Motif ID: Tgif1_Meis3

Z-value: 3.508

Transcription factors associated with Tgif1_Meis3:

Gene SymbolEntrez IDGene Name
Meis3 ENSMUSG00000041420.12 Meis3
Tgif1 ENSMUSG00000047407.11 Tgif1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tgif1mm10_v2_chr17_-_70853482_70853546-0.912.0e-28Click!
Meis3mm10_v2_chr7_+_16175085_161751390.736.6e-13Click!


Activity profile for motif Tgif1_Meis3.

activity profile for motif Tgif1_Meis3


Sorted Z-values histogram for motif Tgif1_Meis3

Sorted Z-values for motif Tgif1_Meis3



Network of associatons between targets according to the STRING database.



First level regulatory network of Tgif1_Meis3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_132542934 61.175 ENSMUST00000086521.4
 Cntn2
contactin 2
chr7_+_49246131 56.492 ENSMUST00000064395.6
 Nav2
neuron navigator 2
chr15_-_66831625 47.453 ENSMUST00000164163.1
 Sla
src-like adaptor
chr15_-_66801577 39.914 ENSMUST00000168589.1
 Sla
src-like adaptor
chr6_-_88874045 34.484 ENSMUST00000038409.5
 Podxl2
podocalyxin-like 2
chr19_+_23758819 33.375 ENSMUST00000025830.7
 Apba1
amyloid beta (A4) precursor protein binding, family A, member 1
chr3_+_26331150 32.526 ENSMUST00000099182.2
 A830092H15Rik
RIKEN cDNA A830092H15 gene
chr15_+_18818895 32.282 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr8_-_84800024 29.584 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X

chr11_+_98348404 27.404 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr12_-_24493656 27.232 ENSMUST00000073088.2
 Gm16372
predicted pseudogene 16372
chr1_+_194619815 27.055 ENSMUST00000027952.5
 Plxna2
plexin A2
chr11_+_105589970 27.023 ENSMUST00000168598.1
ENSMUST00000100330.3
 Tanc2

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

chr2_-_168712853 25.707 ENSMUST00000123156.1
ENSMUST00000156555.1
 Atp9a

ATPase, class II, type 9A

chr4_-_82705735 25.018 ENSMUST00000155821.1
 Nfib
nuclear factor I/B
chr7_+_49246812 24.541 ENSMUST00000184945.1
 Nav2
neuron navigator 2
chr16_-_18621366 23.498 ENSMUST00000051160.2
 Gp1bb
glycoprotein Ib, beta polypeptide
chr19_+_28835074 23.490 ENSMUST00000025875.4
 Slc1a1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr1_-_162478004 22.657 ENSMUST00000086074.5
ENSMUST00000070330.7
 Dnm3

dynamin 3

chr3_-_123672321 22.492 ENSMUST00000172537.1
ENSMUST00000029602.6
 Ndst3

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 598 entries
Log-likelihood per target Total log-likelihoodTermDescription
20.3 81.0 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
2.4 73.3 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
1.5 62.6 GO:0006376 mRNA splice site selection(GO:0006376)
12.2 61.2 GO:0031133 regulation of axon diameter(GO:0031133)
5.5 55.0 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
4.1 53.5 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
2.4 47.1 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
1.2 46.6 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
2.9 44.2 GO:0050901 leukocyte tethering or rolling(GO:0050901)
3.5 42.4 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
14.1 42.3 GO:0016191 synaptic vesicle uncoating(GO:0016191) regulation of endosome organization(GO:1904978) positive regulation of endosome organization(GO:1904980)
2.4 41.3 GO:0021860 pyramidal neuron development(GO:0021860)
1.3 41.2 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.5 37.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
2.7 35.0 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
2.4 33.7 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
3.6 32.4 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.3 32.1 GO:0007612 learning(GO:0007612)
0.3 30.8 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
1.8 29.8 GO:0006744 ubiquinone biosynthetic process(GO:0006744)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 220 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 428.7 GO:0016021 integral component of membrane(GO:0016021)
0.7 156.7 GO:0045211 postsynaptic membrane(GO:0045211)
3.5 86.9 GO:0030132 clathrin coat of coated pit(GO:0030132)
3.2 80.4 GO:0071565 nBAF complex(GO:0071565)
4.8 77.4 GO:0005614 interstitial matrix(GO:0005614)
3.4 68.7 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.2 68.6 GO:0005768 endosome(GO:0005768)
0.5 54.3 GO:0055037 recycling endosome(GO:0055037)
0.3 52.3 GO:0030427 site of polarized growth(GO:0030427)
1.6 46.6 GO:0033268 node of Ranvier(GO:0033268)
0.9 45.1 GO:0042734 presynaptic membrane(GO:0042734)
1.3 44.4 GO:0048786 presynaptic active zone(GO:0048786)
1.9 43.9 GO:0000930 gamma-tubulin complex(GO:0000930)
3.1 40.6 GO:0016342 catenin complex(GO:0016342)
0.3 39.8 GO:0060076 excitatory synapse(GO:0060076)
2.8 36.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
1.1 34.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
2.9 31.9 GO:0043083 synaptic cleft(GO:0043083)
0.2 28.9 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.5 28.4 GO:0043198 dendritic shaft(GO:0043198)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 382 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 113.7 GO:0030552 cAMP binding(GO:0030552)
0.4 64.9 GO:0003714 transcription corepressor activity(GO:0003714)
1.5 64.8 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
1.0 58.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
2.6 55.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
1.3 52.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.3 45.3 GO:0017137 Rab GTPase binding(GO:0017137)
4.9 44.5 GO:0032050 clathrin heavy chain binding(GO:0032050)
6.2 43.2 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.8 41.3 GO:0043621 protein self-association(GO:0043621)
1.4 40.3 GO:0030215 semaphorin receptor binding(GO:0030215)
1.4 39.0 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 37.9 GO:0005509 calcium ion binding(GO:0005509)
3.8 37.6 GO:0052872 3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) phenanthrene 9,10-monooxygenase activity(GO:0018636) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) tocotrienol omega-hydroxylase activity(GO:0052872) thalianol hydroxylase activity(GO:0080014)
2.7 37.2 GO:0017154 semaphorin receptor activity(GO:0017154)
1.4 35.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 32.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.4 31.8 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.2 31.0 GO:0008017 microtubule binding(GO:0008017)
0.5 29.9 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)