Motif ID: Twist1

Z-value: 1.343


Transcription factors associated with Twist1:

Gene SymbolEntrez IDGene Name
Twist1 ENSMUSG00000035799.5 Twist1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Twist1mm10_v2_chr12_+_33957645_339576710.152.1e-01Click!


Activity profile for motif Twist1.

activity profile for motif Twist1


Sorted Z-values histogram for motif Twist1

Sorted Z-values for motif Twist1



Network of associatons between targets according to the STRING database.



First level regulatory network of Twist1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_119053339 25.335 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr2_-_172940299 17.667 ENSMUST00000009143.7
 Bmp7
bone morphogenetic protein 7
chr9_+_60794468 17.052 ENSMUST00000050183.6
 Uaca
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr9_+_118478851 14.985 ENSMUST00000150633.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr6_-_95718800 14.527 ENSMUST00000079847.5
 Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr2_-_180225812 13.982 ENSMUST00000015791.5
 Lama5
laminin, alpha 5
chr9_-_54661870 13.531 ENSMUST00000034822.5
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr7_+_45216671 13.369 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr9_-_54661666 11.012 ENSMUST00000128624.1
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr5_+_105519388 10.522 ENSMUST00000067924.6
ENSMUST00000150981.1
 Lrrc8c

leucine rich repeat containing 8 family, member C

chrX_+_100730178 9.508 ENSMUST00000113744.1
 Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr10_-_127341583 9.387 ENSMUST00000026474.3
 Gli1
GLI-Kruppel family member GLI1
chr19_+_25610533 9.185 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr7_+_4119556 8.854 ENSMUST00000079415.5
 Ttyh1
tweety homolog 1 (Drosophila)
chr16_-_18811615 8.783 ENSMUST00000096990.3
 Cdc45
cell division cycle 45
chr7_+_4119525 8.745 ENSMUST00000119661.1
ENSMUST00000129423.1
 Ttyh1

tweety homolog 1 (Drosophila)

chr2_-_137116624 8.421 ENSMUST00000028735.7
 Jag1
jagged 1
chr7_-_127218390 8.111 ENSMUST00000142356.1
ENSMUST00000106314.1
 Sept1

septin 1

chr6_+_83135812 7.413 ENSMUST00000065512.4
 Rtkn
rhotekin
chr7_-_127218303 7.102 ENSMUST00000106313.1
 Sept1
septin 1
chr9_-_44342332 6.580 ENSMUST00000097558.3
 Hmbs
hydroxymethylbilane synthase
chr1_+_74791516 6.500 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr11_-_59290746 6.482 ENSMUST00000010044.7
 Wnt3a
wingless-related MMTV integration site 3A
chr2_-_26122769 6.238 ENSMUST00000140993.1
ENSMUST00000028300.5
 Nacc2

nucleus accumbens associated 2, BEN and BTB (POZ) domain containing

chr19_+_5740885 6.117 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr9_-_114844090 6.097 ENSMUST00000047013.3
 Cmtm8
CKLF-like MARVEL transmembrane domain containing 8
chr15_-_79164477 5.888 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10
chr19_-_3686549 5.613 ENSMUST00000025856.10
ENSMUST00000176867.1
 Lrp5

low density lipoprotein receptor-related protein 5

chr18_+_60911757 5.561 ENSMUST00000040359.5
 Arsi
arylsulfatase i
chr6_+_29398920 5.418 ENSMUST00000181464.1
ENSMUST00000180829.1
 Ccdc136

coiled-coil domain containing 136

chr5_-_62766153 5.389 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr8_+_72135247 5.347 ENSMUST00000003575.9
 Tpm4
tropomyosin 4
chr16_+_37776873 5.281 ENSMUST00000114763.2
 Fstl1
follistatin-like 1
chr5_+_149411749 5.189 ENSMUST00000093110.5
 Medag
mesenteric estrogen dependent adipogenesis
chr8_+_105305572 4.748 ENSMUST00000109375.2
 Elmo3
engulfment and cell motility 3
chr10_-_127030789 4.741 ENSMUST00000120547.1
ENSMUST00000152054.1
 Tsfm

