Motif ID: Tfap2c

Z-value: 0.807


Transcription factors associated with Tfap2c:

Gene SymbolEntrez IDGene Name
Tfap2c ENSMUSG00000028640.5 Tfap2c

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2cmm10_v2_chr2_+_172550761_172550782-0.665.2e-10Click!


Activity profile for motif Tfap2c.

activity profile for motif Tfap2c


Sorted Z-values histogram for motif Tfap2c

Sorted Z-values for motif Tfap2c



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2c

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_70493156 6.658 ENSMUST00000008032.7
 Crlf1
cytokine receptor-like factor 1
chr14_+_119138415 5.992 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr18_-_61911783 4.475 ENSMUST00000049378.8
ENSMUST00000166783.1
 Ablim3

actin binding LIM protein family, member 3

chr6_+_4505493 4.346 ENSMUST00000031668.8
 Col1a2
collagen, type I, alpha 2
chr4_+_152338887 4.320 ENSMUST00000005175.4
 Chd5
chromodomain helicase DNA binding protein 5
chr9_+_89909775 4.027 ENSMUST00000034912.4
ENSMUST00000034909.4
 Rasgrf1

RAS protein-specific guanine nucleotide-releasing factor 1

chr11_+_67455339 4.010 ENSMUST00000108681.1
 Gas7
growth arrest specific 7
chr4_+_152338619 3.813 ENSMUST00000030775.5
ENSMUST00000164662.1
 Chd5

chromodomain helicase DNA binding protein 5

chr9_-_29412204 3.725 ENSMUST00000115237.1
 Ntm
neurotrimin
chr6_+_38663061 3.543 ENSMUST00000114874.3
 Clec2l
C-type lectin domain family 2, member L
chr2_+_76406529 3.455 ENSMUST00000111929.1
ENSMUST00000077972.4
ENSMUST00000111930.2
 Osbpl6


oxysterol binding protein-like 6


chr9_-_29411736 3.389 ENSMUST00000115236.1
 Ntm
neurotrimin
chr5_-_131307848 3.286 ENSMUST00000086023.5
 Wbscr17
Williams-Beuren syndrome chromosome region 17 homolog (human)
chr7_-_31126945 3.096 ENSMUST00000098548.4
 Scn1b
sodium channel, voltage-gated, type I, beta
chr9_+_58823512 3.055 ENSMUST00000034889.8
 Hcn4
hyperpolarization-activated, cyclic nucleotide-gated K+ 4
chr1_-_75264195 3.049 ENSMUST00000027404.5
 Ptprn
protein tyrosine phosphatase, receptor type, N
chr10_+_13966268 3.031 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr7_-_4789541 2.956 ENSMUST00000168578.1
 Tmem238
transmembrane protein 238
chr4_+_124657646 2.802 ENSMUST00000053491.7
 Pou3f1
POU domain, class 3, transcription factor 1
chr11_-_120047070 2.755 ENSMUST00000064307.3
 Aatk
apoptosis-associated tyrosine kinase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 8.1 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.6 7.7 GO:0043589 skin morphogenesis(GO:0043589)
1.1 6.7 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
1.0 6.0 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 4.5 GO:0030032 lamellipodium assembly(GO:0030032)
0.2 4.3 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
1.0 4.1 GO:1904177 regulation of adipose tissue development(GO:1904177)
0.0 3.8 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.7 3.7 GO:0051012 microtubule sliding(GO:0051012) negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.0 3.7 GO:0030041 actin filament polymerization(GO:0030041)
0.1 3.3 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
1.0 3.1 GO:0086017 Purkinje myocyte action potential(GO:0086017)
0.6 3.1 GO:0070305 response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321)
0.2 3.0 GO:0001553 luteinization(GO:0001553)
0.1 2.9 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.9 2.8 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
0.3 2.8 GO:0032482 Rab protein signal transduction(GO:0032482)
0.7 2.7 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812) lateral motor column neuron migration(GO:0097477)
0.3 2.7 GO:1903423 positive regulation of synaptic vesicle recycling(GO:1903423)
0.2 2.7 GO:0060088 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910) auditory receptor cell stereocilium organization(GO:0060088)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.4 GO:0031225 anchored component of membrane(GO:0031225)
0.3 8.1 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
2.3 7.0 GO:0005584 collagen type I trimer(GO:0005584)
2.2 6.7 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 5.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 4.9 GO:0043679 axon terminus(GO:0043679)
0.0 4.8 GO:0005884 actin filament(GO:0005884)
0.6 4.1 GO:0005638 lamin filament(GO:0005638)
0.2 4.0 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 3.7 GO:0072686 mitotic spindle(GO:0072686)
0.1 3.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 3.1 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 3.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 2.8 GO:0044295 axonal growth cone(GO:0044295)
0.5 2.7 GO:0032426 stereocilium tip(GO:0032426)
0.3 2.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2 2.7 GO:0043196 varicosity(GO:0043196)
0.0 2.7 GO:0005903 brush border(GO:0005903)
0.0 2.7 GO:0000139 Golgi membrane(GO:0000139)
0.5 2.5 GO:0030485 smooth muscle contractile fiber(GO:0030485)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.6 GO:0003779 actin binding(GO:0003779)
0.1 8.1 GO:0008026 ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.5 7.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
1.0 6.7 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.2 6.0 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.0 4.3 GO:0005096 GTPase activator activity(GO:0005096)
0.2 4.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 4.1 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 4.0 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.9 3.7 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 3.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 3.4 GO:0000287 magnesium ion binding(GO:0000287)
0.2 3.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.6 3.1 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.4 3.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.3 3.0 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 3.0 GO:0030507 spectrin binding(GO:0030507)
0.3 2.8 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.2 2.7 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 2.7 GO:0042169 SH2 domain binding(GO:0042169)