Motif ID: Vsx1_Uncx_Prrx2_Shox2_Noto

Z-value: 1.317

Transcription factors associated with Vsx1_Uncx_Prrx2_Shox2_Noto:

Gene SymbolEntrez IDGene Name
Noto ENSMUSG00000068302.7 Noto
Prrx2 ENSMUSG00000039476.7 Prrx2
Shox2 ENSMUSG00000027833.10 Shox2
Uncx ENSMUSG00000029546.11 Uncx
Vsx1 ENSMUSG00000033080.8 Vsx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prrx2mm10_v2_chr2_+_30834972_308349720.692.5e-11Click!
Shox2mm10_v2_chr3_-_66981279_669813180.532.0e-06Click!
Uncxmm10_v2_chr5_+_139543889_1395439040.532.1e-06Click!


Activity profile for motif Vsx1_Uncx_Prrx2_Shox2_Noto.

activity profile for motif Vsx1_Uncx_Prrx2_Shox2_Noto


Sorted Z-values histogram for motif Vsx1_Uncx_Prrx2_Shox2_Noto

Sorted Z-values for motif Vsx1_Uncx_Prrx2_Shox2_Noto



Network of associatons between targets according to the STRING database.



First level regulatory network of Vsx1_Uncx_Prrx2_Shox2_Noto

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48665098 47.468 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr2_+_20737306 40.955 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr8_-_61902669 37.318 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr3_+_159839729 35.119 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr14_-_118052235 33.211 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr5_+_139543889 31.729 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr9_+_118478344 27.487 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr2_+_71528657 26.461 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr2_-_168767136 26.040 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr2_-_168767029 24.106 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr7_-_49636847 22.964 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr17_+_34592248 22.878 ENSMUST00000038149.6
 Pbx2
pre B cell leukemia homeobox 2
chr2_+_25372315 22.661 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
 Sapcd2


suppressor APC domain containing 2


chrX_-_60893430 22.102 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr13_-_53473074 22.094 ENSMUST00000021922.8
 Msx2
msh homeobox 2
chr9_+_118478182 21.943 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr3_-_88410295 19.799 ENSMUST00000056370.7
 Pmf1
polyamine-modulated factor 1
chr15_+_25773985 19.779 ENSMUST00000125667.1
 Myo10
myosin X
chr4_-_97778042 17.771 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr7_-_37773555 16.834 ENSMUST00000176534.1
 Zfp536
zinc finger protein 536

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 160 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 64.5 GO:0007638 mechanosensory behavior(GO:0007638)
13.0 52.0 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
2.8 50.1 GO:0001833 inner cell mass cell proliferation(GO:0001833)
16.5 49.4 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.4 40.7 GO:0048706 embryonic skeletal system development(GO:0048706)
2.5 37.3 GO:0071803 positive regulation of podosome assembly(GO:0071803)
2.7 35.1 GO:0031017 exocrine pancreas development(GO:0031017)
5.5 33.2 GO:0006570 tyrosine metabolic process(GO:0006570)
2.0 32.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
4.0 31.7 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
8.8 26.5 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
2.1 23.0 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
7.4 22.1 GO:0048818 embryonic nail plate morphogenesis(GO:0035880) positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
1.4 22.1 GO:0007530 sex determination(GO:0007530)
6.4 19.3 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 19.2 GO:0008360 regulation of cell shape(GO:0008360)
0.7 17.2 GO:0009954 proximal/distal pattern formation(GO:0009954)
1.9 16.7 GO:0010587 miRNA catabolic process(GO:0010587)
3.2 15.9 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.6 14.7 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 220.4 GO:0005634 nucleus(GO:0005634)
0.2 66.1 GO:0005667 transcription factor complex(GO:0005667)
0.4 49.7 GO:0000792 heterochromatin(GO:0000792)
1.5 37.3 GO:0002102 podosome(GO:0002102)
1.1 35.1 GO:0032839 dendrite cytoplasm(GO:0032839)
1.3 33.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 22.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
3.3 19.8 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.4 19.8 GO:0016459 myosin complex(GO:0016459)
0.1 14.6 GO:0030427 site of polarized growth(GO:0030427)
0.1 12.6 GO:0016607 nuclear speck(GO:0016607)
2.0 11.8 GO:0001674 female germ cell nucleus(GO:0001674)
0.3 11.0 GO:0032809 neuronal cell body membrane(GO:0032809)
1.0 10.5 GO:0005915 zonula adherens(GO:0005915)
0.1 10.0 GO:0005925 focal adhesion(GO:0005925)
0.1 9.0 GO:0043198 dendritic shaft(GO:0043198)
1.7 8.6 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 8.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.5 8.0 GO:0005614 interstitial matrix(GO:0005614)
1.0 7.9 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 190.9 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.4 126.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 54.5 GO:0003779 actin binding(GO:0003779)
0.8 48.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
4.2 41.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
2.5 37.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
2.4 33.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.3 32.9 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.1 23.4 GO:0000287 magnesium ion binding(GO:0000287)
0.7 22.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.5 22.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
1.5 19.8 GO:0043522 leucine zipper domain binding(GO:0043522)
2.4 19.3 GO:0050693 LBD domain binding(GO:0050693)
1.1 18.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 17.5 GO:0044822 poly(A) RNA binding(GO:0044822)
2.3 15.9 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.3 15.7 GO:0030507 spectrin binding(GO:0030507)
0.6 13.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.4 13.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.6 13.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)