Ts translation elongation factor, mitochondrial

chr10_-_127030813 4.712 ENSMUST00000040560.4
 Tsfm
Ts translation elongation factor, mitochondrial
chr4_-_11386757 4.546 ENSMUST00000108313.1
ENSMUST00000108311.2
 Esrp1

epithelial splicing regulatory protein 1

chr11_-_119355484 4.542 ENSMUST00000100172.2
ENSMUST00000005173.4
 Sgsh

N-sulfoglucosamine sulfohydrolase (sulfamidase)

chr7_+_27486910 4.432 ENSMUST00000008528.7
 Sertad1
SERTA domain containing 1
chr2_+_174110340 4.373 ENSMUST00000044415.9
 Npepl1
aminopeptidase-like 1
chr7_+_127800844 4.088 ENSMUST00000106271.1
ENSMUST00000138432.1
 Hsd3b7

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

chrX_+_71050160 3.806 ENSMUST00000082088.3
ENSMUST00000114629.3
 Mamld1

mastermind-like domain containing 1

chr8_-_71381907 3.791 ENSMUST00000002466.8
 Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr11_+_53770458 3.600 ENSMUST00000138913.1
ENSMUST00000123376.1
ENSMUST00000019043.6
ENSMUST00000133291.1
 Irf1



interferon regulatory factor 1



chr6_-_124813065 3.412 ENSMUST00000149610.2
 Tpi1
triosephosphate isomerase 1
chr11_-_102406783 3.219 ENSMUST00000155104.1
ENSMUST00000130436.1
 Slc25a39

solute carrier family 25, member 39

chr18_-_67724560 3.093 ENSMUST00000120934.1
ENSMUST00000025420.7
ENSMUST00000122412.1
 Ptpn2


protein tyrosine phosphatase, non-receptor type 2


chr9_+_65265173 3.023 ENSMUST00000048762.1
 Cilp
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr17_+_45563928 2.964 ENSMUST00000041353.6
 Slc35b2
solute carrier family 35, member B2
chr15_+_100304782 2.943 ENSMUST00000067752.3
 Mettl7a1
methyltransferase like 7A1
chr2_-_33942111 2.889 ENSMUST00000130988.1
ENSMUST00000127936.1
ENSMUST00000134271.1
 Gm13403


predicted gene 13403


chr8_-_64693027 2.861 ENSMUST00000048967.7
 Cpe
carboxypeptidase E
chr6_+_85187438 2.770 ENSMUST00000045942.8
 Emx1
empty spiracles homeobox 1
chr6_-_90716489 2.696 ENSMUST00000101153.3
 Iqsec1
IQ motif and Sec7 domain 1
chr4_-_57143437 2.629 ENSMUST00000095076.3
ENSMUST00000030142.3
 Epb4.1l4b

erythrocyte protein band 4.1-like 4b

chr7_-_70360593 2.591 ENSMUST00000032768.7
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr11_+_94741782 2.445 ENSMUST00000021240.6
 Cdc34-ps
cell division cycle 34 homolog, pseudogene (S. cerevisiae)
chr19_-_28963863 2.361 ENSMUST00000161813.1
 4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr4_-_130275523 2.322 ENSMUST00000146478.1
 Serinc2
serine incorporator 2
chr7_+_82867327 2.190 ENSMUST00000082237.5
 Mex3b
mex3 homolog B (C. elegans)
chr19_-_24280551 2.171 ENSMUST00000081333.4
 Fxn
frataxin
chr7_-_133123770 2.150 ENSMUST00000164896.1
ENSMUST00000171968.1
 Ctbp2

C-terminal binding protein 2

chr4_-_130275542 2.132 ENSMUST00000154846.1
ENSMUST00000105996.1
 Serinc2

serine incorporator 2

chr15_+_100353149 2.121 ENSMUST00000088142.5
ENSMUST00000176287.1
ENSMUST00000075675.5
 Mettl7a2

AB099516
methyltransferase like 7A2

cDNA sequence AB099516
chr11_+_97663366 1.977 ENSMUST00000044730.5
 Mllt6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr11_+_102189620 1.972 ENSMUST00000070334.3
ENSMUST00000078975.7
 G6pc3

glucose 6 phosphatase, catalytic, 3

chr15_+_100227819 1.970 ENSMUST00000023769.4
 Atf1
activating transcription factor 1
chr7_+_35119285 1.768 ENSMUST00000042985.9
 Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr15_+_100227871 1.715 ENSMUST00000163855.1
 Atf1
activating transcription factor 1
chr8_+_13757663 1.637 ENSMUST00000043962.8
 Cdc16
CDC16 cell division cycle 16
chrX_-_18461371 1.631 ENSMUST00000044188.4
 4930578C19Rik
RIKEN cDNA 4930578C19 gene
chr10_-_75517324 1.621 ENSMUST00000039796.7
 Gucd1
guanylyl cyclase domain containing 1
chr9_+_55150050 1.531 ENSMUST00000122441.1
 Ube2q2
ubiquitin-conjugating enzyme E2Q (putative) 2
chr7_+_44468020 1.508 ENSMUST00000117324.1
ENSMUST00000120852.1
ENSMUST00000118628.1
 Josd2


