Motif ID: Zbtb4
Z-value: 0.630
Transcription factors associated with Zbtb4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Zbtb4 | ENSMUSG00000018750.8 | Zbtb4 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zbtb4 | mm10_v2_chr11_+_69765899_69765925 | 0.42 | 2.9e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 9.7 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 0.7 | 2.2 | GO:2001139 | negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139) |
| 0.6 | 2.5 | GO:0051643 | endoplasmic reticulum localization(GO:0051643) |
| 0.6 | 1.8 | GO:0030070 | insulin processing(GO:0030070) |
| 0.4 | 1.2 | GO:0072076 | hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
| 0.4 | 1.1 | GO:0048352 | neural plate mediolateral regionalization(GO:0021998) mesoderm structural organization(GO:0048338) paraxial mesoderm structural organization(GO:0048352) |
| 0.4 | 1.8 | GO:1900170 | negative regulation of glucocorticoid mediated signaling pathway(GO:1900170) |
| 0.4 | 1.5 | GO:0097494 | regulation of vesicle size(GO:0097494) |
| 0.3 | 1.0 | GO:0003219 | cardiac right ventricle formation(GO:0003219) |
| 0.3 | 2.0 | GO:0035234 | ectopic germ cell programmed cell death(GO:0035234) |
| 0.3 | 2.5 | GO:0006004 | fucose metabolic process(GO:0006004) |
| 0.3 | 2.5 | GO:0035542 | regulation of SNARE complex assembly(GO:0035542) |
| 0.3 | 0.8 | GO:0002371 | dendritic cell cytokine production(GO:0002371) regulation of dendritic cell cytokine production(GO:0002730) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-beta biosynthetic process(GO:0045359) |
| 0.3 | 1.1 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.3 | 1.3 | GO:2000325 | regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327) |
| 0.3 | 0.5 | GO:0051490 | negative regulation of filopodium assembly(GO:0051490) |
| 0.2 | 0.9 | GO:1901475 | pyruvate transmembrane transport(GO:1901475) |
| 0.2 | 3.9 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.2 | 1.6 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.2 | 6.1 | GO:0014912 | negative regulation of smooth muscle cell migration(GO:0014912) |
| 0.2 | 1.1 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.2 | 2.4 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.2 | 0.7 | GO:1900740 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) regulation of membrane tubulation(GO:1903525) |
| 0.2 | 0.8 | GO:0070345 | negative regulation of fat cell proliferation(GO:0070345) |
| 0.1 | 2.9 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.1 | 1.1 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
| 0.1 | 2.5 | GO:0008209 | androgen metabolic process(GO:0008209) |
| 0.1 | 0.9 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.1 | 1.0 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.1 | 0.5 | GO:0046133 | pyrimidine ribonucleoside catabolic process(GO:0046133) |
| 0.1 | 0.4 | GO:0072365 | regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365) |
| 0.1 | 1.1 | GO:0031937 | positive regulation of chromatin silencing(GO:0031937) |
| 0.1 | 0.5 | GO:1903553 | positive regulation of extracellular exosome assembly(GO:1903553) |
| 0.1 | 0.5 | GO:0035093 | spermatogenesis, exchange of chromosomal proteins(GO:0035093) |
| 0.1 | 0.5 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 0.1 | 0.6 | GO:1903715 | regulation of aerobic respiration(GO:1903715) |
| 0.1 | 0.2 | GO:0010636 | positive regulation of mitochondrial fusion(GO:0010636) |
| 0.1 | 0.5 | GO:0032804 | negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804) |
| 0.1 | 0.4 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) |
| 0.1 | 0.3 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 0.1 | 1.6 | GO:0010763 | positive regulation of fibroblast migration(GO:0010763) |
| 0.1 | 2.5 | GO:0009214 | cyclic nucleotide catabolic process(GO:0009214) |
| 0.1 | 2.8 | GO:0001919 | regulation of receptor recycling(GO:0001919) |
| 0.1 | 0.4 | GO:0015808 | L-alanine transport(GO:0015808) |
| 0.1 | 3.6 | GO:0046847 | filopodium assembly(GO:0046847) |
| 0.1 | 0.3 | GO:0042045 | epithelial fluid transport(GO:0042045) |
| 0.0 | 0.6 | GO:0060055 | angiogenesis involved in wound healing(GO:0060055) |
| 0.0 | 1.0 | GO:0097320 | membrane tubulation(GO:0097320) |
| 0.0 | 0.2 | GO:0034145 | positive regulation of toll-like receptor 4 signaling pathway(GO:0034145) |
| 0.0 | 1.2 | GO:0010960 | magnesium ion homeostasis(GO:0010960) |
| 0.0 | 0.5 | GO:0006824 | cobalt ion transport(GO:0006824) |
