Motif ID: Tcf4_Mesp1

Z-value: 2.842

Transcription factors associated with Tcf4_Mesp1:

Gene SymbolEntrez IDGene Name
Mesp1 ENSMUSG00000030544.5 Mesp1
Tcf4 ENSMUSG00000053477.9 Tcf4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf4mm10_v2_chr18_+_69593361_695934500.362.2e-03Click!


Activity profile for motif Tcf4_Mesp1.

activity profile for motif Tcf4_Mesp1


Sorted Z-values histogram for motif Tcf4_Mesp1

Sorted Z-values for motif Tcf4_Mesp1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf4_Mesp1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66831625 66.242 ENSMUST00000164163.1
 Sla
src-like adaptor
chr13_-_57907587 61.885 ENSMUST00000172326.1
 Spock1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
chr13_+_83504032 46.015 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr3_+_75557530 44.798 ENSMUST00000161776.1
ENSMUST00000029423.8
 Serpini1

serine (or cysteine) peptidase inhibitor, clade I, member 1

chr5_+_37028329 43.686 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr11_-_67922136 38.760 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr10_+_123264076 31.451 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr5_-_139130159 31.406 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr7_+_16310412 30.714 ENSMUST00000136781.1
 Bbc3
BCL2 binding component 3
chr12_+_82616885 29.527 ENSMUST00000161801.1
 Rgs6
regulator of G-protein signaling 6
chr16_-_97170707 29.303 ENSMUST00000056102.7
 Dscam
Down syndrome cell adhesion molecule
chr7_+_44384803 28.479 ENSMUST00000120262.1
 Syt3
synaptotagmin III
chrX_-_73659724 28.031 ENSMUST00000114473.1
ENSMUST00000002087.7
 Pnck

pregnancy upregulated non-ubiquitously expressed CaM kinase

chr12_+_102948843 27.863 ENSMUST00000101099.5
 Unc79
unc-79 homolog (C. elegans)
chr7_-_4546567 27.260 ENSMUST00000065957.5
 Syt5
synaptotagmin V
chr18_-_42899294 27.041 ENSMUST00000117687.1
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr18_-_42899470 26.999 ENSMUST00000120632.1
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr5_+_117413977 26.985 ENSMUST00000180430.1
 Ksr2
kinase suppressor of ras 2
chr7_+_123982799 26.674 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr9_-_29411736 25.860 ENSMUST00000115236.1
 Ntm
neurotrimin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 575 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.7 84.5 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
7.7 54.0 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
1.0 51.1 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
12.5 50.2 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
1.3 50.0 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
1.2 47.4 GO:0008333 endosome to lysosome transport(GO:0008333)
15.3 46.0 GO:2000111 cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
2.0 44.0 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.5 43.8 GO:1903749 positive regulation of establishment of protein localization to mitochondrion(GO:1903749)
2.0 42.7 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
4.2 42.4 GO:0048149 behavioral response to ethanol(GO:0048149)
2.8 42.0 GO:0006750 glutathione biosynthetic process(GO:0006750)
1.0 41.2 GO:0034605 cellular response to heat(GO:0034605)
0.4 37.6 GO:0016579 protein deubiquitination(GO:0016579)
0.3 33.0 GO:0050890 cognition(GO:0050890)
2.3 32.8 GO:0060081 membrane hyperpolarization(GO:0060081)
4.6 32.4 GO:0061502 early endosome to recycling endosome transport(GO:0061502)
2.9 31.9 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
2.9 31.4 GO:0032482 Rab protein signal transduction(GO:0032482)
5.2 31.3 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 212 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 150.3 GO:0060076 excitatory synapse(GO:0060076)
0.8 104.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.8 96.5 GO:0055037 recycling endosome(GO:0055037)
1.0 94.8 GO:0043195 terminal bouton(GO:0043195)
2.1 90.0 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.6 84.9 GO:0097060 synaptic membrane(GO:0097060)
3.7 70.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
2.0 57.6 GO:0033268 node of Ranvier(GO:0033268)
0.4 55.3 GO:0019898 extrinsic component of membrane(GO:0019898)
0.1 54.7 GO:0031410 cytoplasmic vesicle(GO:0031410)
0.0 47.9 GO:0016021 integral component of membrane(GO:0016021)
1.0 44.6 GO:0031901 early endosome membrane(GO:0031901)
1.3 42.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
3.7 37.0 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.7 34.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
2.6 34.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.4 33.5 GO:0070382 exocytic vesicle(GO:0070382)
0.8 29.2 GO:0042734 presynaptic membrane(GO:0042734)
9.5 28.5 GO:0043512 inhibin A complex(GO:0043512)
2.7 27.4 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 369 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 97.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 75.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.3 71.3 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
5.0 70.7 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
3.6 65.4 GO:0050811 GABA receptor binding(GO:0050811)
3.0 62.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
1.1 55.5 GO:0045499 chemorepellent activity(GO:0045499)
1.3 54.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.4 52.3 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
1.5 50.2 GO:0030552 cAMP binding(GO:0030552)
3.8 49.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.5 48.1 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
4.1 45.2 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
2.3 44.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
4.0 43.5 GO:0003680 AT DNA binding(GO:0003680)
2.9 40.9 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
5.6 39.5 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.7 38.7 GO:0030507 spectrin binding(GO:0030507)
1.3 36.1 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
0.6 34.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)