Motif ID: Ybx1_Nfya_Nfyb_Nfyc_Cebpz

Z-value: 7.398

Transcription factors associated with Ybx1_Nfya_Nfyb_Nfyc_Cebpz:

Gene SymbolEntrez IDGene Name
Cebpz ENSMUSG00000024081.8 Cebpz
Nfya ENSMUSG00000023994.7 Nfya
Nfyb ENSMUSG00000020248.12 Nfyb
Nfyc ENSMUSG00000032897.11 Nfyc
Ybx1 ENSMUSG00000028639.8 Ybx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfybmm10_v2_chr10_-_82764088_82764144-0.501.2e-05Click!
Nfycmm10_v2_chr4_-_120815703_1208157610.432.2e-04Click!
Cebpzmm10_v2_chr17_-_78937031_78937074-0.413.8e-04Click!
Ybx1mm10_v2_chr4_-_119294520_1192946040.414.7e-04Click!
Nfyamm10_v2_chr17_-_48409729_48409906-0.272.5e-02Click!


Activity profile for motif Ybx1_Nfya_Nfyb_Nfyc_Cebpz.

activity profile for motif Ybx1_Nfya_Nfyb_Nfyc_Cebpz


Sorted Z-values histogram for motif Ybx1_Nfya_Nfyb_Nfyc_Cebpz

Sorted Z-values for motif Ybx1_Nfya_Nfyb_Nfyc_Cebpz



Network of associatons between targets according to the STRING database.



First level regulatory network of Ybx1_Nfya_Nfyb_Nfyc_Cebpz

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_124829582 130.423 ENSMUST00000024270.7
 Cdca3
cell division cycle associated 3
chr8_+_83955507 127.882 ENSMUST00000005607.8
 Asf1b
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr11_-_99024179 121.666 ENSMUST00000068031.7
 Top2a
topoisomerase (DNA) II alpha
chr11_-_87108656 104.022 ENSMUST00000051395.8
 Prr11
proline rich 11
chr14_+_46760526 103.013 ENSMUST00000067426.4
 Cdkn3
cyclin-dependent kinase inhibitor 3
chr8_+_57511833 101.463 ENSMUST00000067925.6
 Hmgb2
high mobility group box 2
chr3_-_27153844 95.237 ENSMUST00000176242.2
ENSMUST00000176780.1
 Ect2

ect2 oncogene

chr3_-_27153861 94.971 ENSMUST00000108300.1
ENSMUST00000108298.2
 Ect2

ect2 oncogene

chr3_-_27153782 92.267 ENSMUST00000175857.1
ENSMUST00000177055.1
ENSMUST00000176535.1
 Ect2


ect2 oncogene


chr6_+_124829540 90.712 ENSMUST00000150120.1
 Cdca3
cell division cycle associated 3
chr14_-_67715585 88.059 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2


chr1_+_139454747 87.648 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr6_+_124830217 86.811 ENSMUST00000131847.1
ENSMUST00000151674.1
 Cdca3

cell division cycle associated 3

chr7_-_48881596 75.155 ENSMUST00000119223.1
 E2f8
E2F transcription factor 8
chr15_+_99074968 75.128 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr13_+_51645232 69.080 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chr2_+_164769892 68.878 ENSMUST00000088248.6
ENSMUST00000001439.6
 Ube2c

ubiquitin-conjugating enzyme E2C

chr17_-_24251382 67.877 ENSMUST00000115390.3
 Ccnf
cyclin F
chr9_-_70421533 67.317 ENSMUST00000034742.6
 Ccnb2
cyclin B2
chr16_+_14163275 65.781 ENSMUST00000023359.6
ENSMUST00000117958.1
 Nde1

nuclear distribution gene E homolog 1 (A nidulans)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 616 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 782.2 GO:0007067 mitotic nuclear division(GO:0007067)
19.8 336.9 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
25.4 304.5 GO:0007100 mitotic centrosome separation(GO:0007100)
7.7 239.2 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
6.0 174.3 GO:0006270 DNA replication initiation(GO:0006270)
7.2 172.7 GO:0051310 metaphase plate congression(GO:0051310)
13.0 156.3 GO:0022027 interkinetic nuclear migration(GO:0022027)
24.5 146.9 GO:0009786 regulation of asymmetric cell division(GO:0009786)
8.5 144.1 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
44.2 132.5 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
18.8 131.7 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
3.5 124.9 GO:0008156 negative regulation of DNA replication(GO:0008156)
9.6 124.5 GO:0071459 protein localization to chromosome, centromeric region(GO:0071459)
30.4 121.7 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
8.4 109.0 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
8.9 106.5 GO:0007076 mitotic chromosome condensation(GO:0007076)
15.0 105.0 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
25.2 100.6 GO:0098763 mitotic cell cycle phase(GO:0098763)
15.1 90.5 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
7.2 86.6 GO:0019985 translesion synthesis(GO:0019985)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 251 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 763.1 GO:0005634 nucleus(GO:0005634)
1.2 475.3 GO:0005667 transcription factor complex(GO:0005667)
3.9 366.6 GO:0000793 condensed chromosome(GO:0000793)
62.8 313.8 GO:0097149 centralspindlin complex(GO:0097149)
16.6 215.8 GO:0031616 spindle pole centrosome(GO:0031616)
2.2 183.2 GO:0000776 kinetochore(GO:0000776)
4.6 182.6 GO:0005876 spindle microtubule(GO:0005876)
36.4 182.1 GO:0032133 chromosome passenger complex(GO:0032133)
4.0 173.0 GO:0005657 replication fork(GO:0005657)
1.9 171.2 GO:0005814 centriole(GO:0005814)
18.6 149.0 GO:0005818 aster(GO:0005818)
2.9 144.7 GO:0005871 kinesin complex(GO:0005871)
5.2 133.9 GO:0005680 anaphase-promoting complex(GO:0005680)
30.9 123.6 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
1.7 116.4 GO:0005643 nuclear pore(GO:0005643)
0.8 104.8 GO:0005813 centrosome(GO:0005813)
7.7 100.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
19.0 94.8 GO:0031262 Ndc80 complex(GO:0031262)
5.9 88.6 GO:0042555 MCM complex(GO:0042555)
17.5 87.6 GO:0036449 microtubule minus-end(GO:0036449)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 380 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 294.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
2.2 266.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.3 211.3 GO:0042393 histone binding(GO:0042393)
1.0 197.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
1.0 177.5 GO:0008017 microtubule binding(GO:0008017)
3.3 160.8 GO:0003777 microtubule motor activity(GO:0003777)
1.2 148.2 GO:0001047 core promoter binding(GO:0001047)
0.6 143.6 GO:0003682 chromatin binding(GO:0003682)
3.4 142.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
2.1 137.7 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
3.9 128.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
2.1 122.1 GO:0003684 damaged DNA binding(GO:0003684)
10.0 120.4 GO:0035173 histone kinase activity(GO:0035173)
19.7 118.3 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
18.4 110.6 GO:0010997 anaphase-promoting complex binding(GO:0010997)
2.4 110.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
36.3 109.0 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
17.1 102.9 GO:0050786 RAGE receptor binding(GO:0050786)
12.7 101.5 GO:0003688 DNA replication origin binding(GO:0003688)
3.4 97.5 GO:0008139 nuclear localization sequence binding(GO:0008139)