Motif ID: Tlx2

Z-value: 0.934


Transcription factors associated with Tlx2:

Gene SymbolEntrez IDGene Name
Tlx2 ENSMUSG00000068327.3 Tlx2



Activity profile for motif Tlx2.

activity profile for motif Tlx2


Sorted Z-values histogram for motif Tlx2

Sorted Z-values for motif Tlx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tlx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48662740 7.566 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr16_+_91225550 7.049 ENSMUST00000035608.8
 Olig2
oligodendrocyte transcription factor 2
chr10_+_79988584 4.516 ENSMUST00000004784.4
ENSMUST00000105374.1
 Cnn2

calponin 2

chr8_+_94772009 4.116 ENSMUST00000034230.5
 Cx3cl1
chemokine (C-X3-C motif) ligand 1
chr10_-_103028771 4.051 ENSMUST00000040859.5
 Alx1
ALX homeobox 1
chr3_+_134236483 4.001 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr3_-_145649970 3.904 ENSMUST00000029846.3
 Cyr61
cysteine rich protein 61
chr11_-_52282564 3.655 ENSMUST00000086844.3
 Tcf7
transcription factor 7, T cell specific
chr3_+_159839729 3.497 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr19_-_24031006 3.280 ENSMUST00000096164.4
 Fam189a2
family with sequence similarity 189, member A2
chr4_+_154960915 3.235 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr5_+_146845071 3.097 ENSMUST00000031646.7
 Rasl11a
RAS-like, family 11, member A
chr18_-_31949571 2.973 ENSMUST00000064016.5
 Gpr17
G protein-coupled receptor 17
chr3_-_36475688 2.926 ENSMUST00000029266.8
 Anxa5
annexin A5
chr11_-_51650813 2.867 ENSMUST00000142721.1
ENSMUST00000156835.1
ENSMUST00000001080.9
 N4bp3


NEDD4 binding protein 3


chr6_+_108660772 2.819 ENSMUST00000163617.1
 Bhlhe40
basic helix-loop-helix family, member e40
chr14_-_48667508 2.780 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr10_-_67912620 2.770 ENSMUST00000064656.7
 Zfp365
zinc finger protein 365
chr6_-_72390659 2.746 ENSMUST00000059983.9
 Vamp8
vesicle-associated membrane protein 8
chr6_+_108660616 2.590 ENSMUST00000032194.4
 Bhlhe40
basic helix-loop-helix family, member e40

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 217 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 10.3 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
2.3 7.0 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.2 5.5 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.2 5.4 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
1.6 4.8 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
1.2 4.7 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.7 4.3 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
1.0 4.1 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.4 4.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 3.9 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
1.3 3.8 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
1.2 3.7 GO:1903048 regulation of acetylcholine-gated cation channel activity(GO:1903048)
0.5 3.7 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.3 3.5 GO:0031017 exocrine pancreas development(GO:0031017)
0.1 3.4 GO:0070206 protein trimerization(GO:0070206)
0.8 3.2 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.4 3.2 GO:0046645 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474)
0.5 3.1 GO:0036233 glycine import(GO:0036233)
0.3 3.1 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.1 3.1 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.9 GO:0005794 Golgi apparatus(GO:0005794)
0.0 10.5 GO:0005667 transcription factor complex(GO:0005667)
0.1 8.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 5.6 GO:0030426 growth cone(GO:0030426)
0.0 5.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.3 4.7 GO:0043205 fibril(GO:0043205)
0.0 4.6 GO:0043209 myelin sheath(GO:0043209)
0.4 4.3 GO:0005642 annulate lamellae(GO:0005642)
0.2 4.2 GO:0000242 pericentriolar material(GO:0000242)
0.1 4.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.3 4.1 GO:0035686 sperm fibrous sheath(GO:0035686)
0.3 3.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 3.6 GO:0032432 actin filament bundle(GO:0032432)
0.6 3.0 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 3.0 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1 2.9 GO:0014704 intercalated disc(GO:0014704)
0.0 2.9 GO:0016324 apical plasma membrane(GO:0016324)
0.1 2.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 2.8 GO:0043218 compact myelin(GO:0043218)
0.0 2.8 GO:0000139 Golgi membrane(GO:0000139)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 154 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 8.5 GO:0030165 PDZ domain binding(GO:0030165)
0.0 7.7 GO:0005525 GTP binding(GO:0005525)
0.2 7.0 GO:0071837 HMG box domain binding(GO:0071837)
0.1 6.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.3 6.0 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.9 5.4 GO:0043426 MRF binding(GO:0043426)
0.0 5.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 4.9 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.9 4.7 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.3 4.4 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 4.3 GO:0008013 beta-catenin binding(GO:0008013)
0.7 4.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 4.1 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.3 3.7 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.3 3.5 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.6 3.2 GO:0042610 CD8 receptor binding(GO:0042610)
0.1 3.2 GO:0004896 cytokine receptor activity(GO:0004896)
0.5 3.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.6 3.0 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)