0038166 | angiotensin-activated signaling pathway(GO:0038166) |
0.1 | 0.4 | GO:0010908 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730) |
0.1 | 0.5 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
0.1 | 0.3 | GO:1905098 | negative regulation of translation in response to stress(GO:0032055) negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
0.0 | 0.4 | GO:0010587 | miRNA catabolic process(GO:0010587) |
0.0 | 0.1 | GO:0015772 | disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772) |
0.0 | 0.5 | GO:0007220 | Notch receptor processing(GO:0007220) |
0.0 | 0.3 | GO:0060134 | prepulse inhibition(GO:0060134) |
0.0 | 2.1 | GO:0008347 | glial cell migration(GO:0008347) |
0.0 | 0.5 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
0.0 | 0.4 | GO:0071318 | cellular response to ATP(GO:0071318) |
0.0 | 0.7 | GO:0034453 | microtubule anchoring(GO:0034453) |
0.0 | 0.2 | GO:0040031 | snRNA modification(GO:0040031) |
0.0 | 0.4 | GO:0060481 | lobar bronchus epithelium development(GO:0060481) |
0.0 | 0.2 | GO:0006297 | nucleotide-excision repair, DNA gap filling(GO:0006297) |
0.0 | 0.8 | GO:0006270 | DNA replication initiation(GO:0006270) |
0.0 | 1.1 | GO:0006493 | protein O-linked glycosylation(GO:0006493) |
0.0 | 0.4 | GO:0035873 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879) |
0.0 | 0.2 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
0.0 | 0.9 | GO:0021884 | forebrain neuron development(GO:0021884) |
0.0 | 2.4 | GO:0007050 | cell cycle arrest(GO:0007050) |
0.0 | 0.4 | GO:0010592 | positive regulation of lamellipodium assembly(GO:0010592) |
0.0 | 0.1 | GO:0036506 | maintenance of unfolded protein(GO:0036506) protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) |
0.0 | 1.0 | GO:0030500 | regulation of bone mineralization(GO:0030500) |
0.0 | 0.1 | GO:0030035 | microspike assembly(GO:0030035) |
0.0 | 0.2 | GO:0046697 | decidualization(GO:0046697) |
0.0 | 0.4 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
0.0 | 0.3 | GO:0032967 | positive regulation of collagen biosynthetic process(GO:0032967) |
0.0 | 0.5 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
0.0 | 1.9 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.6 | 4.9 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
0.7 | 3.5 | GO:1990357 | terminal web(GO:1990357) |
0.7 | 4.0 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
0.3 | 4.7 | GO:0005922 | connexon complex(GO:0005922) |
0.3 | 10.9 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
0.3 | 10.3 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
0.2 | 3.1 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
0.2 | 3.7 | GO:0001741 | XY body(GO:0001741) |
0.2 | 0.5 | GO:0070765 | gamma-secretase complex(GO:0070765) |
0.1 | 0.9 | GO:0001674 | female germ cell nucleus(GO:0001674) |
0.1 | 0.6 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
0.1 | 2.5 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
0.1 | 9.3 | GO:0005581 | collagen trimer(GO:0005581) |
0.1 | 7.2 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
0.1 | 1.1 | GO:0030061 | mitochondrial crista(GO:0030061) |
0.1 | 11.2 | GO:0005884 | actin filament(GO:0005884) |
0.1 | 0.5 | GO:0031415 | NatA complex(GO:0031415) |
0.1 | 0.3 | GO:0097450 | astrocyte end-foot(GO:0097450) |
0.1 | 0.2 | GO:0070469 | respiratory chain(GO:0070469) |
0.1 | 0.5 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
0.1 | 0.4 | GO:0036195 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
0.0 | 3.6 | GO:0001669 | acrosomal vesicle(GO:0001669) |
0.0 | 2.7 | GO:0031985 | Golgi cisterna(GO:0031985) |
0.0 | 1.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
0.0 | 0.4 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
0.0 | 0.1 | GO:0031084 | BLOC-2 complex(GO:0031084) |
0.0 | 0.4 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
0.0 | 0.6 | GO:0030673 | axolemma(GO:0030673) |
0.0 | 0.1 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
0.0 | 0.1 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
0.0 | 1.7 | GO:0005814 | centriole(GO:0005814) |
0.0 | 2.1 | GO:0030018 | Z disc(GO:0030018) |
0.0 | 0.7 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
0.0 | 0.5 | GO:0035145 | exon-exon junction complex(GO:0035145) |
0.0 | 0.2 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.0 | 9.8 | GO:0001640 | adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) |
1.1 | 11.2 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
1.0 | 3.0 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
0.5 | 7.3 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
0.5 | 4.0 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
0.5 | 2.3 | GO:0071253 | connexin binding(GO:0071253) |
0.5 | 3.7 | GO:0051718 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718) |
0.5 | 2.7 | GO:0015375 | glycine:sodium symporter activity(GO:0015375) |
0.4 | 2.0 | GO:0038132 | neuregulin binding(GO:0038132) |
0.3 | 2.1 | GO:0070728 | leucine binding(GO:0070728) |
0.3 | 2.4 | GO:0070191 | methionine-R-sulfoxide reductase activity(GO:0070191) |
0.3 | 1.2 | GO:0004921 | interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970) |
0.3 | 1.1 | GO:0086038 | calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038) |
0.2 | 0.7 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
0.2 | 10.3 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.2 | 2.3 | GO:0005243 | gap junction channel activity(GO:0005243) |
0.2 | 6.9 | GO:0005112 | Notch binding(GO:0005112) |
0.2 | 1.1 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) |
0.2 | 0.6 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
0.2 | 0.5 | GO:0008502 | melatonin receptor activity(GO:0008502) |
0.1 | 0.6 | GO:0042806 | fucose binding(GO:0042806) |
0.1 | 5.0 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
0.1 | 2.1 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
0.1 | 0.4 | GO:0050436 | microfibril binding(GO:0050436) |
0.1 | 1.9 | GO:0008307 | structural constituent of muscle(GO:0008307) |
0.1 | 2.2 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.1 | 2.6 | GO:0008432 | JUN kinase binding(GO:0008432) |
0.1 | 1.1 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
0.1 | 1.1 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
0.1 | 3.2 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
0.1 | 1.1 | GO:0016208 | AMP binding(GO:0016208) |
0.0 | 0.1 | GO:0008515 | sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157) |
0.0 | 0.4 | GO:0046790 | virion binding(GO:0046790) |
0.0 | 0.5 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
0.0 | 0.2 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
0.0 | 3.0 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
0.0 | 0.7 | GO:0004385 | guanylate kinase activity(GO:0004385) |
0.0 | 0.4 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
0.0 | 1.1 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
0.0 | 1.1 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
0.0 | 4.0 | GO:0051015 | actin filament binding(GO:0051015) |
0.0 | 2.7 | GO:0017048 | Rho GTPase binding(GO:0017048) |
0.0 | 7.1 | GO:0008022 | protein C-terminus binding(GO:0008022) |
0.0 | 0.8 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
0.0 | 0.7 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
0.0 | 0.4 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
0.0 | 0.4 | GO:0035198 | miRNA binding(GO:0035198) |
0.0 | 1.4 | GO:0019210 | protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210) |
0.0 | 0.3 | GO:0016594 | glycine binding(GO:0016594) |
0.0 | 1.7 | GO:0030674 | protein binding, bridging(GO:0030674) |
0.0 | 2.6 | GO:0000287 | magnesium ion binding(GO:0000287) |
0.0 | 0.1 | GO:0005047 | signal recognition particle binding(GO:0005047) |