Motif ID: Zbtb12

Z-value: 0.698


Transcription factors associated with Zbtb12:

Gene SymbolEntrez IDGene Name
Zbtb12 ENSMUSG00000049823.8 Zbtb12

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb12mm10_v2_chr17_+_34894515_34894573-0.423.5e-04Click!


Activity profile for motif Zbtb12.

activity profile for motif Zbtb12


Sorted Z-values histogram for motif Zbtb12

Sorted Z-values for motif Zbtb12



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb12

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_12027958 11.752 ENSMUST00000109654.1
 Grb10
growth factor receptor bound protein 10
chr14_-_103844173 9.839 ENSMUST00000022718.3
 Ednrb
endothelin receptor type B
chr9_+_37367354 8.191 ENSMUST00000051839.7
 Hepacam
hepatocyte cell adhesion molecule
chr3_+_88081997 8.189 ENSMUST00000071812.5
 Iqgap3
IQ motif containing GTPase activating protein 3
chr6_-_124814288 6.869 ENSMUST00000172132.2
 Tpi1
triosephosphate isomerase 1
chr19_+_59260878 6.311 ENSMUST00000026084.3
 Slc18a2
solute carrier family 18 (vesicular monoamine), member 2
chr3_-_84155762 6.093 ENSMUST00000047368.6
 Mnd1
meiotic nuclear divisions 1 homolog (S. cerevisiae)
chr4_-_151057933 5.730 ENSMUST00000030797.3
 Vamp3
vesicle-associated membrane protein 3
chr13_+_104229366 5.709 ENSMUST00000022227.6
 Cenpk
centromere protein K
chr17_-_15375969 5.382 ENSMUST00000014917.7
 Dll1
delta-like 1 (Drosophila)
chr17_-_27029009 5.234 ENSMUST00000078691.5
 Bak1
BCL2-antagonist/killer 1
chr11_+_54902743 5.009 ENSMUST00000082430.3
 Gpx3
glutathione peroxidase 3
chr11_-_88718078 4.872 ENSMUST00000092794.5
 Msi2
musashi RNA-binding protein 2
chr11_+_54902917 4.737 ENSMUST00000149324.1
 Gpx3
glutathione peroxidase 3
chr6_+_90462562 4.397 ENSMUST00000032174.5
 Klf15
Kruppel-like factor 15
chr18_-_70472429 4.191 ENSMUST00000067556.3
 4930503L19Rik
RIKEN cDNA 4930503L19 gene
chr8_-_45382198 3.287 ENSMUST00000093526.6
 Fam149a
family with sequence similarity 149, member A
chr4_+_32983417 3.015 ENSMUST00000084747.5
 Rragd
Ras-related GTP binding D
chr19_-_10240689 2.967 ENSMUST00000088013.5
 Myrf
myelin regulatory factor
chr5_+_92603039 2.915 ENSMUST00000050952.3
 Stbd1
starch binding domain 1
chr2_-_28916668 2.457 ENSMUST00000113847.1
 Barhl1
BarH-like 1 (Drosophila)
chr15_-_88954400 2.443 ENSMUST00000109371.1
 Ttll8
tubulin tyrosine ligase-like family, member 8
chr14_+_79481164 2.388 ENSMUST00000040131.5
 Elf1
E74-like factor 1
chr7_+_92875253 2.268 ENSMUST00000076052.6
 Prcp
prolylcarboxypeptidase (angiotensinase C)
chr7_-_127993831 2.059 ENSMUST00000033056.3
 Pycard
PYD and CARD domain containing
chr9_+_22411515 1.931 ENSMUST00000058868.7
 9530077C05Rik
RIKEN cDNA 9530077C05 gene
chr1_+_69826986 1.905 ENSMUST00000065425.5
ENSMUST00000113940.2
 Spag16

