Motif ID: Tlx1

Z-value: 0.702


Transcription factors associated with Tlx1:

Gene SymbolEntrez IDGene Name
Tlx1 ENSMUSG00000025215.9 Tlx1



Activity profile for motif Tlx1.

activity profile for motif Tlx1


Sorted Z-values histogram for motif Tlx1

Sorted Z-values for motif Tlx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tlx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_25470031 6.525 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr12_+_95692212 6.150 ENSMUST00000057324.3
 Flrt2
fibronectin leucine rich transmembrane protein 2
chr1_+_185454803 6.038 ENSMUST00000061093.6
 Slc30a10
solute carrier family 30, member 10
chr6_-_115251839 5.920 ENSMUST00000032462.6
 Timp4
tissue inhibitor of metalloproteinase 4
chr6_+_54681687 5.859 ENSMUST00000046276.6
 2410066E13Rik
RIKEN cDNA 2410066E13 gene
chr8_-_109251698 5.737 ENSMUST00000079189.3
 4922502B01Rik
RIKEN cDNA 4922502B01 gene
chr11_+_97450136 5.210 ENSMUST00000107601.1
 Arhgap23
Rho GTPase activating protein 23
chr1_+_43730593 5.139 ENSMUST00000027217.8
 1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr12_-_112511136 5.043 ENSMUST00000066791.5
 Tmem179
transmembrane protein 179
chr17_+_8340710 4.987 ENSMUST00000163887.1
 Prr18
proline rich region 18
chr7_-_97417730 4.942 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr6_+_55451978 4.804 ENSMUST00000070736.5
ENSMUST00000070756.5
ENSMUST00000166962.1
 Adcyap1r1


adenylate cyclase activating polypeptide 1 receptor 1


chr6_+_55452177 4.773 ENSMUST00000167484.1
 Adcyap1r1
adenylate cyclase activating polypeptide 1 receptor 1
chr4_+_48045144 4.597 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr12_-_78983476 4.556 ENSMUST00000070174.7
 Tmem229b
transmembrane protein 229B
chr11_+_3488275 4.524 ENSMUST00000064265.6
 Pla2g3
phospholipase A2, group III
chr11_-_116654245 4.377 ENSMUST00000021166.5
 Cygb
cytoglobin
chrX_-_73880831 4.107 ENSMUST00000102871.3
 L1cam
L1 cell adhesion molecule
chr2_-_164404606 4.005 ENSMUST00000109359.1
ENSMUST00000109358.1
ENSMUST00000103103.3
 Matn4


matrilin 4


chr3_+_156562141 3.785 ENSMUST00000175773.1
 Negr1
neuronal growth regulator 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 9.6 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
1.9 9.4 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.1 8.8 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
1.3 7.9 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
0.9 7.2 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
1.3 6.5 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
1.0 6.1 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.7 6.0 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.6 5.1 GO:0070314 G1 to G0 transition(GO:0070314)
0.2 4.9 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
1.5 4.6 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
1.1 4.5 GO:0019372 lipoxygenase pathway(GO:0019372)
0.9 4.4 GO:0015671 oxygen transport(GO:0015671)
0.1 4.4 GO:0007608 sensory perception of smell(GO:0007608)
0.4 4.1 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.1 4.0 GO:0048678 response to axon injury(GO:0048678)
0.0 4.0 GO:0051260 protein homooligomerization(GO:0051260)
0.6 3.9 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
1.2 3.7 GO:1904049 regulation of spontaneous neurotransmitter secretion(GO:1904048) negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.2 3.7 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
1.1 7.9 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.2 6.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 6.1 GO:0005871 kinesin complex(GO:0005871)
0.1 5.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 5.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 5.3 GO:0030017 sarcomere(GO:0030017)
0.1 4.8 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 4.3 GO:0005911 cell-cell junction(GO:0005911)
0.1 4.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 4.1 GO:0044295 axonal growth cone(GO:0044295)
0.0 3.9 GO:0000139 Golgi membrane(GO:0000139)
0.7 3.7 GO:1990761 growth cone lamellipodium(GO:1990761)
0.0 3.4 GO:0055037 recycling endosome(GO:0055037)
0.0 3.2 GO:0005929 cilium(GO:0005929)
0.0 3.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 2.9 GO:0034451 centriolar satellite(GO:0034451)
0.0 2.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.8 GO:0034704 calcium channel complex(GO:0034704)
0.2 2.7 GO:0031045 dense core granule(GO:0031045)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 9.6 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.7 9.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.3 7.9 GO:0051787 misfolded protein binding(GO:0051787)
0.1 6.9 GO:0003777 microtubule motor activity(GO:0003777)
1.6 6.5 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.8 6.2 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.3 6.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.2 5.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.3 5.5 GO:0042056 chemoattractant activity(GO:0042056)
0.3 5.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 5.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 5.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 4.6 GO:0001223 transcription coactivator binding(GO:0001223)
1.1 4.4 GO:0004096 catalase activity(GO:0004096)
0.8 4.1 GO:0033691 sialic acid binding(GO:0033691)
0.6 3.9 GO:0015265 urea channel activity(GO:0015265)
0.6 3.7 GO:0016453 acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.1 3.6 GO:0031593 polyubiquitin binding(GO:0031593)
0.9 3.5 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.1 3.4 GO:0005158 insulin receptor binding(GO:0005158)