Motif ID: Tcf3

Z-value: 0.733


Transcription factors associated with Tcf3:

Gene SymbolEntrez IDGene Name
Tcf3 ENSMUSG00000020167.8 Tcf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf3mm10_v2_chr10_-_80421847_804218760.599.9e-08Click!


Activity profile for motif Tcf3.

activity profile for motif Tcf3


Sorted Z-values histogram for motif Tcf3

Sorted Z-values for motif Tcf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_109459843 11.038 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr14_+_27039001 8.604 ENSMUST00000035336.3
 Il17rd
interleukin 17 receptor D
chr4_-_43523388 8.597 ENSMUST00000107913.3
ENSMUST00000030184.5
 Tpm2

tropomyosin 2, beta

chr6_-_72235559 8.045 ENSMUST00000042646.7
 Atoh8
atonal homolog 8 (Drosophila)
chr6_+_29694204 7.491 ENSMUST00000046750.7
ENSMUST00000115250.3
 Tspan33

tetraspanin 33

chr15_+_34238026 7.453 ENSMUST00000022867.3
 Laptm4b
lysosomal-associated protein transmembrane 4B
chr14_-_20181773 7.411 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr2_-_122611238 7.149 ENSMUST00000028624.8
 Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr4_-_43523746 7.053 ENSMUST00000150592.1
 Tpm2
tropomyosin 2, beta
chr4_-_43523595 6.747 ENSMUST00000107914.3
 Tpm2
tropomyosin 2, beta
chr19_-_45560508 6.702 ENSMUST00000026239.6
 Poll
polymerase (DNA directed), lambda
chr7_+_19094594 6.193 ENSMUST00000049454.5
 Six5
sine oculis-related homeobox 5
chr13_-_60177357 6.144 ENSMUST00000065086.4
 Gas1
growth arrest specific 1
chr7_-_28302238 5.728 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr8_+_105518736 5.676 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr2_+_131186942 5.569 ENSMUST00000028804.8
ENSMUST00000079857.8
 Cdc25b

cell division cycle 25B

chr17_-_35703971 5.478 ENSMUST00000148065.1
 Ddr1
discoidin domain receptor family, member 1
chr7_+_45216671 5.450 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr15_-_98004695 5.409 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr17_+_75178797 5.388 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 232 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 13.0 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.6 11.6 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
1.0 11.4 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.3 10.3 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
2.2 8.7 GO:0060032 notochord regression(GO:0060032)
0.3 8.5 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.9 8.0 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
1.9 7.7 GO:0046836 glycolipid transport(GO:0046836)
0.7 7.7 GO:0042473 outer ear morphogenesis(GO:0042473)
0.1 7.7 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.8 7.6 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
2.4 7.1 GO:0006601 creatine biosynthetic process(GO:0006601)
1.4 7.1 GO:0014719 skeletal muscle satellite cell activation(GO:0014719)
0.4 6.8 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.4 6.8 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
1.1 6.7 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.5 6.2 GO:0014842 skeletal muscle satellite cell proliferation(GO:0014841) regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.5 6.0 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
1.1 5.7 GO:0007386 compartment pattern specification(GO:0007386)
0.6 5.7 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 22.4 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.9 11.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
3.4 10.2 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.1 9.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.7 8.7 GO:0097542 ciliary tip(GO:0097542)
0.1 8.0 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1 7.7 GO:0016459 myosin complex(GO:0016459)
1.1 7.5 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 7.5 GO:0000922 spindle pole(GO:0000922)
0.3 7.1 GO:0001891 phagocytic cup(GO:0001891)
0.0 7.0 GO:0016323 basolateral plasma membrane(GO:0016323)
1.4 6.8 GO:0097149 centralspindlin complex(GO:0097149)
0.2 6.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 5.7 GO:0005923 bicellular tight junction(GO:0005923)
1.7 5.1 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.8 4.7 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 4.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 4.6 GO:0031012 extracellular matrix(GO:0031012)
0.1 4.5 GO:0072562 blood microparticle(GO:0072562)
0.9 4.4 GO:0033093 Weibel-Palade body(GO:0033093)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 153 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.5 13.5 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
1.3 11.7 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.3 11.5 GO:0070888 E-box binding(GO:0070888)
0.7 10.7 GO:0048407 platelet-derived growth factor binding(GO:0048407)
2.6 10.3 GO:0050436 microfibril binding(GO:0050436)
0.1 10.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 9.5 GO:0005525 GTP binding(GO:0005525)
0.0 9.4 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
2.9 8.6 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.3 8.5 GO:0005112 Notch binding(GO:0005112)
0.5 8.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 8.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 7.8 GO:0003774 motor activity(GO:0003774)
2.6 7.7 GO:0017089 glycolipid transporter activity(GO:0017089)
0.1 7.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 7.4 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.3 7.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 6.9 GO:0005096 GTPase activator activity(GO:0005096)
0.3 6.5 GO:0071855 neuropeptide receptor binding(GO:0071855)