Motif ID: Tfdp1_Wt1_Egr2

Z-value: 1.800

Transcription factors associated with Tfdp1_Wt1_Egr2:

Gene SymbolEntrez IDGene Name
Egr2 ENSMUSG00000037868.9 Egr2
Tfdp1 ENSMUSG00000038482.10 Tfdp1
Wt1 ENSMUSG00000016458.7 Wt1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfdp1mm10_v2_chr8_+_13339656_133396740.596.0e-08Click!
Egr2mm10_v2_chr10_+_67537861_675379300.132.8e-01Click!


Activity profile for motif Tfdp1_Wt1_Egr2.

activity profile for motif Tfdp1_Wt1_Egr2


Sorted Z-values histogram for motif Tfdp1_Wt1_Egr2

Sorted Z-values for motif Tfdp1_Wt1_Egr2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfdp1_Wt1_Egr2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_125490688 18.829 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr11_-_12037391 16.763 ENSMUST00000093321.5
 Grb10
growth factor receptor bound protein 10
chr13_+_48261427 15.427 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr2_-_156839790 13.726 ENSMUST00000134838.1
ENSMUST00000137463.1
ENSMUST00000149275.2
 Gm14230


predicted gene 14230


chr16_-_22163299 13.415 ENSMUST00000100052.4
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr18_-_80986578 13.222 ENSMUST00000057950.7
 Sall3
sal-like 3 (Drosophila)
chr19_+_38481057 13.104 ENSMUST00000182481.1
 Plce1
phospholipase C, epsilon 1
chr3_-_8667033 12.039 ENSMUST00000042412.3
 Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr5_+_108694222 11.699 ENSMUST00000013633.8
ENSMUST00000112560.3
 Fgfrl1

fibroblast growth factor receptor-like 1

chr4_+_154960915 11.696 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr7_+_117380937 11.509 ENSMUST00000032892.5
 Xylt1
xylosyltransferase 1
chr9_-_8004585 11.159 ENSMUST00000086580.5
ENSMUST00000065353.6
 Yap1

yes-associated protein 1

chr2_+_168081004 11.144 ENSMUST00000052125.6
 Pard6b
par-6 (partitioning defective 6) homolog beta (C. elegans)
chr13_-_29984219 10.786 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr8_+_12395287 10.351 ENSMUST00000180353.1
 Sox1
SRY-box containing gene 1
chr13_-_56252163 10.034 ENSMUST00000058475.4
 Neurog1
neurogenin 1
chr17_-_70851189 9.783 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr10_-_120476469 9.776 ENSMUST00000072777.7
ENSMUST00000159699.1
 Hmga2

high mobility group AT-hook 2

chr6_-_91411341 9.601 ENSMUST00000032180.6
 Wnt7a
wingless-related MMTV integration site 7A
chr7_-_25250720 9.569 ENSMUST00000116343.2
ENSMUST00000045847.8
 Erf

Ets2 repressor factor


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,198 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 34.5 GO:0006270 DNA replication initiation(GO:0006270)
3.5 31.8 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
1.8 28.8 GO:0038092 nodal signaling pathway(GO:0038092)
0.3 28.0 GO:0051028 mRNA transport(GO:0051028)
2.8 27.7 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
2.7 24.6 GO:0046499 S-adenosylmethioninamine metabolic process(GO:0046499)
3.3 23.1 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.7 22.2 GO:0006284 base-excision repair(GO:0006284)
1.8 19.8 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
4.8 19.3 GO:0003360 brainstem development(GO:0003360)
4.6 18.2 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
1.1 18.1 GO:0021889 olfactory bulb interneuron differentiation(GO:0021889)
1.4 17.9 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
3.5 17.3 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
3.4 17.0 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
1.7 16.9 GO:0008063 Toll signaling pathway(GO:0008063)
4.1 16.6 GO:0046836 glycolipid transport(GO:0046836)
4.1 16.3 GO:0060032 notochord regression(GO:0060032)
5.3 15.9 GO:0060364 frontal suture morphogenesis(GO:0060364)
0.7 15.9 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 357 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 330.1 GO:0005634 nucleus(GO:0005634)
0.4 96.8 GO:0005667 transcription factor complex(GO:0005667)
0.6 65.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.2 51.2 GO:0000790 nuclear chromatin(GO:0000790)
0.2 43.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.7 32.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 31.3 GO:0005925 focal adhesion(GO:0005925)
1.3 30.9 GO:0001741 XY body(GO:0001741)
0.5 29.1 GO:0005844 polysome(GO:0005844)
0.4 26.9 GO:0005643 nuclear pore(GO:0005643)
0.3 23.5 GO:0044291 cell-cell contact zone(GO:0044291)
0.5 22.1 GO:0031519 PcG protein complex(GO:0031519)
0.2 19.9 GO:0032432 actin filament bundle(GO:0032432)
1.2 19.3 GO:0016600 flotillin complex(GO:0016600)
0.3 19.3 GO:0005814 centriole(GO:0005814)
0.6 18.8 GO:0016592 mediator complex(GO:0016592)
6.1 18.3 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.5 17.7 GO:0044798 nuclear transcription factor complex(GO:0044798)
1.2 17.0 GO:0035631 CD40 receptor complex(GO:0035631)
1.2 15.4 GO:0097542 ciliary tip(GO:0097542)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 640 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 74.5 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.5 63.6 GO:0001047 core promoter binding(GO:0001047)
0.6 39.8 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
1.7 37.5 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 35.8 GO:0003677 DNA binding(GO:0003677)
1.6 34.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
3.4 30.9 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.5 30.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
1.6 27.6 GO:0017166 vinculin binding(GO:0017166)
1.6 25.7 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.9 25.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.3 24.3 GO:0008266 poly(U) RNA binding(GO:0008266)
3.0 24.1 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
2.9 22.8 GO:0046790 virion binding(GO:0046790)
1.2 22.6 GO:0033613 activating transcription factor binding(GO:0033613)
3.5 20.8 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.2 20.5 GO:0003774 motor activity(GO:0003774)
1.2 19.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
1.2 19.6 GO:0070410 co-SMAD binding(GO:0070410)
3.1 18.6 GO:0070644 vitamin D response element binding(GO:0070644)