Motif ID: Tcf7_Tcf7l2

Z-value: 1.154

Transcription factors associated with Tcf7_Tcf7l2:

Gene SymbolEntrez IDGene Name
Tcf7 ENSMUSG00000000782.9 Tcf7
Tcf7l2 ENSMUSG00000024985.12 Tcf7l2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf7l2mm10_v2_chr19_+_55742242_557424680.501.0e-05Click!
Tcf7mm10_v2_chr11_-_52282564_52282579-0.133.0e-01Click!


Activity profile for motif Tcf7_Tcf7l2.

activity profile for motif Tcf7_Tcf7l2


Sorted Z-values histogram for motif Tcf7_Tcf7l2

Sorted Z-values for motif Tcf7_Tcf7l2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf7_Tcf7l2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_102296256 8.514 ENSMUST00000064924.4
 Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr15_+_85859689 8.418 ENSMUST00000170629.1
 Gtse1
G two S phase expressed protein 1
chr2_+_102706356 8.135 ENSMUST00000123759.1
ENSMUST00000111212.1
ENSMUST00000005220.4
 Slc1a2


solute carrier family 1 (glial high affinity glutamate transporter), member 2


chr4_-_43499608 6.945 ENSMUST00000136005.1
ENSMUST00000054538.6
 Arhgef39

Rho guanine nucleotide exchange factor (GEF) 39

chr2_+_20737306 6.265 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr7_+_67655414 6.243 ENSMUST00000107470.1
 Ttc23
tetratricopeptide repeat domain 23
chr2_+_152081529 6.205 ENSMUST00000064061.3
 Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chr17_-_47016956 5.845 ENSMUST00000165525.1
 Gm16494
predicted gene 16494
chr3_+_76074270 5.742 ENSMUST00000038364.8
 Fstl5
follistatin-like 5
chr7_+_45216671 5.649 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr10_-_92165159 5.533 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr18_-_62756275 5.297 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr14_+_63436394 5.286 ENSMUST00000121288.1
 Fam167a
family with sequence similarity 167, member A
chr14_-_52020698 5.221 ENSMUST00000067549.7
 Zfp219
zinc finger protein 219
chr11_-_87108656 4.978 ENSMUST00000051395.8
 Prr11
proline rich 11
chr10_+_127725392 4.940 ENSMUST00000026466.3
 Tac2
tachykinin 2
chr7_+_27499315 4.700 ENSMUST00000098644.2
ENSMUST00000108355.1
 Prx

periaxin

chr1_+_157458554 4.406 ENSMUST00000046743.4
ENSMUST00000119891.1
 BC026585

cDNA sequence BC026585

chr2_+_153031852 4.402 ENSMUST00000037235.6
 Xkr7
X Kell blood group precursor related family member 7 homolog
chr5_-_44102032 4.259 ENSMUST00000171543.1
 Prom1
prominin 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 153 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 12.6 GO:0000212 meiotic spindle organization(GO:0000212)
1.4 8.1 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
1.5 6.0 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.1 5.8 GO:2001222 regulation of neuron migration(GO:2001222)
0.3 5.6 GO:0048368 notochord development(GO:0030903) lateral mesoderm development(GO:0048368)
1.3 5.2 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.3 5.2 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.3 5.2 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.2 5.2 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 5.0 GO:0001947 heart looping(GO:0001947)
0.8 4.9 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 4.9 GO:0006275 regulation of DNA replication(GO:0006275)
1.6 4.7 GO:0030421 defecation(GO:0030421)
0.0 4.7 GO:0048706 embryonic skeletal system development(GO:0048706)
1.4 4.3 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
0.3 4.0 GO:0042711 maternal behavior(GO:0042711)
0.3 4.0 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.4 3.9 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.2 3.7 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
1.2 3.6 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.4 GO:0005667 transcription factor complex(GO:0005667)
0.1 9.3 GO:0072686 mitotic spindle(GO:0072686)
0.2 8.1 GO:0030673 axolemma(GO:0030673)
0.1 7.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 5.7 GO:0072562 blood microparticle(GO:0072562)
0.0 5.7 GO:0005815 microtubule organizing center(GO:0005815)
0.1 5.3 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.9 4.6 GO:0036449 microtubule minus-end(GO:0036449)
0.2 4.6 GO:0010369 chromocenter(GO:0010369)
0.1 4.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
1.4 4.3 GO:0071914 prominosome(GO:0071914)
0.1 4.3 GO:0000922 spindle pole(GO:0000922)
0.2 4.2 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 4.2 GO:0005720 nuclear heterochromatin(GO:0005720)
0.3 3.6 GO:0030056 hemidesmosome(GO:0030056)
0.9 3.5 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.3 3.5 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 3.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 2.9 GO:0030478 actin cap(GO:0030478)
0.1 2.8 GO:0030131 clathrin adaptor complex(GO:0030131)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 16.1 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.2 8.7 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
0.1 8.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 8.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
2.0 8.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.3 6.0 GO:0070411 I-SMAD binding(GO:0070411)
0.1 5.6 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 5.3 GO:0070491 repressing transcription factor binding(GO:0070491)
0.2 5.2 GO:0008327 methyl-CpG binding(GO:0008327)
0.2 4.8 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 4.5 GO:0008201 heparin binding(GO:0008201)
0.0 4.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 4.2 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.1 3.9 GO:0050699 WW domain binding(GO:0050699)
0.9 3.6 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.6 3.6 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.2 3.6 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.1 3.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.4 3.5 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 3.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)