Motif ID: Twist1

Z-value: 1.343


Transcription factors associated with Twist1:

Gene SymbolEntrez IDGene Name
Twist1 ENSMUSG00000035799.5 Twist1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Twist1mm10_v2_chr12_+_33957645_339576710.152.1e-01Click!


Activity profile for motif Twist1.

activity profile for motif Twist1


Sorted Z-values histogram for motif Twist1

Sorted Z-values for motif Twist1



Network of associatons between targets according to the STRING database.



First level regulatory network of Twist1

PNG image of the network

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Top targets:


Showing 1 to 20 of 109 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_119053339 25.335 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr2_-_172940299 17.667 ENSMUST00000009143.7
 Bmp7
bone morphogenetic protein 7
chr9_+_60794468 17.052 ENSMUST00000050183.6
 Uaca
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr9_+_118478851 14.985 ENSMUST00000150633.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr6_-_95718800 14.527 ENSMUST00000079847.5
 Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr2_-_180225812 13.982 ENSMUST00000015791.5
 Lama5
laminin, alpha 5
chr9_-_54661870 13.531 ENSMUST00000034822.5
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr7_+_45216671 13.369 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr9_-_54661666 11.012 ENSMUST00000128624.1
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr5_+_105519388 10.522 ENSMUST00000067924.6
ENSMUST00000150981.1
 Lrrc8c

leucine rich repeat containing 8 family, member C

chrX_+_100730178 9.508 ENSMUST00000113744.1
 Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr10_-_127341583 9.387 ENSMUST00000026474.3
 Gli1
GLI-Kruppel family member GLI1
chr19_+_25610533 9.185 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr7_+_4119556 8.854 ENSMUST00000079415.5
 Ttyh1
tweety homolog 1 (Drosophila)
chr16_-_18811615 8.783 ENSMUST00000096990.3
 Cdc45
cell division cycle 45
chr7_+_4119525 8.745 ENSMUST00000119661.1
ENSMUST00000129423.1
 Ttyh1

tweety homolog 1 (Drosophila)

chr2_-_137116624 8.421 ENSMUST00000028735.7
 Jag1
jagged 1
chr7_-_127218390 8.111 ENSMUST00000142356.1
ENSMUST00000106314.1
 Sept1

septin 1

chr6_+_83135812 7.413 ENSMUST00000065512.4
 Rtkn
rhotekin
chr7_-_127218303 7.102 ENSMUST00000106313.1
 Sept1
septin 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.7 34.7 GO:0060032 notochord regression(GO:0060032)
0.7 24.5 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.5 18.5 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
5.9 17.7 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.9 17.1 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
1.7 15.7 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
3.8 15.2 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
5.0 15.0 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.6 14.5 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.7 13.4 GO:0030903 notochord development(GO:0030903)
0.3 12.7 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 11.3 GO:0045444 fat cell differentiation(GO:0045444)
1.9 9.5 GO:0070125 mitochondrial translational elongation(GO:0070125)
1.0 9.5 GO:0090527 actin filament reorganization(GO:0090527)
2.9 8.8 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
1.7 8.4 GO:0072015 ciliary body morphogenesis(GO:0061073) glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.7 6.6 GO:0018065 protein-cofactor linkage(GO:0018065)
2.2 6.5 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) negative regulation of dopaminergic neuron differentiation(GO:1904339) regulation of cardiac cell fate specification(GO:2000043)
0.6 6.2 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
6.1 6.1 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 34.7 GO:0097542 ciliary tip(GO:0097542)
0.1 28.8 GO:0031012 extracellular matrix(GO:0031012)
0.1 24.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
5.9 17.6 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
4.3 17.1 GO:0043293 apoptosome(GO:0043293)
0.0 15.3 GO:0005783 endoplasmic reticulum(GO:0005783)
1.7 15.2 GO:0072687 meiotic spindle(GO:0072687)
2.4 14.5 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
3.5 14.0 GO:0043259 laminin-10 complex(GO:0043259)
0.0 11.3 GO:0005667 transcription factor complex(GO:0005667)
0.0 10.2 GO:0005615 extracellular space(GO:0005615)
2.9 8.8 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 8.6 GO:0005884 actin filament(GO:0005884)
2.3 6.8 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 6.6 GO:0000793 condensed chromosome(GO:0000793)
0.2 6.2 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.7 5.9 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.2 5.3 GO:0002102 podosome(GO:0002102)
0.0 4.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.9 3.7 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 34.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 29.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
2.2 24.5 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
1.8 17.7 GO:0070700 BMP receptor binding(GO:0070700)
4.4 17.6 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 15.2 GO:0005525 GTP binding(GO:0005525)
0.3 15.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
2.4 14.5 GO:0034943 acyl-CoA ligase activity(GO:0003996) 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
0.1 14.0 GO:0005178 integrin binding(GO:0005178)
1.3 10.5 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.7 10.1 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
1.0 9.5 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.3 9.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 9.2 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
1.1 8.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.3 8.4 GO:0005112 Notch binding(GO:0005112)
0.7 7.4 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 6.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
1.1 6.6 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
2.2 6.5 GO:0005110 frizzled-2 binding(GO:0005110)