Motif ID: Tcf7l1

Z-value: 0.876


Transcription factors associated with Tcf7l1:

Gene SymbolEntrez IDGene Name
Tcf7l1 ENSMUSG00000055799.7 Tcf7l1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf7l1mm10_v2_chr6_-_72788952_727890610.423.2e-04Click!


Activity profile for motif Tcf7l1.

activity profile for motif Tcf7l1


Sorted Z-values histogram for motif Tcf7l1

Sorted Z-values for motif Tcf7l1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf7l1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_180889660 9.568 ENSMUST00000137629.1
 Gm14342
predicted gene 14342
chr17_-_70851189 7.852 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr14_+_27039001 7.140 ENSMUST00000035336.3
 Il17rd
interleukin 17 receptor D
chr3_+_131110350 7.018 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1


chr11_+_108920800 6.815 ENSMUST00000140821.1
 Axin2
axin2
chr7_-_49636847 6.106 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr1_-_183147461 5.693 ENSMUST00000171366.1
 Disp1
dispatched homolog 1 (Drosophila)
chr14_-_98169542 5.622 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr7_+_45216671 5.413 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr7_-_144939823 4.677 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr6_-_148944750 4.642 ENSMUST00000111562.1
ENSMUST00000081956.5
 Fam60a

family with sequence similarity 60, member A

chr11_+_108921648 4.627 ENSMUST00000144511.1
 Axin2
axin2
chr2_+_173022360 4.383 ENSMUST00000173997.1
 Rbm38
RNA binding motif protein 38
chrX_+_6415736 4.289 ENSMUST00000143641.3
 Shroom4
shroom family member 4
chr2_-_69586021 4.127 ENSMUST00000100051.2
ENSMUST00000092551.4
ENSMUST00000080953.5
 Lrp2


low density lipoprotein receptor-related protein 2


chr15_+_34238026 4.044 ENSMUST00000022867.3
 Laptm4b
lysosomal-associated protein transmembrane 4B
chrX_-_48034842 4.030 ENSMUST00000039026.7
 Apln
apelin
chr10_+_79988584 4.027 ENSMUST00000004784.4
ENSMUST00000105374.1
 Cnn2

calponin 2

chr18_+_82914632 4.026 ENSMUST00000071233.6
 Zfp516
zinc finger protein 516
chr17_-_89910449 4.022 ENSMUST00000086423.4
 Gm10184
predicted pseudogene 10184

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 123 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 13.3 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.5 8.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.7 8.0 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.5 7.7 GO:0048617 embryonic foregut morphogenesis(GO:0048617)
2.3 7.0 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.4 6.1 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.5 5.7 GO:0060539 diaphragm development(GO:0060539)
1.9 5.6 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.4 5.4 GO:0048368 lateral mesoderm development(GO:0048368)
0.7 4.7 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.1 4.2 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 4.2 GO:0007601 visual perception(GO:0007601)
0.4 4.1 GO:0045056 transcytosis(GO:0045056)
0.6 4.0 GO:0051461 positive regulation of heat generation(GO:0031652) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.3 4.0 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.1 4.0 GO:0009409 response to cold(GO:0009409)
0.5 3.8 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.5 3.6 GO:0061436 establishment of skin barrier(GO:0061436)
1.2 3.5 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826)
0.0 3.4 GO:0006261 DNA-dependent DNA replication(GO:0006261)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 29.3 GO:0005667 transcription factor complex(GO:0005667)
0.4 9.7 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.8 8.8 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 6.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.3 4.6 GO:0071564 npBAF complex(GO:0071564)
0.2 4.6 GO:0016580 Sin3 complex(GO:0016580)
0.1 4.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 4.3 GO:0016460 myosin II complex(GO:0016460)
0.4 4.2 GO:0001739 sex chromatin(GO:0001739)
0.1 4.1 GO:0031526 brush border membrane(GO:0031526)
0.2 3.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.7 3.4 GO:0008623 CHRAC(GO:0008623)
0.8 3.3 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.6 3.3 GO:0044294 dendritic growth cone(GO:0044294)
0.1 3.2 GO:0001772 immunological synapse(GO:0001772)
1.0 3.1 GO:0033193 Lsd1/2 complex(GO:0033193)
0.0 2.8 GO:0000922 spindle pole(GO:0000922)
0.2 2.5 GO:0036038 MKS complex(GO:0036038)
0.0 2.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.4 2.3 GO:0005726 perichromatin fibrils(GO:0005726)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 13.3 GO:0070411 I-SMAD binding(GO:0070411)
0.0 11.8 GO:0003682 chromatin binding(GO:0003682)
0.1 8.8 GO:0001047 core promoter binding(GO:0001047)
0.1 8.0 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.5 7.9 GO:0070410 co-SMAD binding(GO:0070410)
0.4 7.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
2.4 7.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
1.2 7.0 GO:0030284 estrogen receptor activity(GO:0030284)
0.5 6.3 GO:0015197 peptide transporter activity(GO:0015197)
0.1 6.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.9 5.6 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.2 5.5 GO:0070064 proline-rich region binding(GO:0070064)
0.1 5.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 4.8 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.2 4.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 4.6 GO:0051015 actin filament binding(GO:0051015)
1.4 4.2 GO:0005118 sevenless binding(GO:0005118)
0.8 4.1 GO:0030492 hemoglobin binding(GO:0030492)
0.1 4.1 GO:0033613 activating transcription factor binding(GO:0033613)
0.4 3.9 GO:0034711 inhibin binding(GO:0034711)