Motif ID: Tfcp2

Z-value: 1.746


Transcription factors associated with Tfcp2:

Gene SymbolEntrez IDGene Name
Tfcp2 ENSMUSG00000009733.8 Tfcp2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfcp2mm10_v2_chr15_-_100551959_1005520100.301.3e-02Click!


Activity profile for motif Tfcp2.

activity profile for motif Tfcp2


Sorted Z-values histogram for motif Tfcp2

Sorted Z-values for motif Tfcp2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfcp2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_57511833 32.363 ENSMUST00000067925.6
 Hmgb2
high mobility group box 2
chr11_+_69045640 23.433 ENSMUST00000108666.1
ENSMUST00000021277.5
 Aurkb

aurora kinase B

chr10_-_42583628 20.099 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr2_+_163225363 18.986 ENSMUST00000099110.3
ENSMUST00000165937.1
 Tox2

TOX high mobility group box family member 2

chr2_-_5012716 17.693 ENSMUST00000027980.7
 Mcm10
minichromosome maintenance deficient 10 (S. cerevisiae)
chr6_+_5390387 17.575 ENSMUST00000183358.1
 Asb4
ankyrin repeat and SOCS box-containing 4
chr11_-_22001605 17.062 ENSMUST00000006071.7
 Otx1
orthodenticle homolog 1 (Drosophila)
chr13_-_100786402 16.911 ENSMUST00000174038.1
ENSMUST00000091295.7
ENSMUST00000072119.8
 Ccnb1


cyclin B1


chr12_+_24708984 16.138 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr5_+_92809372 16.000 ENSMUST00000113054.2
 Shroom3
shroom family member 3
chr8_+_94172618 15.789 ENSMUST00000034214.6
 Mt2
metallothionein 2
chr1_+_44551483 15.555 ENSMUST00000074525.3
 Gulp1
GULP, engulfment adaptor PTB domain containing 1
chr18_+_11633276 13.328 ENSMUST00000115861.2
 Rbbp8
retinoblastoma binding protein 8
chr11_-_89302545 12.558 ENSMUST00000061728.3
 Nog
noggin
chr1_-_131097535 12.263 ENSMUST00000016672.4
 Mapkapk2
MAP kinase-activated protein kinase 2
chr16_-_26989974 11.919 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr12_-_91779129 11.659 ENSMUST00000170077.1
 Ston2
stonin 2
chr14_-_21989475 11.612 ENSMUST00000043409.7
 Zfp503
zinc finger protein 503
chr18_+_60925612 11.462 ENSMUST00000102888.3
ENSMUST00000025519.4
 Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr2_-_166155272 11.278 ENSMUST00000088086.3
 Sulf2
sulfatase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 135 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.1 40.3 GO:0035404 histone-serine phosphorylation(GO:0035404)
4.6 32.4 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.9 30.4 GO:0006270 DNA replication initiation(GO:0006270)
0.5 22.1 GO:0006911 phagocytosis, engulfment(GO:0006911)
1.3 21.5 GO:0030953 astral microtubule organization(GO:0030953)
1.3 21.1 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
5.0 20.1 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
4.0 20.1 GO:0021764 amygdala development(GO:0021764)
1.8 17.6 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
2.1 17.1 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.3 16.0 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
2.3 15.8 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.1 14.6 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.6 14.5 GO:0040034 regulation of development, heterochronic(GO:0040034)
2.7 13.3 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.2 13.3 GO:0002209 behavioral fear response(GO:0001662) behavioral defense response(GO:0002209)
3.1 12.6 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
2.0 12.3 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
1.2 11.9 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
2.9 11.7 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 70.3 GO:0005634 nucleus(GO:0005634)
0.0 39.7 GO:0005615 extracellular space(GO:0005615)
0.2 32.4 GO:0000793 condensed chromosome(GO:0000793)
4.7 23.4 GO:0032133 chromosome passenger complex(GO:0032133)
0.6 21.1 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 20.7 GO:0005813 centrosome(GO:0005813)
2.9 17.7 GO:0031298 replication fork protection complex(GO:0031298)
4.4 17.6 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
4.2 16.9 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.2 16.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 15.3 GO:0005925 focal adhesion(GO:0005925)
0.1 14.0 GO:0043296 apical junction complex(GO:0043296)
1.7 13.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
2.4 11.9 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 11.7 GO:0030136 clathrin-coated vesicle(GO:0030136)
1.8 11.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 11.1 GO:0015629 actin cytoskeleton(GO:0015629)
0.1 10.9 GO:0030027 lamellipodium(GO:0030027)
1.1 9.0 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 9.0 GO:0030863 cortical cytoskeleton(GO:0030863)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.1 30.7 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 25.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 23.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.7 23.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
3.3 23.4 GO:0035174 histone serine kinase activity(GO:0035174)
0.9 21.1 GO:0032794 GTPase activating protein binding(GO:0032794)
4.0 20.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.3 20.1 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 19.4 GO:0003682 chromatin binding(GO:0003682)
2.2 17.7 GO:0003688 DNA replication origin binding(GO:0003688)
3.4 16.9 GO:0005113 patched binding(GO:0005113)
0.1 15.1 GO:0051015 actin filament binding(GO:0051015)
0.3 14.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 13.4 GO:0048487 beta-tubulin binding(GO:0048487)
1.3 13.3 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
1.1 13.3 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.2 12.6 GO:0019955 cytokine binding(GO:0019955)
0.5 12.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 12.3 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
2.4 11.9 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)