sperm associated antigen 16

chr15_+_82341179 1.745 ENSMUST00000050349.2
 Fam109b
family with sequence similarity 109, member B
chr2_+_31759993 1.459 ENSMUST00000124089.1
 Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
chr16_-_33967032 1.437 ENSMUST00000023510.6
 Umps
uridine monophosphate synthetase
chr2_+_31759932 1.417 ENSMUST00000028190.6
 Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
chr5_+_95956916 1.004 ENSMUST00000023840.5
 Cxcl13
chemokine (C-X-C motif) ligand 13
chr3_+_5218589 0.809 ENSMUST00000177488.1
 Zfhx4
zinc finger homeodomain 4
chr4_-_119173849 0.781 ENSMUST00000052715.4
ENSMUST00000179290.1
ENSMUST00000154226.1
 Zfp691


zinc finger protein 691


chr10_-_86011833 0.778 ENSMUST00000105304.1
ENSMUST00000061699.5
 Bpifc

BPI fold containing family C

chr3_+_5218546 0.752 ENSMUST00000026284.6
 Zfhx4
zinc finger homeodomain 4
chr6_+_29398920 0.739 ENSMUST00000181464.1
ENSMUST00000180829.1
 Ccdc136

coiled-coil domain containing 136

chr9_+_57827284 0.614 ENSMUST00000163186.1
 Gm17231
predicted gene 17231
chrX_-_140956675 0.613 ENSMUST00000033805.8
ENSMUST00000112978.1
 Psmd10

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

chr17_-_27909206 0.597 ENSMUST00000114848.1
 Taf11
TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr4_-_149909719 0.547 ENSMUST00000105685.1
 Spsb1
splA/ryanodine receptor domain and SOCS box containing 1
chr5_+_67260696 0.488 ENSMUST00000161233.1
ENSMUST00000160352.1
 Tmem33

transmembrane protein 33

chr3_+_5218516 0.470 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr17_-_56874421 0.461 ENSMUST00000043062.4
 Acsbg2
acyl-CoA synthetase bubblegum family member 2
chr11_-_100441795 0.460 ENSMUST00000107398.1
 Nt5c3b
5'-nucleotidase, cytosolic IIIB
chr5_-_35679416 0.442 ENSMUST00000114233.2
 Htra3
HtrA serine peptidase 3
chr17_+_27909337 0.434 ENSMUST00000114842.1
ENSMUST00000025058.7
ENSMUST00000088027.5
 Anks1


ankyrin repeat and SAM domain containing 1


chr12_+_105784694 0.369 ENSMUST00000109901.2
ENSMUST00000168186.1
ENSMUST00000163473.1
ENSMUST00000170540.1
ENSMUST00000166735.1
ENSMUST00000170002.1
 Papola





poly (A) polymerase alpha





chr3_-_131344892 0.348 ENSMUST00000090246.4
ENSMUST00000126569.1
 Sgms2

sphingomyelin synthase 2

chr17_-_32189457 0.342 ENSMUST00000087721.3
ENSMUST00000162117.1
 Ephx3

epoxide hydrolase 3

chr17_+_27029259 0.300 ENSMUST00000053683.6
 Ggnbp1
gametogenetin binding protein 1
chr6_-_33060172 0.261 ENSMUST00000115091.1
ENSMUST00000127666.1
 Chchd3

coiled-coil-helix-coiled-coil-helix domain containing 3

chr5_+_30281377 0.206 ENSMUST00000101448.3
 Drc1
dynein regulatory complex subunit 1
chr6_-_24528013 0.199 ENSMUST00000023851.5
 Ndufa5
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
chr4_-_133633419 0.179 ENSMUST00000084238.4
 Zdhhc18
zinc finger, DHHC domain containing 18
chr18_-_46728342 0.177 ENSMUST00000035804.7
 Cdo1
cysteine dioxygenase 1, cytosolic
chr12_-_101958148 0.037 ENSMUST00000159883.1
ENSMUST00000160251.1
ENSMUST00000161011.1
ENSMUST00000021606.5
 Atxn3



