Motif ID: Trp63

Z-value: 0.707


Transcription factors associated with Trp63:

Gene SymbolEntrez IDGene Name
Trp63 ENSMUSG00000022510.8 Trp63



Activity profile for motif Trp63.

activity profile for motif Trp63


Sorted Z-values histogram for motif Trp63

Sorted Z-values for motif Trp63



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp63

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_116038734 11.790 ENSMUST00000166877.1
 Sox6
SRY-box containing gene 6
chr1_-_9700209 5.831 ENSMUST00000088658.4
 Mybl1
myeloblastosis oncogene-like 1
chr7_-_141443314 4.341 ENSMUST00000106005.2
 Lrdd
leucine-rich and death domain containing
chr4_-_96591555 4.195 ENSMUST00000055693.8
 Cyp2j9
cytochrome P450, family 2, subfamily j, polypeptide 9
chr19_-_5875268 4.192 ENSMUST00000025728.6
 Frmd8
FERM domain containing 8
chr19_+_53140430 4.080 ENSMUST00000111741.2
 Add3
adducin 3 (gamma)
chr6_+_34709610 4.044 ENSMUST00000031775.6
 Cald1
caldesmon 1
chr2_+_59612034 4.025 ENSMUST00000112568.1
ENSMUST00000037526.4
 Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr19_-_5875210 4.008 ENSMUST00000155227.1
 Frmd8
FERM domain containing 8
chr8_-_87959560 3.916 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr11_-_69948145 3.890 ENSMUST00000179298.1
ENSMUST00000018710.6
ENSMUST00000135437.1
ENSMUST00000141837.2
ENSMUST00000142500.1
 Slc2a4




solute carrier family 2 (facilitated glucose transporter), member 4




chr15_-_8710409 3.884 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr6_+_34709442 3.671 ENSMUST00000115021.1
 Cald1
caldesmon 1
chr7_-_37772868 3.545 ENSMUST00000176205.1
 Zfp536
zinc finger protein 536
chr17_+_29090969 3.293 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr2_-_170427828 3.128 ENSMUST00000013667.2
ENSMUST00000109152.2
ENSMUST00000068137.4
 Bcas1


breast carcinoma amplified sequence 1


chr4_-_134018829 2.683 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr14_-_122451109 2.546 ENSMUST00000081580.2
 Gm5089
predicted gene 5089
chr5_-_5265224 2.356 ENSMUST00000115450.1
 Cdk14
cyclin-dependent kinase 14
chr5_-_5266038 2.313 ENSMUST00000115451.1
ENSMUST00000115452.1
ENSMUST00000131392.1
 Cdk14


cyclin-dependent kinase 14


chr7_-_65370908 2.078 ENSMUST00000032729.6
 Tjp1
tight junction protein 1
chr8_-_31918203 1.981 ENSMUST00000073884.4
 Nrg1
neuregulin 1
chr7_-_65371210 1.908 ENSMUST00000102592.3
 Tjp1
tight junction protein 1
chr13_-_103334429 1.837 ENSMUST00000167058.1
ENSMUST00000164111.1
 Mast4

microtubule associated serine/threonine kinase family member 4

chr2_+_109917639 1.696 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chrX_+_159255919 1.250 ENSMUST00000112492.1
 Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr15_+_76696725 1.199 ENSMUST00000023203.4
 Gpt
glutamic pyruvic transaminase, soluble
chr11_-_106487833 0.831 ENSMUST00000106801.1
 Ern1
endoplasmic reticulum (ER) to nucleus signalling 1
chr11_-_106487796 0.798 ENSMUST00000001059.2
ENSMUST00000106799.1
ENSMUST00000106800.1
 Ern1


endoplasmic reticulum (ER) to nucleus signalling 1


chr8_-_47352348 0.743 ENSMUST00000110367.2
 Stox2
storkhead box 2
chr10_-_80671976 0.730 ENSMUST00000003433.6
 Mknk2
MAP kinase-interacting serine/threonine kinase 2
chrX_+_159255782 0.675 ENSMUST00000126686.1
ENSMUST00000033671.6
 Rps6ka3

ribosomal protein S6 kinase polypeptide 3

chr11_+_98863610 0.648 ENSMUST00000142414.1
ENSMUST00000037480.8
 Wipf2

WAS/WASL interacting protein family, member 2

chr10_-_61452658 0.582 ENSMUST00000167087.1
ENSMUST00000020288.7
 Eif4ebp2

eukaryotic translation initiation factor 4E binding protein 2

chr7_-_126160992 0.363 ENSMUST00000164741.1
 Xpo6
exportin 6
chr11_-_101466222 0.339 ENSMUST00000040430.7
 Vat1
vesicle amine transport protein 1 homolog (T californica)
chr3_-_108402589 0.294 ENSMUST00000147565.1
 Celsr2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr5_+_142401484 0.204 ENSMUST00000072837.5
 Foxk1
forkhead box K1
chr2_-_12301914 0.199 ENSMUST00000028106.4
 Itga8
integrin alpha 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 11.8 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
1.0 3.9 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.6 1.7 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.4 2.0 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.4 3.3 GO:0071493 cellular response to UV-B(GO:0071493) replicative senescence(GO:0090399)
0.4 4.0 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.3 1.6 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.3 2.7 GO:0010587 miRNA catabolic process(GO:0010587)
0.2 4.2 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.2 4.0 GO:0097062 dendritic spine maintenance(GO:0097062)
0.2 3.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 3.9 GO:0071470 cellular response to osmotic stress(GO:0071470)
0.1 7.7 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.1 3.9 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 0.7 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.1 0.3 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.1 0.3 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.0 4.7 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)
0.0 0.6 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.0 1.9 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.0 0.6 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 4.1 GO:0042493 response to drug(GO:0042493)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0070557 PCNA-p21 complex(GO:0070557)
0.9 4.7 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.9 7.7 GO:0030478 actin cap(GO:0030478)
0.5 4.0 GO:0046581 intercellular canaliculus(GO:0046581)
0.3 1.6 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.2 3.9 GO:0032593 insulin-responsive compartment(GO:0032593)
0.2 3.9 GO:0043205 fibril(GO:0043205)
0.1 2.0 GO:0030673 axolemma(GO:0030673)
0.0 4.1 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 2.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 11.8 GO:0005667 transcription factor complex(GO:0005667)
0.0 4.0 GO:0043679 axon terminus(GO:0043679)
0.0 0.2 GO:0032591 dendritic spine membrane(GO:0032591)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.9 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.8 4.2 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.8 5.8 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.8 3.9 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.5 2.0 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.2 3.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.2 3.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 1.7 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 2.7 GO:0035198 miRNA binding(GO:0035198)
0.1 1.6 GO:0016443 bidentate ribonuclease III activity(GO:0016443)
0.1 4.7 GO:0030332 cyclin binding(GO:0030332)
0.1 1.2 GO:0008483 transaminase activity(GO:0008483)
0.0 4.1 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.6 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 1.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 15.7 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 8.4 GO:0003779 actin binding(GO:0003779)
0.0 4.0 GO:0005516 calmodulin binding(GO:0005516)