Motif ID: Trp53

Z-value: 1.131


Transcription factors associated with Trp53:

Gene SymbolEntrez IDGene Name
Trp53 ENSMUSG00000059552.7 Trp53

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Trp53mm10_v2_chr11_+_69580392_695804190.491.7e-05Click!


Activity profile for motif Trp53.

activity profile for motif Trp53


Sorted Z-values histogram for motif Trp53

Sorted Z-values for motif Trp53



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp53

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Showing 1 to 20 of 143 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_69206146 19.371 ENSMUST00000127243.1
ENSMUST00000149643.1
ENSMUST00000167875.2
ENSMUST00000005365.8
Spc25



SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)



chr17_-_33890584 17.322 ENSMUST00000114361.2
ENSMUST00000173492.1
Kifc1

kinesin family member C1

chr15_-_98004695 17.153 ENSMUST00000023123.8
Col2a1
collagen, type II, alpha 1
chr15_-_98004634 16.714 ENSMUST00000131560.1
ENSMUST00000088355.5
Col2a1

collagen, type II, alpha 1

chr17_-_33890539 16.079 ENSMUST00000173386.1
Kifc1
kinesin family member C1
chr2_-_69206133 15.462 ENSMUST00000112320.1
Spc25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr8_-_22185758 13.123 ENSMUST00000046916.7
Ckap2
cytoskeleton associated protein 2
chr15_+_85859689 10.393 ENSMUST00000170629.1
Gtse1
G two S phase expressed protein 1
chr11_-_102925086 10.117 ENSMUST00000021311.9
Kif18b
kinesin family member 18B
chr1_+_6487231 9.758 ENSMUST00000140079.1
ENSMUST00000131494.1
St18

suppression of tumorigenicity 18

chr14_+_73237891 8.904 ENSMUST00000044405.6
Lpar6
lysophosphatidic acid receptor 6
chr8_+_94977101 8.879 ENSMUST00000179619.1
Gpr56
G protein-coupled receptor 56
chr1_-_79858627 8.686 ENSMUST00000027467.4
Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr10_+_56377300 8.258 ENSMUST00000068581.7
Gja1
gap junction protein, alpha 1
chr14_+_47001336 7.527 ENSMUST00000125113.1
Samd4
sterile alpha motif domain containing 4
chr5_-_30073554 7.341 ENSMUST00000026846.6
Tyms
thymidylate synthase
chr2_+_59612034 7.097 ENSMUST00000112568.1
ENSMUST00000037526.4
Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr3_-_75956888 7.050 ENSMUST00000038563.7
ENSMUST00000167078.1
ENSMUST00000117242.1
Golim4


golgi integral membrane protein 4


chr14_-_103843685 7.008 ENSMUST00000172237.1
Ednrb
endothelin receptor type B
chr5_-_116422858 6.963 ENSMUST00000036991.4
Hspb8
heat shock protein 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 38.3 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.4 34.8 GO:0007052 mitotic spindle organization(GO:0007052)
8.4 33.4 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.4 23.2 GO:0007019 microtubule depolymerization(GO:0007019)
0.9 13.3 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.8 12.8 GO:0070986 left/right axis specification(GO:0070986)
2.9 8.7 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
2.8 8.3 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
2.4 7.3 GO:0046078 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) dUMP metabolic process(GO:0046078)
0.4 7.1 GO:0097062 dendritic spine maintenance(GO:0097062)
2.3 7.0 GO:0014826 vein smooth muscle contraction(GO:0014826)
1.4 6.9 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.9 6.8 GO:0071493 cellular response to UV-B(GO:0071493)
0.1 6.7 GO:0045727 positive regulation of translation(GO:0045727)
0.2 5.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 5.3 GO:1902017 regulation of cilium assembly(GO:1902017)
0.1 5.2 GO:0000186 activation of MAPKK activity(GO:0000186)
1.2 4.9 GO:0099624 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372) atrial cardiac muscle cell membrane repolarization(GO:0099624)
0.0 4.8 GO:0009566 fertilization(GO:0009566)
1.6 4.7 GO:0060217 hemangioblast cell differentiation(GO:0060217)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.8 34.8 GO:0031262 Ndc80 complex(GO:0031262)
2.6 33.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
2.1 33.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.4 23.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
3.3 13.3 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.2 10.4 GO:0005882 intermediate filament(GO:0005882)
0.1 10.3 GO:0043679 axon terminus(GO:0043679)
1.7 10.1 GO:0000235 astral microtubule(GO:0000235)
0.9 9.0 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.8 8.7 GO:0031091 platelet alpha granule(GO:0031091) extrinsic component of external side of plasma membrane(GO:0031232)
0.8 8.3 GO:0005916 fascia adherens(GO:0005916)
0.0 8.1 GO:0019866 mitochondrial inner membrane(GO:0005743) organelle inner membrane(GO:0019866)
0.0 8.0 GO:0031965 nuclear membrane(GO:0031965)
2.3 6.8 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 6.7 GO:0005604 basement membrane(GO:0005604)
0.1 5.8 GO:0005871 kinesin complex(GO:0005871)
0.1 5.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.6 4.7 GO:0033193 Lsd1/2 complex(GO:0033193)
0.1 4.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.4 4.5 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 33.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
8.4 33.4 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.6 13.3 GO:0000400 four-way junction DNA binding(GO:0000400)
0.7 10.1 GO:1990939 ATP-dependent microtubule motor activity(GO:1990939)
0.2 8.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.7 8.3 GO:0071253 connexin binding(GO:0071253)
0.3 7.5 GO:0030371 translation repressor activity(GO:0030371)
0.4 7.3 GO:0005542 folic acid binding(GO:0005542)
2.3 7.0 GO:0004962 endothelin receptor activity(GO:0004962)
1.0 6.9 GO:0043237 laminin-1 binding(GO:0043237)
0.5 6.8 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 6.0 GO:0031490 chromatin DNA binding(GO:0031490)
1.0 5.9 GO:0008494 translation activator activity(GO:0008494)
0.1 5.8 GO:0003777 microtubule motor activity(GO:0003777)
0.1 5.6 GO:0017124 SH3 domain binding(GO:0017124)
0.1 5.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 5.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 5.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
1.0 4.9 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.1 4.7 GO:0070888 E-box binding(GO:0070888)