Motif ID: Thrb

Z-value: 0.443


Transcription factors associated with Thrb:

Gene SymbolEntrez IDGene Name
Thrb ENSMUSG00000021779.10 Thrb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Thrbmm10_v2_chr14_+_17660956_17660963-0.047.5e-01Click!


Activity profile for motif Thrb.

activity profile for motif Thrb


Sorted Z-values histogram for motif Thrb

Sorted Z-values for motif Thrb



Network of associatons between targets according to the STRING database.



First level regulatory network of Thrb

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_105399286 4.783 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr9_-_107668967 4.561 ENSMUST00000177567.1
 Slc38a3
solute carrier family 38, member 3
chr3_+_14863495 4.132 ENSMUST00000029076.4
 Car3
carbonic anhydrase 3
chr3_+_67374091 3.324 ENSMUST00000077916.5
 Mlf1
myeloid leukemia factor 1
chr3_-_36475688 3.171 ENSMUST00000029266.8
 Anxa5
annexin A5
chr3_+_67374116 3.128 ENSMUST00000061322.8
 Mlf1
myeloid leukemia factor 1
chr5_-_92278155 3.029 ENSMUST00000159345.1
ENSMUST00000113102.3
 Naaa

N-acylethanolamine acid amidase

chr11_-_115612491 2.709 ENSMUST00000106507.2
 Mif4gd
MIF4G domain containing
chr3_-_79842662 2.575 ENSMUST00000029568.1
 Tmem144
transmembrane protein 144
chr11_+_109485606 2.038 ENSMUST00000106697.1
 Arsg
arylsulfatase G
chr12_+_108334341 2.028 ENSMUST00000021684.4
 Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr2_-_25470031 1.934 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chrX_+_112311334 1.761 ENSMUST00000026599.3
ENSMUST00000113415.1
 Apool

apolipoprotein O-like

chr4_+_20042046 1.602 ENSMUST00000098242.3
 Ggh
gamma-glutamyl hydrolase
chr2_-_25469742 1.597 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr12_+_112620030 1.552 ENSMUST00000180015.1
ENSMUST00000021726.6
 Adssl1

adenylosuccinate synthetase like 1

chr15_-_103251465 1.370 ENSMUST00000133600.1
ENSMUST00000134554.1
ENSMUST00000156927.1
ENSMUST00000149111.1
ENSMUST00000132836.1
 Nfe2




nuclear factor, erythroid derived 2




chrX_-_78583882 1.099 ENSMUST00000114025.1
ENSMUST00000134602.1
ENSMUST00000114024.2
 Prrg1


proline rich Gla (G-carboxyglutamic acid) 1


chr2_+_152962485 1.038 ENSMUST00000099197.2
ENSMUST00000103155.3
 Ttll9

tubulin tyrosine ligase-like family, member 9

chr16_+_32419696 0.978 ENSMUST00000014220.8
ENSMUST00000080316.7
 Tctex1d2

Tctex1 domain containing 2

chrX_-_78583782 0.926 ENSMUST00000177904.1
 Prrg1
proline rich Gla (G-carboxyglutamic acid) 1
chr9_+_102626278 0.887 ENSMUST00000038673.7
 Anapc13
anaphase promoting complex subunit 13
chr16_+_37916440 0.811 ENSMUST00000061274.7
 Gpr156
G protein-coupled receptor 156
chr2_-_24049389 0.663 ENSMUST00000051416.5
 Hnmt
histamine N-methyltransferase
chr1_+_87214286 0.625 ENSMUST00000113231.3
 Eif4e2
eukaryotic translation initiation factor 4E member 2
chr9_-_102626509 0.557 ENSMUST00000161645.1
ENSMUST00000162297.1
ENSMUST00000162655.1
 Cep63


centrosomal protein 63


chr16_+_36934976 0.544 ENSMUST00000023531.8
 Hcls1
hematopoietic cell specific Lyn substrate 1
chr4_-_148444744 0.527 ENSMUST00000051633.2
 Ubiad1
UbiA prenyltransferase domain containing 1
chr1_-_137969213 0.519 ENSMUST00000182680.1
ENSMUST00000182424.1
 Gm26936

