Motif ID: Tcf21_Msc

Z-value: 1.207

Transcription factors associated with Tcf21_Msc:

Gene SymbolEntrez IDGene Name
Msc ENSMUSG00000025930.5 Msc
Tcf21 ENSMUSG00000045680.7 Tcf21



Activity profile for motif Tcf21_Msc.

activity profile for motif Tcf21_Msc


Sorted Z-values histogram for motif Tcf21_Msc

Sorted Z-values for motif Tcf21_Msc



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf21_Msc

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_122611238 17.625 ENSMUST00000028624.8
 Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chrX_-_106485214 16.532 ENSMUST00000039447.7
 Fndc3c1
fibronectin type III domain containing 3C1
chr3_+_90537242 14.209 ENSMUST00000098911.3
 S100a16
S100 calcium binding protein A16
chr8_-_122432924 13.064 ENSMUST00000017604.8
 Cyba
cytochrome b-245, alpha polypeptide
chr8_+_94172618 12.851 ENSMUST00000034214.6
 Mt2
metallothionein 2
chr13_-_100786402 12.728 ENSMUST00000174038.1
ENSMUST00000091295.7
ENSMUST00000072119.8
 Ccnb1


cyclin B1


chrX_-_106485367 12.670 ENSMUST00000140707.1
 Fndc3c1
fibronectin type III domain containing 3C1
chr14_-_20181773 12.644 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr2_-_105399286 12.499 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr15_+_78926720 11.611 ENSMUST00000089377.5
 Lgals1
lectin, galactose binding, soluble 1
chr3_+_90537306 11.504 ENSMUST00000107335.1
 S100a16
S100 calcium binding protein A16
chrX_+_100730178 11.311 ENSMUST00000113744.1
 Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr16_+_91269759 9.631 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr13_-_71963713 9.471 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr12_-_91779129 9.358 ENSMUST00000170077.1
 Ston2
stonin 2
chr3_+_14863495 9.116 ENSMUST00000029076.4
 Car3
carbonic anhydrase 3
chr18_+_50051702 8.792 ENSMUST00000134348.1
ENSMUST00000153873.2
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr7_+_45216671 8.615 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr11_-_55419898 8.578 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr18_+_4994600 8.250 ENSMUST00000140448.1
 Svil
supervillin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 231 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 21.3 GO:0051592 response to calcium ion(GO:0051592)
5.9 17.6 GO:0006601 creatine biosynthetic process(GO:0006601)
1.8 15.8 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
4.4 13.1 GO:0033860 regulation of NAD(P)H oxidase activity(GO:0033860)
1.8 12.9 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
3.2 12.7 GO:0043987 histone H3-S10 phosphorylation(GO:0043987)
2.3 11.6 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.3 11.4 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
1.0 10.6 GO:0042572 retinol metabolic process(GO:0042572)
1.1 10.5 GO:0090527 actin filament reorganization(GO:0090527)
0.1 10.4 GO:0048709 oligodendrocyte differentiation(GO:0048709)
0.3 9.4 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.6 9.0 GO:0090205 positive regulation of cholesterol biosynthetic process(GO:0045542) positive regulation of cholesterol metabolic process(GO:0090205)
0.3 8.9 GO:0006730 one-carbon metabolic process(GO:0006730)
0.2 8.8 GO:0032611 interleukin-1 beta production(GO:0032611)
0.5 8.6 GO:0048368 lateral mesoderm development(GO:0048368)
1.4 8.5 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.7 8.2 GO:0014842 regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.7 7.0 GO:0030322 stabilization of membrane potential(GO:0030322)
0.7 6.9 GO:0048199 vesicle targeting, to, from or within Golgi(GO:0048199)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 27.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 18.3 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 17.7 GO:0005730 nucleolus(GO:0005730)
0.2 16.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 15.7 GO:0005667 transcription factor complex(GO:0005667)
3.3 13.1 GO:0043020 NADPH oxidase complex(GO:0043020)
3.2 12.7 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 10.1 GO:0005615 extracellular space(GO:0005615)
0.1 9.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 9.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
2.1 8.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 8.5 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.1 8.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 7.2 GO:0016459 myosin complex(GO:0016459)
0.5 6.9 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 6.8 GO:0031901 early endosome membrane(GO:0031901)
0.1 6.8 GO:0032993 protein-DNA complex(GO:0032993)
0.2 6.3 GO:0043034 costamere(GO:0043034)
0.2 6.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.9 6.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 151 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 26.1 GO:0005509 calcium ion binding(GO:0005509)
0.8 22.3 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
2.9 14.6 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 14.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 13.2 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
3.3 13.1 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
1.1 13.0 GO:0004089 carbonate dehydratase activity(GO:0004089)
2.5 12.7 GO:0005113 patched binding(GO:0005113)
3.9 11.6 GO:0005534 galactose binding(GO:0005534)
1.1 11.3 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.2 11.0 GO:0050840 extracellular matrix binding(GO:0050840)
1.5 10.6 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.4 10.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.2 9.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.8 8.0 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.3 7.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.4 7.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 7.4 GO:0042169 SH2 domain binding(GO:0042169)
0.3 7.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.6 7.0 GO:0004176 ATP-dependent peptidase activity(GO:0004176)