Motif ID: Tbx2

Z-value: 0.614


Transcription factors associated with Tbx2:

Gene SymbolEntrez IDGene Name
Tbx2 ENSMUSG00000000093.6 Tbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbx2mm10_v2_chr11_+_85832551_85832551-0.523.3e-06Click!


Activity profile for motif Tbx2.

activity profile for motif Tbx2


Sorted Z-values histogram for motif Tbx2

Sorted Z-values for motif Tbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 114 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_138847579 6.661 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr11_-_84068766 5.046 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr2_+_124089961 4.964 ENSMUST00000103241.1
 Sema6d
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr2_+_152081529 4.252 ENSMUST00000064061.3
 Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chr11_-_84068357 4.199 ENSMUST00000100705.4
 Dusp14
dual specificity phosphatase 14
chr10_+_26229707 3.825 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr6_+_115134899 3.521 ENSMUST00000009538.5
ENSMUST00000169345.1
 Syn2

synapsin II

chr1_-_52500679 3.344 ENSMUST00000069792.7
 Nab1
Ngfi-A binding protein 1
chr12_-_41485751 3.003 ENSMUST00000043884.4
 Lrrn3
leucine rich repeat protein 3, neuronal
chr4_+_116221633 2.924 ENSMUST00000030464.7
 Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr1_-_105356658 2.892 ENSMUST00000058688.5
ENSMUST00000172299.1
 Rnf152

ring finger protein 152

chr17_+_3397189 2.889 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr5_+_111733924 2.779 ENSMUST00000180627.1
 Gm26897
predicted gene, 26897
chr9_+_53850243 2.660 ENSMUST00000048485.5
 Sln
sarcolipin
chr2_+_52857844 2.614 ENSMUST00000090952.4
ENSMUST00000049483.6
ENSMUST00000050719.6
 Fmnl2


formin-like 2


chr4_+_116221689 2.551 ENSMUST00000106490.2
 Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr3_-_158562199 2.354 ENSMUST00000106044.1
 Lrrc7
leucine rich repeat containing 7
chr9_+_48495345 2.260 ENSMUST00000048824.7
 Gm5617
predicted gene 5617
chr7_-_137314394 2.217 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr3_+_32436376 2.147 ENSMUST00000108242.1
 Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.2 8.7 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
1.3 6.7 GO:0035262 gonad morphogenesis(GO:0035262)
0.2 5.0 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.1 4.3 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 3.5 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.7 3.4 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.1 3.3 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.2 3.1 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 3.0 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.9 2.7 GO:1902277 negative regulation of pancreatic amylase secretion(GO:1902277)
0.7 2.7 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.2 2.2 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.7 2.1 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.5 2.1 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.4 2.1 GO:0007386 compartment pattern specification(GO:0007386)
0.1 2.0 GO:0010107 potassium ion import(GO:0010107)
0.0 1.8 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.3 1.6 GO:0060467 negative regulation of fertilization(GO:0060467)
0.5 1.5 GO:0001928 regulation of exocyst assembly(GO:0001928)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 4.0 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 3.5 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 3.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 3.0 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 2.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 2.4 GO:0043194 axon initial segment(GO:0043194)
0.0 2.3 GO:0008021 synaptic vesicle(GO:0008021)
0.7 2.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 1.9 GO:0005770 late endosome(GO:0005770)
0.1 1.8 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 1.8 GO:0005814 centriole(GO:0005814)
0.0 1.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.2 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 1.1 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 1.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 1.0 GO:0031430 M band(GO:0031430)
0.0 1.0 GO:0030992 intraciliary transport particle B(GO:0030992)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
1.1 7.6 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 5.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.5 4.1 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 3.4 GO:0035064 methylated histone binding(GO:0035064)
0.0 3.4 GO:0030674 protein binding, bridging(GO:0030674)
0.0 3.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 3.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 2.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 2.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 2.6 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 2.2 GO:0017022 myosin binding(GO:0017022)
0.5 2.1 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.3 2.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.1 2.1 GO:0005112 Notch binding(GO:0005112)
0.4 2.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 1.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.5 GO:0030275 LRR domain binding(GO:0030275)
0.1 1.4 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 1.4 GO:0030898 actin-dependent ATPase activity(GO:0030898)