predicted gene, 26936

chr1_+_87213924 0.503 ENSMUST00000113230.1
ENSMUST00000123735.1
 Eif4e2

eukaryotic translation initiation factor 4E member 2

chr11_-_103344651 0.394 ENSMUST00000041385.7
 Arhgap27
Rho GTPase activating protein 27
chr9_-_102626095 0.369 ENSMUST00000093791.3
 Cep63
centrosomal protein 63
chr15_-_100669496 0.293 ENSMUST00000182814.1
ENSMUST00000182068.1
 Bin2

bridging integrator 2

chr3_-_116712198 0.222 ENSMUST00000120120.1
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr5_+_130219706 0.158 ENSMUST00000065329.6
 Tmem248
transmembrane protein 248
chr5_-_111761697 0.110 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr9_+_95857597 0.089 ENSMUST00000034980.7
 Atr
ataxia telangiectasia and Rad3 related
chr2_+_119167758 0.054 ENSMUST00000057454.3
 Gchfr
GTP cyclohydrolase I feedback regulator

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.6 GO:0006867 asparagine transport(GO:0006867) glutamine transport(GO:0006868)
0.8 3.2 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.7 6.5 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.7 3.5 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.5 1.6 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.3 1.6 GO:0006167 AMP biosynthetic process(GO:0006167)
0.2 2.0 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 1.4 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.1 0.5 GO:0042373 vitamin K metabolic process(GO:0042373)
0.1 0.9 GO:0090220 meiotic telomere clustering(GO:0045141) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.1 4.1 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 1.8 GO:0042407 cristae formation(GO:0042407)
0.1 0.1 GO:1904884 establishment of RNA localization to telomere(GO:0097694) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.1 0.5 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.2 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.0 0.9 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 4.6 GO:0043010 camera-type eye development(GO:0043010)
0.0 0.3 GO:0071800 podosome assembly(GO:0071800)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 GO:0061617 MICOS complex(GO:0061617)
0.1 1.1 GO:0034518 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.1 6.5 GO:0031514 motile cilium(GO:0031514)
0.0 3.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 3.2 GO:0014704 intercalated disc(GO:0014704)
0.0 0.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 4.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 6.7 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 0.3 GO:0001891 phagocytic cup(GO:0001891)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.6 GO:0015186 L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.9 3.5 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.4 4.1 GO:0016151 nickel cation binding(GO:0016151)
0.3 2.0 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.2 3.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.2 0.5 GO:0048045 4-hydroxybenzoate octaprenyltransferase activity(GO:0008412) protoheme IX farnesyltransferase activity(GO:0008495) (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity(GO:0043888) cadaverine aminopropyltransferase activity(GO:0043918) agmatine aminopropyltransferase activity(GO:0043919) 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity(GO:0046428) trans-pentaprenyltranstransferase activity(GO:0048045) ATP dimethylallyltransferase activity(GO:0052622) ADP dimethylallyltransferase activity(GO:0052623)
0.1 3.0 GO:0043747 protein-N-terminal asparagine amidohydrolase activity(GO:0008418) UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity(GO:0008759) iprodione amidohydrolase activity(GO:0018748) (3,5-dichlorophenylurea)acetate amidohydrolase activity(GO:0018749) 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity(GO:0034571) didemethylisoproturon amidohydrolase activity(GO:0034573) N-isopropylacetanilide amidohydrolase activity(GO:0034576) N-cyclohexylformamide amidohydrolase activity(GO:0034781) isonicotinic acid hydrazide hydrolase activity(GO:0034876) cis-aconitamide amidase activity(GO:0034882) gamma-N-formylaminovinylacetate hydrolase activity(GO:0034885) N2-acetyl-L-lysine deacetylase activity(GO:0043747) O-succinylbenzoate synthase activity(GO:0043748) indoleacetamide hydrolase activity(GO:0043864) N-acetylcitrulline deacetylase activity(GO:0043909) N-acetylgalactosamine-6-phosphate deacetylase activity(GO:0047419) diacetylchitobiose deacetylase activity(GO:0052773) chitooligosaccharide deacetylase activity(GO:0052790)
0.1 0.8 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 2.0 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 1.6 GO:0008242 omega peptidase activity(GO:0008242)
0.0 1.4 GO:0050699 WW domain binding(GO:0050699)
0.0 1.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.1 GO:0032405 MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407)