Motif ID: Tbx4
Z-value: 1.224
Transcription factors associated with Tbx4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Tbx4 | ENSMUSG00000000094.6 | Tbx4 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.2 | 15.5 | GO:0032474 | otolith morphogenesis(GO:0032474) |
| 4.5 | 13.6 | GO:0061537 | glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537) |
| 3.5 | 10.5 | GO:0001951 | intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896) |
| 2.9 | 11.6 | GO:0060032 | notochord regression(GO:0060032) |
| 2.8 | 28.1 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 2.7 | 8.0 | GO:0044333 | Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041) |
| 2.5 | 12.6 | GO:0030091 | protein repair(GO:0030091) |
| 2.2 | 8.8 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 2.0 | 17.8 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 1.9 | 5.8 | GO:2000852 | regulation of corticosterone secretion(GO:2000852) |
| 1.9 | 9.6 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 1.8 | 8.9 | GO:0035262 | gonad morphogenesis(GO:0035262) |
| 1.6 | 4.9 | GO:0045014 | detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594) |
| 1.5 | 19.3 | GO:0060159 | regulation of dopamine receptor signaling pathway(GO:0060159) |
| 1.3 | 10.7 | GO:0044027 | hypermethylation of CpG island(GO:0044027) |
| 1.2 | 13.0 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 1.1 | 9.6 | GO:0048752 | semicircular canal morphogenesis(GO:0048752) |
| 1.0 | 8.8 | GO:0071493 | cellular response to UV-B(GO:0071493) replicative senescence(GO:0090399) |
| 0.9 | 11.0 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
| 0.9 | 7.2 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
| 0.9 | 3.5 | GO:0007412 | axon target recognition(GO:0007412) |
| 0.8 | 2.3 | GO:0006546 | glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464) |
| 0.8 | 6.0 | GO:0048625 | myoblast fate commitment(GO:0048625) |
| 0.7 | 13.4 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
| 0.6 | 2.6 | GO:1902202 | regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) |
| 0.5 | 3.6 | GO:0006297 | nucleotide-excision repair, DNA gap filling(GO:0006297) |
| 0.5 | 4.5 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.4 | 10.3 | GO:0045672 | positive regulation of osteoclast differentiation(GO:0045672) |
| 0.4 | 13.4 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.4 | 1.6 | GO:1903587 | regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587) |
| 0.4 | 7.6 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.3 | 3.0 | GO:0071318 | cellular response to ATP(GO:0071318) |
| 0.3 | 8.2 | GO:0007340 | acrosome reaction(GO:0007340) |
| 0.3 | 3.1 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.3 | 0.9 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.3 | 3.0 | GO:1901409 | regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407) positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.3 | 2.1 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.2 | 3.9 | GO:0006851 | mitochondrial calcium ion transport(GO:0006851) |
| 0.2 | 5.2 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.2 | 2.8 | GO:0097067 | negative regulation of erythrocyte differentiation(GO:0045647) cellular response to thyroid hormone stimulus(GO:0097067) |
| 0.2 | 1.8 | GO:0015868 | purine ribonucleotide transport(GO:0015868) |
| 0.2 | 5.7 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
| 0.2 | 1.0 | GO:0035356 | cellular triglyceride homeostasis(GO:0035356) |
| 0.2 | 12.9 | GO:0008543 | fibroblast growth factor receptor signaling pathway(GO:0008543) |
| 0.2 | 0.8 | GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) |
| 0.2 | 1.3 | GO:0060059 | embryonic retina morphogenesis in camera-type eye(GO:0060059) |
| 0.1 | 0.5 | GO:0035521 | monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522) |
| 0.1 | 2.2 | GO:0006465 | signal peptide processing(GO:0006465) |
| 0.1 | 1.6 | GO:0007202 | activation of phospholipase C activity(GO:0007202) |
| 0.1 | 7.4 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.1 | 3.0 | GO:0035019 | somatic stem cell population maintenance(GO:0035019) |
| 0.1 | 1.3 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.0 | 8.7 | GO:0007519 | skeletal muscle tissue development(GO:0007519) |
| 0.0 | 2.3 | GO:0008347 | glial cell migration(GO:0008347) |
| 0.0 | 3.1 | GO:0043966 | histone H3 acetylation(GO:0043966) |
| 0.0 | 0.1 | GO:0019348 | dolichol metabolic process(GO:0019348) |
| 0.0 | 1.4 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
| 0.0 | 0.9 | GO:0071385 | cellular response to glucocorticoid stimulus(GO:0071385) |
| 0.0 | 1.2 | GO:0006493 | protein O-linked glycosylation(GO:0006493) |
| 0.0 | 0.1 | GO:0015871 | choline transport(GO:0015871) |
| 0.0 | 0.7 | GO:0030500 | regulation of bone mineralization(GO:0030500) |
| 0.0 | 1.9 | GO:0045667 | regulation of osteoblast differentiation(GO:0045667) |
| 0.0 | 1.2 | GO:2000177 | regulation of neural precursor cell proliferation(GO:2000177) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 8.8 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 2.1 | 10.5 | GO:1990357 | terminal web(GO:1990357) |