Josephin domain containing 2


chr3_+_90051630 1.398 ENSMUST00000159064.1
 4933434E20Rik
RIKEN cDNA 4933434E20 gene
chr2_-_142901506 1.339 ENSMUST00000043589.7
 Kif16b
kinesin family member 16B
chr17_+_34039437 1.185 ENSMUST00000131134.1
ENSMUST00000087497.4
ENSMUST00000114255.1
ENSMUST00000114252.1
 Col11a2



collagen, type XI, alpha 2



chr13_-_98891036 1.131 ENSMUST00000109399.2
 Tnpo1
transportin 1
chr7_-_80401707 1.079 ENSMUST00000120753.1
 Furin
furin (paired basic amino acid cleaving enzyme)
chr11_+_72207537 1.051 ENSMUST00000021158.3
 Txndc17
thioredoxin domain containing 17
chr14_-_62761112 0.986 ENSMUST00000053959.6
 Ints6
integrator complex subunit 6
chr1_+_171437535 0.874 ENSMUST00000043839.4
 F11r
F11 receptor
chr9_+_111118070 0.873 ENSMUST00000035078.6
ENSMUST00000098340.2
 Lrrfip2

leucine rich repeat (in FLII) interacting protein 2

chrX_-_104671048 0.857 ENSMUST00000042070.5
 Zdhhc15
zinc finger, DHHC domain containing 15
chr15_-_57892358 0.741 ENSMUST00000022993.5
 Derl1
Der1-like domain family, member 1
chr7_+_44468051 0.667 ENSMUST00000118493.1
 Josd2
Josephin domain containing 2
chr8_+_119910792 0.655 ENSMUST00000108988.2
ENSMUST00000108982.4
ENSMUST00000127664.1
 Usp10

Gm20388
ubiquitin specific peptidase 10

predicted gene 20388
chr18_+_77065195 0.620 ENSMUST00000114777.2
 Pias2
protein inhibitor of activated STAT 2
chr13_-_98890974 0.619 ENSMUST00000179301.1
ENSMUST00000179271.1
 Tnpo1

transportin 1

chr11_-_94549165 0.582 ENSMUST00000040487.3
 Rsad1
radical S-adenosyl methionine domain containing 1
chr11_+_87737530 0.568 ENSMUST00000093955.5
 Supt4a
suppressor of Ty 4A
chr7_+_122289297 0.523 ENSMUST00000064989.5
ENSMUST00000064921.4
 Prkcb

protein kinase C, beta

chr16_+_18426415 0.520 ENSMUST00000115606.1
ENSMUST00000115604.1
ENSMUST00000178093.1
ENSMUST00000177856.1
 Txnrd2



thioredoxin reductase 2



chr11_-_100759942 0.474 ENSMUST00000107363.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr11_-_68927049 0.431 ENSMUST00000038932.7
 Odf4
outer dense fiber of sperm tails 4
chr11_+_76179658 0.424 ENSMUST00000129853.1
ENSMUST00000179223.1
 Fam57a
Fam57a
family with sequence similarity 57, member A
family with sequence similarity 57, member A
chr14_-_50930803 0.421 ENSMUST00000160538.1
ENSMUST00000162957.1
ENSMUST00000161166.1
ENSMUST00000160835.1
ENSMUST00000049312.7
 Tmem55b




transmembrane protein 55b




chr8_-_126475062 0.410 ENSMUST00000170518.1
 Gm17296
predicted gene, 17296
chr7_-_29232478 0.381 ENSMUST00000085818.4
 Kcnk6
potassium inwardly-rectifying channel, subfamily K, member 6
chr6_-_134566913 0.352 ENSMUST00000032322.8
 Lrp6
low density lipoprotein receptor-related protein 6
chr15_+_100334929 0.347 ENSMUST00000075420.4
 Mettl7a3
methyltransferase like 7A3
chr6_-_29165003 0.345 ENSMUST00000007993.9
 Rbm28
RNA binding motif protein 28
chr16_+_62814676 0.261 ENSMUST00000055557.5
 Stx19
syntaxin 19
chr7_+_28180226 0.193 ENSMUST00000172467.1
 Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr6_+_83165920 0.163 ENSMUST00000077407.5
ENSMUST00000113913.1
ENSMUST00000130212.1
 Dctn1


