Motif ID: Vsx2_Dlx3

Z-value: 1.038

Transcription factors associated with Vsx2_Dlx3:

Gene SymbolEntrez IDGene Name
Dlx3 ENSMUSG00000001510.7 Dlx3
Vsx2 ENSMUSG00000021239.6 Vsx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Vsx2mm10_v2_chr12_+_84569762_845698400.262.8e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Vsx2_Dlx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 125 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 53.636 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr6_-_23248264 38.782 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr2_-_168767136 18.369 ENSMUST00000029061.5
ENSMUST00000103074.1
Sall4

sal-like 4 (Drosophila)

chr2_-_168767029 12.696 ENSMUST00000075044.3
Sall4
sal-like 4 (Drosophila)
chr3_-_154328634 10.256 ENSMUST00000167744.1
Lhx8
LIM homeobox protein 8
chr3_+_159839729 10.105 ENSMUST00000068952.5
Wls
wntless homolog (Drosophila)
chr17_-_70853482 8.782 ENSMUST00000118283.1
Tgif1
TGFB-induced factor homeobox 1
chr7_-_49636847 8.054 ENSMUST00000032717.6
Dbx1
developing brain homeobox 1
chr12_-_56535047 7.265 ENSMUST00000178477.2
Nkx2-1
NK2 homeobox 1
chr14_-_48662740 7.183 ENSMUST00000122009.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr9_-_79977782 6.539 ENSMUST00000093811.4
Filip1
filamin A interacting protein 1
chr4_+_8690399 5.851 ENSMUST00000127476.1
Chd7
chromodomain helicase DNA binding protein 7
chr3_+_55782500 5.679 ENSMUST00000075422.4
Mab21l1
mab-21-like 1 (C. elegans)
chrX_-_60893430 5.321 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr5_-_98566762 4.963 ENSMUST00000086912.4
1700010H22Rik
RIKEN cDNA 1700010H22 gene
chr3_-_116253467 4.879 ENSMUST00000090473.5
Gpr88
G-protein coupled receptor 88
chr4_+_62583568 4.717 ENSMUST00000098031.3
Rgs3
regulator of G-protein signaling 3
chr3_-_79841729 4.653 ENSMUST00000168038.1
Tmem144
transmembrane protein 144
chr8_-_61902669 4.612 ENSMUST00000121785.1
ENSMUST00000034057.7
Palld

palladin, cytoskeletal associated protein

chr17_+_43952999 4.534 ENSMUST00000177857.1
Rcan2
regulator of calcineurin 2

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.7 53.6 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
6.9 41.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.7 31.1 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.8 10.1 GO:0031017 exocrine pancreas development(GO:0031017)
0.3 9.8 GO:0007638 mechanosensory behavior(GO:0007638)
0.6 9.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 9.2 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.4 8.1 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
2.4 7.3 GO:0021759 globus pallidus development(GO:0021759)
1.8 7.2 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.6 6.8 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
2.0 5.9 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.4 5.3 GO:0007530 sex determination(GO:0007530)
0.7 5.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 5.0 GO:0043010 camera-type eye development(GO:0043010)
0.1 4.9 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.3 4.6 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.2 4.4 GO:0009409 response to cold(GO:0009409)
0.3 4.3 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.2 4.0 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 127.4 GO:0005634 nucleus(GO:0005634)
0.2 31.1 GO:0000792 heterochromatin(GO:0000792)
1.7 10.3 GO:0001674 female germ cell nucleus(GO:0001674)
0.3 10.1 GO:0032590 dendrite membrane(GO:0032590)
0.0 9.9 GO:0005667 transcription factor complex(GO:0005667)
0.2 4.6 GO:0002102 podosome(GO:0002102)
0.7 4.0 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.3 3.4 GO:0061700 GATOR2 complex(GO:0061700)
0.1 3.3 GO:0016459 myosin complex(GO:0016459)
0.2 2.7 GO:0016460 myosin II complex(GO:0016460)
0.1 2.6 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.4 2.2 GO:0061689 paranodal junction(GO:0033010) tricellular tight junction(GO:0061689)
0.5 2.0 GO:0060187 cell pole(GO:0060187)
0.5 1.9 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.3 1.9 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 1.8 GO:1990391 DNA repair complex(GO:1990391)
0.0 1.7 GO:0005871 kinesin complex(GO:0005871)
0.0 1.7 GO:0070469 respiratory chain(GO:0070469)
0.0 1.5 GO:0032420 stereocilium(GO:0032420)
0.0 1.4 GO:0030131 clathrin adaptor complex(GO:0030131)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 131.1 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.2 34.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
1.0 10.1 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.4 8.8 GO:0070410 co-SMAD binding(GO:0070410)
0.6 7.3 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.3 5.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 5.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 5.0 GO:0003774 motor activity(GO:0003774)
0.7 4.3 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 4.2 GO:0003779 actin binding(GO:0003779)
0.0 4.1 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.7 4.0 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.3 4.0 GO:0043522 leucine zipper domain binding(GO:0043522)
0.6 3.4 GO:0070728 leucine binding(GO:0070728)
0.2 3.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.3 3.2 GO:0070700 BMP receptor binding(GO:0070700)
0.0 3.1 GO:0000287 magnesium ion binding(GO:0000287)
0.0 2.7 GO:0035254 glutamate receptor binding(GO:0035254)
0.3 2.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.2 1.9 GO:0031995 insulin-like growth factor II binding(GO:0031995)