Motif ID: Tbx5

Z-value: 0.625


Transcription factors associated with Tbx5:

Gene SymbolEntrez IDGene Name
Tbx5 ENSMUSG00000018263.8 Tbx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbx5mm10_v2_chr5_+_119834663_119834663-0.104.1e-01Click!


Activity profile for motif Tbx5.

activity profile for motif Tbx5


Sorted Z-values histogram for motif Tbx5

Sorted Z-values for motif Tbx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 4.701 ENSMUST00000060716.5
ENSMUST00000164660.1
Samd3

sterile alpha motif domain containing 3

chr1_-_138848576 4.547 ENSMUST00000112030.2
Lhx9
LIM homeobox protein 9
chr5_-_22344690 3.088 ENSMUST00000062372.7
ENSMUST00000161356.1
Reln

reelin

chr3_+_75557530 3.038 ENSMUST00000161776.1
ENSMUST00000029423.8
Serpini1

serine (or cysteine) peptidase inhibitor, clade I, member 1

chr2_-_54085542 2.760 ENSMUST00000100089.2
Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr1_-_75219245 2.737 ENSMUST00000079464.6
Tuba4a
tubulin, alpha 4A
chr5_+_98180866 2.305 ENSMUST00000112959.1
Prdm8
PR domain containing 8
chr1_-_105356658 2.115 ENSMUST00000058688.5
ENSMUST00000172299.1
Rnf152

ring finger protein 152

chr7_-_28302238 2.013 ENSMUST00000108315.3
Dll3
delta-like 3 (Drosophila)
chr11_-_84068766 1.921 ENSMUST00000018792.5
Dusp14
dual specificity phosphatase 14
chr14_+_122475397 1.883 ENSMUST00000075888.5
Zic2
zinc finger protein of the cerebellum 2
chr9_-_44320229 1.800 ENSMUST00000065080.8
C2cd2l
C2 calcium-dependent domain containing 2-like
chr11_+_98348404 1.783 ENSMUST00000078694.6
Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr4_+_128883549 1.583 ENSMUST00000035667.8
Trim62
tripartite motif-containing 62
chrX_-_147554050 1.530 ENSMUST00000112819.2
ENSMUST00000136789.1
Lrch2

leucine-rich repeats and calponin homology (CH) domain containing 2

chr6_+_115134899 1.515 ENSMUST00000009538.5
ENSMUST00000169345.1
Syn2

synapsin II

chr4_-_41517326 1.499 ENSMUST00000030152.6
ENSMUST00000095126.4
1110017D15Rik

RIKEN cDNA 1110017D15 gene

chr7_-_140082246 1.470 ENSMUST00000166758.2
Caly
calcyon neuron-specific vesicular protein
chr19_+_4003334 1.395 ENSMUST00000025806.3
Doc2g
double C2, gamma
chr11_-_116654245 1.375 ENSMUST00000021166.5
Cygb
cytoglobin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 136 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 4.5 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 3.0 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.2 2.4 GO:0097067 negative regulation of erythrocyte differentiation(GO:0045647) cellular response to thyroid hormone stimulus(GO:0097067)
0.1 2.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2 2.3 GO:0021540 corpus callosum morphogenesis(GO:0021540)
0.6 2.2 GO:0097477 lateral motor column neuron migration(GO:0097477)
0.2 2.1 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.4 2.0 GO:0007386 compartment pattern specification(GO:0007386)
0.5 1.9 GO:1900145 regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145) regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900175) positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.1 1.9 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.6 1.8 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.6 1.8 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.0 1.8 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.0 1.8 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.1 1.7 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.0 1.6 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.3 1.5 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.1 1.5 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 1.5 GO:0048240 sperm capacitation(GO:0048240)
0.1 1.5 GO:0048268 clathrin coat assembly(GO:0048268)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 2.2 GO:0030496 midbody(GO:0030496)
0.1 1.9 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 1.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.5 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 1.5 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.5 GO:0035097 histone methyltransferase complex(GO:0035097)
0.3 1.4 GO:0002177 manchette(GO:0002177)
0.0 1.3 GO:0043204 perikaryon(GO:0043204)
0.2 1.2 GO:0042629 mast cell granule(GO:0042629)
0.1 1.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 1.0 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 1.0 GO:0005814 centriole(GO:0005814)
0.1 0.9 GO:0016589 NURF complex(GO:0016589)
0.1 0.9 GO:0031045 dense core granule(GO:0031045)
0.0 0.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.3 0.8 GO:0035061 interchromatin granule(GO:0035061)
0.1 0.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.8 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.7 GO:0044530 supraspliceosomal complex(GO:0044530)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.2 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.5 3.1 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0 2.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 2.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.3 2.5 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.1 2.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.4 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 2.2 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 2.0 GO:0005112 Notch binding(GO:0005112)
0.1 1.9 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.6 1.8 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.2 1.8 GO:0043559 insulin binding(GO:0043559)
0.1 1.8 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 1.6 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.3 1.5 GO:0050062 long-chain-fatty-acyl-CoA reductase activity(GO:0050062) fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.2 1.5 GO:0032051 clathrin light chain binding(GO:0032051)
0.1 1.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 1.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.5 GO:0048306 calcium-dependent protein binding(GO:0048306)