dynactin 1


chr11_+_69935894 0.110 ENSMUST00000149194.1
 Ybx2
Y box protein 2
chr11_+_60104971 0.103 ENSMUST00000064190.6
 Rai1
retinoic acid induced 1
chr11_-_70687917 0.016 ENSMUST00000108545.2
ENSMUST00000120261.1
ENSMUST00000036299.7
ENSMUST00000119120.1
ENSMUST00000100933.3
 Camta2




calmodulin binding transcription activator 2





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
8.7 34.7 GO:0060032 notochord regression(GO:0060032)
6.1 6.1 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
5.9 17.7 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
5.0 15.0 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
3.8 15.2 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
2.9 8.8 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
2.2 6.5 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) negative regulation of dopaminergic neuron differentiation(GO:1904339) regulation of cardiac cell fate specification(GO:2000043)
1.9 9.5 GO:0070125 mitochondrial translational elongation(GO:0070125)
1.9 5.6 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
1.7 15.7 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
1.7 8.4 GO:0072015 ciliary body morphogenesis(GO:0061073) glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
1.6 14.5 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
1.2 3.6 GO:2000564 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
1.1 3.4 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
1.0 3.1 GO:0038145 interleukin-4-mediated signaling pathway(GO:0035771) macrophage colony-stimulating factor signaling pathway(GO:0038145) tyrosine phosphorylation of Stat6 protein(GO:0042505) regulation of tyrosine phosphorylation of Stat6 protein(GO:0042525) regulation of interleukin-6-mediated signaling pathway(GO:0070103) negative regulation of interleukin-6-mediated signaling pathway(GO:0070104)
1.0 2.9 GO:0030070 insulin processing(GO:0030070)
1.0 9.5 GO:0090527 actin filament reorganization(GO:0090527)
0.9 17.1 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.7 13.4 GO:0030903 notochord development(GO:0030903)
0.7 24.5 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.7 6.6 GO:0018065 protein-cofactor linkage(GO:0018065)
0.7 2.0 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.6 4.5 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.6 6.2 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.5 2.2 GO:0072697 protein localization to cell cortex(GO:0072697)
0.5 18.5 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.5 2.6 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.5 3.0 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.5 5.9 GO:0032808 lacrimal gland development(GO:0032808)
0.4 2.2 GO:0019230 protein autoprocessing(GO:0016540) proprioception(GO:0019230)
0.4 3.0 GO:0051503 adenine nucleotide transport(GO:0051503)
0.4 4.1 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.4 1.2 GO:0060023 soft palate development(GO:0060023)
0.4 3.8 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.4 0.4 GO:0061349 planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354)
0.3 2.8 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.3 12.7 GO:1902476 chloride transmembrane transport(GO:1902476)
0.2 3.9 GO:0050872 white fat cell differentiation(GO:0050872)
0.2 0.9 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.2 1.1 GO:0032911 nerve growth factor production(GO:0032902) negative regulation of transforming growth factor beta1 production(GO:0032911)
0.2 1.7 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 4.5 GO:0030201 heparan sulfate proteoglycan metabolic process(GO:0030201)
0.1 2.7 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 3.2 GO:0006783 heme biosynthetic process(GO:0006783)
0.1 1.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 0.5 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.1 0.9 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 0.4 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.1 0.6 GO:0033014 porphyrin-containing compound biosynthetic process(GO:0006779) tetrapyrrole biosynthetic process(GO:0033014)
0.1 11.3 GO:0045444 fat cell differentiation(GO:0045444)
0.1 0.9 GO:0016188 synaptic vesicle maturation(GO:0016188)
0.1 0.6 GO:0060766 negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0 1.6 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.6 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 1.0 GO:0016180 snRNA processing(GO:0016180)
0.0 3.7 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.0 3.5 GO:0042594 response to starvation(GO:0042594)
0.0 4.7 GO:0006909 phagocytosis(GO:0006909)
0.0 1.1 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 4.4 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 0.7 GO:0031648 protein destabilization(GO:0031648)
0.0 2.5 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.3 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 0.4 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.4 GO:0030488 tRNA methylation(GO:0030488)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 17.6 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
4.3 17.1 GO:0043293 apoptosome(GO:0043293)
3.5 14.0 GO:0043259 laminin-10 complex(GO:0043259)
2.9 8.8 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
2.7 34.7 GO:0097542 ciliary tip(GO:0097542)
2.4 14.5 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
2.3 6.8 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
1.7 15.2 GO:0072687 meiotic spindle(GO:0072687)
