Motif ID: Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Z-value: 1.066

Transcription factors associated with Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2:

Gene SymbolEntrez IDGene Name
Bhlhe41 ENSMUSG00000030256.5 Bhlhe41
Srebf1 ENSMUSG00000020538.9 Srebf1
Srebf2 ENSMUSG00000022463.7 Srebf2
Tfeb ENSMUSG00000023990.12 Tfeb
Usf1 ENSMUSG00000026641.7 Usf1
Usf2 ENSMUSG00000058239.7 Usf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Srebf1mm10_v2_chr11_-_60210410_602104650.405.1e-04Click!
Tfebmm10_v2_chr17_+_47737030_477371070.291.3e-02Click!
Srebf2mm10_v2_chr15_+_82147238_821472750.262.8e-02Click!
Usf2mm10_v2_chr7_-_30956742_309568030.235.1e-02Click!
Usf1mm10_v2_chr1_+_171411343_1714113840.142.4e-01Click!


Activity profile for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2.

activity profile for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2


Sorted Z-values histogram for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Sorted Z-values for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_89773221 15.369 ENSMUST00000038450.1
 4632404H12Rik
RIKEN cDNA 4632404H12 gene
chr17_-_66077022 12.166 ENSMUST00000150766.1
ENSMUST00000038116.5
 Ankrd12

ankyrin repeat domain 12

chr15_+_66577536 11.483 ENSMUST00000048188.8
 Phf20l1
PHD finger protein 20-like 1
chr15_-_3995708 10.225 ENSMUST00000046633.8
 AW549877
expressed sequence AW549877
chr4_-_148038769 9.819 ENSMUST00000030879.5
ENSMUST00000137724.1
 Clcn6

chloride channel 6

chr4_+_127077374 9.815 ENSMUST00000046751.6
ENSMUST00000094713.3
 Zmym6

zinc finger, MYM-type 6

chr16_-_45158566 9.097 ENSMUST00000181177.1
 Slc35a5
solute carrier family 35, member A5
chr10_+_111164794 8.923 ENSMUST00000105275.1
ENSMUST00000095310.1
 Osbpl8

oxysterol binding protein-like 8

chr16_-_45158650 8.723 ENSMUST00000023344.3
 Slc35a5
solute carrier family 35, member A5
chr10_+_41519493 8.380 ENSMUST00000019962.8
 Cd164
CD164 antigen
chr7_-_46795881 8.358 ENSMUST00000107653.1
ENSMUST00000107654.1
ENSMUST00000014562.7
ENSMUST00000152759.1
 Hps5



Hermansky-Pudlak syndrome 5 homolog (human)



chr16_-_45158624 8.314 ENSMUST00000180636.1
 Slc35a5
solute carrier family 35, member A5
chr16_-_45158183 8.234 ENSMUST00000114600.1
 Slc35a5
solute carrier family 35, member A5
chr7_+_35802593 8.166 ENSMUST00000052454.2
 E130304I02Rik
RIKEN cDNA E130304I02 gene
chr11_+_49203465 8.161 ENSMUST00000150284.1
ENSMUST00000109197.1
ENSMUST00000151228.1
 Zfp62


zinc finger protein 62


chr4_-_34882919 7.940 ENSMUST00000098163.2
ENSMUST00000047950.5
 Zfp292

zinc finger protein 292

chr17_+_26715644 7.936 ENSMUST00000062519.7
ENSMUST00000144221.1
ENSMUST00000142539.1
ENSMUST00000151681.1
 Crebrf



CREB3 regulatory factor



chr16_-_45158453 7.831 ENSMUST00000181750.1
 Slc35a5
solute carrier family 35, member A5
chr18_-_6135888 7.728 ENSMUST00000182383.1
ENSMUST00000062584.7
ENSMUST00000077128.6
ENSMUST00000182038.1
ENSMUST00000182213.1
 Arhgap12




Rho GTPase activating protein 12




chr2_-_79456750 7.703 ENSMUST00000041099.4
 Neurod1
neurogenic differentiation 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 365 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 46.3 GO:0008643 carbohydrate transport(GO:0008643)
0.6 18.4 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.4 16.8 GO:0036465 synaptic vesicle recycling(GO:0036465)
4.9 14.6 GO:1901254 positive regulation of intracellular transport of viral material(GO:1901254)
0.2 14.3 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.2 14.3 GO:0043473 pigmentation(GO:0043473)
3.2 12.8 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
3.1 12.6 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.6 11.4 GO:0097576 autophagosome maturation(GO:0097352) vacuole fusion(GO:0097576)
0.3 11.1 GO:1902476 chloride transmembrane transport(GO:1902476)
0.4 10.5 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
1.5 10.4 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.2 10.0 GO:0002011 morphogenesis of an epithelial sheet(GO:0002011)
0.8 9.1 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
2.2 8.9 GO:0010891 negative regulation of sequestering of triglyceride(GO:0010891)
1.8 8.9 GO:1905049 negative regulation of metalloendopeptidase activity(GO:1904684) negative regulation of metallopeptidase activity(GO:1905049)
2.9 8.8 GO:0051542 elastin biosynthetic process(GO:0051542)
1.3 8.8 GO:0048102 autophagic cell death(GO:0048102)
0.2 8.8 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.5 8.6 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 184 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 60.0 GO:0016021 integral component of membrane(GO:0016021)
0.1 35.9 GO:0000139 Golgi membrane(GO:0000139)
3.9 15.5 GO:0031084 BLOC-2 complex(GO:0031084)
0.1 15.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
4.9 14.6 GO:0042025 viral replication complex(GO:0019034) host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.9 12.8 GO:0043196 varicosity(GO:0043196)
0.2 12.5 GO:0042734 presynaptic membrane(GO:0042734)
0.2 12.5 GO:0005776 autophagosome(GO:0005776)
0.2 11.5 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 11.4 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
1.2 10.8 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.9 9.9 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.3 9.6 GO:0035861 site of double-strand break(GO:0035861)
1.4 9.5 GO:0033263 CORVET complex(GO:0033263)
1.2 9.2 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
1.8 8.9 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 8.7 GO:0031526 brush border membrane(GO:0031526)
0.4 7.6 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 7.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 7.6 GO:0045202 synapse(GO:0045202)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 251 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 43.5 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.8 21.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 20.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 18.2 GO:0005096 GTPase activator activity(GO:0005096)
0.2 17.7 GO:0008565 protein transporter activity(GO:0008565)
0.1 17.4 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.2 15.6 GO:0005262 calcium channel activity(GO:0005262)
2.7 13.6 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.8 13.0 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.4 12.8 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
2.1 12.6 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.2 12.4 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.7 12.1 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.1 10.8 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 9.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.3 9.0 GO:0050681 androgen receptor binding(GO:0050681)
2.9 8.8 GO:0004008 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.1 8.6 GO:0019905 syntaxin binding(GO:0019905)
0.8 8.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
2.7 8.1 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)