| 1.3 | 7.6 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.9 | 11.6 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.7 | 2.2 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.7 | 6.0 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.5 | 19.3 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.5 | 10.7 | GO:0001741 | XY body(GO:0001741) |
| 0.4 | 5.3 | GO:0005922 | connexon complex(GO:0005922) |
| 0.3 | 19.7 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.3 | 17.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.3 | 2.1 | GO:0031415 | NatA complex(GO:0031415) |
| 0.3 | 3.9 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.2 | 3.0 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.2 | 3.0 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.2 | 13.4 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.2 | 28.1 | GO:0005884 | actin filament(GO:0005884) |
| 0.2 | 0.7 | GO:0031084 | BLOC-2 complex(GO:0031084) |
| 0.2 | 3.1 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.2 | 4.5 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.1 | 1.3 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.1 | 3.0 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 9.3 | GO:0030018 | Z disc(GO:0030018) |
| 0.1 | 29.9 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 0.8 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 4.9 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.1 | 3.9 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 16.6 | GO:0098793 | presynapse(GO:0098793) |
| 0.0 | 1.4 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 4.0 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 3.4 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.0 | 1.3 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 1.2 | GO:0035097 | histone methyltransferase complex(GO:0035097) |
| 0.0 | 8.9 | GO:0009986 | cell surface(GO:0009986) |
| 0.0 | 0.5 | GO:0031519 | PcG protein complex(GO:0031519) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 12.9 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) |
| 2.8 | 28.1 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 2.3 | 13.6 | GO:0015375 | glycine:sodium symporter activity(GO:0015375) |
| 1.8 | 12.6 | GO:0070191 | methionine-R-sulfoxide reductase activity(GO:0070191) |
| 1.5 | 8.8 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) |
| 1.3 | 10.7 | GO:0051718 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718) |
| 1.0 | 3.9 | GO:0086038 | calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038) |
| 0.9 | 7.6 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.9 | 17.8 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.9 | 4.5 | GO:0001640 | adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) |
| 0.9 | 2.6 | GO:0005171 | hepatocyte growth factor receptor binding(GO:0005171) |
| 0.6 | 8.8 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.5 | 9.1 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.5 | 16.5 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.4 | 19.3 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.4 | 5.3 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.4 | 3.0 | GO:0046790 | virion binding(GO:0046790) |
| 0.4 | 8.0 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.4 | 19.1 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.3 | 9.6 | GO:0005112 | Notch binding(GO:0005112) |
| 0.3 | 12.4 | GO:0070888 | E-box binding(GO:0070888) |
| 0.3 | 6.0 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.2 | 0.8 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.2 | 1.6 | GO:0016004 | phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229) |
| 0.2 | 3.3 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.2 | 11.4 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.2 | 16.6 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.2 | 2.1 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.2 | 5.7 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 3.6 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.1 | 2.3 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 5.2 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.1 | 2.3 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.1 | 1.2 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.1 | 10.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 1.1 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.1 | 1.2 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.1 | 19.7 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.1 | 10.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 6.0 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.1 | 4.6 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.0 | 0.1 | GO:0003976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976) |
| 0.0 | 15.2 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.0 | 5.7 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 27.7 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.0 | 0.1 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
| 0.0 | 1.6 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.0 | 1.3 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