ataxin 3



chrX_+_94724569 0.005 ENSMUST00000101388.2
 Zxdb
zinc finger, X-linked, duplicated B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 9.8 GO:0014826 vein smooth muscle contraction(GO:0014826)
2.3 6.9 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
1.8 5.4 GO:0060853 arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel endothelial cell fate specification(GO:0097101)
1.7 5.2 GO:0010248 B cell negative selection(GO:0002352) establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
1.3 11.8 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
1.1 6.3 GO:0098700 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) neurotransmitter loading into synaptic vesicle(GO:0098700)
1.0 8.2 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
1.0 2.9 GO:1900275 negative regulation of phospholipase C activity(GO:1900275)
0.8 2.4 GO:0018094 protein polyglycylation(GO:0018094)
0.7 2.1 GO:0002586 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588)
0.5 1.4 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.4 9.7 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.4 1.9 GO:0051012 microtubule sliding(GO:0051012)
0.4 5.7 GO:0035493 SNARE complex assembly(GO:0035493)
0.3 1.0 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.3 3.0 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.3 4.4 GO:0072010 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.3 2.3 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154) regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.2 0.6 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.2 0.5 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.1 2.4 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 2.9 GO:0005980 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.1 0.4 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.1 3.0 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.3 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 8.2 GO:0007050 cell cycle arrest(GO:0007050)
0.0 2.5 GO:0030901 midbrain development(GO:0030901)
0.0 0.6 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 1.7 GO:0007032 endosome organization(GO:0007032)
0.0 0.2 GO:0000098 sulfur amino acid catabolic process(GO:0000098) response to glucagon(GO:0033762)
0.0 6.1 GO:0051321 meiotic cell cycle(GO:0051321)
0.0 4.9 GO:0048864 stem cell development(GO:0048864)
0.0 0.3 GO:0042407 cristae formation(GO:0042407)
0.0 0.2 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.0 0.4 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.4 GO:0031440 regulation of mRNA 3'-end processing(GO:0031440)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.0 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.5 2.1 GO:0061702 inflammasome complex(GO:0061702)
0.4 6.3 GO:0031045 dense core granule(GO:0031045)
0.4 5.2 GO:0046930 pore complex(GO:0046930)
0.2 5.7 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.1 1.9 GO:0044447 axoneme part(GO:0044447)
0.1 8.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 4.9 GO:0005844 polysome(GO:0005844)
0.0 0.6 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 9.8 GO:0031965 nuclear membrane(GO:0031965)
0.0 2.3 GO:0045178 basal part of cell(GO:0045178)
0.0 0.3 GO:0061617 MICOS complex(GO:0061617)
0.0 0.5 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.7 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 0.6 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 5.4 GO:0016324 apical plasma membrane(GO:0016324)
0.0 3.3 GO:0000776 kinetochore(GO:0000776)
0.0 2.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 18.2 GO:0005615 extracellular space(GO:0005615)
0.0 1.2 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 8.2 GO:0030424 axon(GO:0030424)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 9.8 GO:0004962 endothelin receptor activity(GO:0004962)
2.1 6.3 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
1.6 8.2 GO:0032027 myosin light chain binding(GO:0032027)
0.7 2.9 GO:2001069 glycogen binding(GO:2001069)
0.6 9.7 GO:0008430 selenium binding(GO:0008430)
0.6 6.9 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.5 11.8 GO:0001784 phosphotyrosine binding(GO:0001784)
0.5 5.4 GO:0030957 Tat protein binding(GO:0030957)
0.4 2.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.4 5.2 GO:0051400 BH domain binding(GO:0051400)
0.3 1.0 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.3 2.1 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.2 2.9 GO:0070097 delta-catenin binding(GO:0070097)
0.2 5.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 4.9 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 0.3 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 0.4 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.6 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 1.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.5 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.5 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 3.0 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.0 4.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.2 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 2.6 GO:0003924 GTPase activity(GO:0003924)