0.9 3.7 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.7 5.9 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.6 1.8 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.2 6.2 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2 5.3 GO:0002102 podosome(GO:0002102)
0.2 2.9 GO:0031045 dense core granule(GO:0031045)
0.2 0.9 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 24.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 2.2 GO:0097470 ribbon synapse(GO:0097470)
0.1 1.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 28.8 GO:0031012 extracellular matrix(GO:0031012)
0.1 1.0 GO:0032039 integrator complex(GO:0032039)
0.1 1.1 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 8.6 GO:0005884 actin filament(GO:0005884)
0.1 1.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 0.4 GO:0001520 outer dense fiber(GO:0001520)
0.1 3.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 0.7 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 3.1 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 6.6 GO:0000793 condensed chromosome(GO:0000793)
0.0 11.3 GO:0005667 transcription factor complex(GO:0005667)
0.0 4.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 2.0 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.2 GO:0030904 retromer complex(GO:0030904)
0.0 0.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 1.2 GO:0034399 nuclear periphery(GO:0034399)
0.0 0.5 GO:0031526 brush border membrane(GO:0031526)
0.0 10.2 GO:0005615 extracellular space(GO:0005615)
0.0 3.6 GO:0000790 nuclear chromatin(GO:0000790)
0.0 2.0 GO:0005769 early endosome(GO:0005769)
0.0 0.4 GO:0031902 late endosome membrane(GO:0031902)
0.0 2.1 GO:0016324 apical plasma membrane(GO:0016324)
0.0 15.3 GO:0005783 endoplasmic reticulum(GO:0005783)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 17.6 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
2.4 14.5 GO:0034943 acyl-CoA ligase activity(GO:0003996) 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
2.2 24.5 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
2.2 6.5 GO:0005110 frizzled-2 binding(GO:0005110)
1.8 17.7 GO:0070700 BMP receptor binding(GO:0070700)
1.3 10.5 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
1.1 8.8 GO:0003688 DNA replication origin binding(GO:0003688)
1.1 6.6 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
1.0 3.0 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
1.0 9.5 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.7 7.4 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.7 10.1 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.7 4.1 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.4 3.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.4 2.2 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.3 6.0 GO:0015026 coreceptor activity(GO:0015026)
0.3 9.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.3 4.5 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.3 3.4 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.3 2.6 GO:0001972 retinoic acid binding(GO:0001972)
0.3 34.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.3 8.4 GO:0005112 Notch binding(GO:0005112)
0.3 6.1 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.3 15.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 2.9 GO:0004185 serine-type carboxypeptidase activity(GO:0004185) cobalt ion binding(GO:0050897)
0.2 2.0 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.2 1.6 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.2 6.5 GO:0005109 frizzled binding(GO:0005109)
0.2 6.2 GO:0004407 histone deacetylase activity(GO:0004407)
0.1 0.4 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.1 6.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 14.0 GO:0005178 integrin binding(GO:0005178)
0.1 1.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 4.4 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 2.2 GO:0008242 omega peptidase activity(GO:0008242)
0.1 2.2 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 3.8 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 29.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 0.6 GO:0034916 4-methyloctanoyl-CoA dehydrogenase activity(GO:0034580) naphthyl-2-methyl-succinyl-CoA dehydrogenase activity(GO:0034845) 2-methylhexanoyl-CoA dehydrogenase activity(GO:0034916) propionyl-CoA dehydrogenase activity(GO:0043820) thiol-driven fumarate reductase activity(GO:0043830) coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity(GO:0052758) coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity(GO:0052759) coenzyme F420-dependent 2,4-dinitrophenol reductase activity(GO:0052760)
0.1 0.6 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 2.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 6.1 GO:0005125 cytokine activity(GO:0005125)
0.1 0.5 GO:0035184 histone threonine kinase activity(GO:0035184)
0.1 0.7 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 1.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 9.2 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.1 5.3 GO:0008201 heparin binding(GO:0008201)
0.0 1.1 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.0 15.2 GO:0005525 GTP binding(GO:0005525)
0.0 1.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.4 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.9 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 1.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 4.1 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
0.0 3.5 GO:0003729 mRNA binding(GO:0003729)
0.0 3.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.7 GO:0002039 p53 binding(GO:0002039)