| 0.0 | 0.6 | GO:0060213 | regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) |
| 0.0 | 0.2 | GO:1903912 | negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912) |
| 0.0 | 0.1 | GO:0015910 | peroxisomal long-chain fatty acid import(GO:0015910) |
| 0.0 | 0.1 | GO:0097500 | receptor localization to nonmotile primary cilium(GO:0097500) |
| 0.0 | 0.8 | GO:0001913 | T cell mediated cytotoxicity(GO:0001913) |
| 0.0 | 0.5 | GO:0016926 | protein desumoylation(GO:0016926) |
| 0.0 | 0.3 | GO:1904153 | negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153) |
| 0.0 | 0.7 | GO:1903779 | regulation of cardiac conduction(GO:1903779) |
| 0.0 | 0.7 | GO:0002076 | osteoblast development(GO:0002076) |
| 0.0 | 0.5 | GO:0001516 | prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457) |
| 0.0 | 0.5 | GO:0032438 | melanosome organization(GO:0032438) anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.0 | 0.2 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.0 | 0.9 | GO:1901998 | toxin transport(GO:1901998) |
| 0.0 | 0.1 | GO:0071895 | enamel mineralization(GO:0070166) odontoblast differentiation(GO:0071895) |
| 0.0 | 0.1 | GO:0070488 | neutrophil aggregation(GO:0070488) |
| 0.0 | 0.3 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
| 0.0 | 0.4 | GO:0046513 | ceramide biosynthetic process(GO:0046513) |
| 0.0 | 1.0 | GO:0002011 | morphogenesis of an epithelial sheet(GO:0002011) |
| 0.0 | 0.9 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
| 0.0 | 0.1 | GO:0046084 | adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084) |
| 0.0 | 2.4 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
| 0.0 | 0.3 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.0 | 0.3 | GO:0014898 | muscle hypertrophy in response to stress(GO:0003299) cardiac muscle hypertrophy in response to stress(GO:0014898) |
| 0.0 | 0.5 | GO:0006687 | glycosphingolipid metabolic process(GO:0006687) |
| 0.0 | 0.3 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.0 | 0.2 | GO:0090083 | regulation of inclusion body assembly(GO:0090083) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.5 | GO:0042642 | actomyosin, myosin complex part(GO:0042642) |
| 0.7 | 2.2 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.4 | 3.9 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.4 | 3.0 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.3 | 1.1 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
| 0.3 | 2.9 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.1 | 2.5 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 0.7 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.1 | 1.5 | GO:0031045 | dense core granule(GO:0031045) |
| 0.1 | 1.0 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.1 | 0.4 | GO:0017059 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.1 | 0.3 | GO:0031230 | intrinsic component of cell outer membrane(GO:0031230) integral component of cell outer membrane(GO:0045203) |
| 0.1 | 1.6 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 0.8 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.0 | 0.5 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 0.5 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.0 | 0.7 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 0.6 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.0 | 0.5 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 2.5 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 2.5 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 0.1 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.0 | 5.5 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.0 | 1.4 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.2 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 0.8 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 0.9 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.7 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.0 | 0.3 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 0.3 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 0.1 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
| 0.0 | 0.0 | GO:1902636 | kinociliary basal body(GO:1902636) |
| 0.0 | 0.2 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 2.9 | GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) |
| 0.7 | 2.2 | GO:0046911 | hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.6 | 2.5 | GO:0042806 | fucose binding(GO:0042806) |
| 0.6 | 2.4 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 0.5 | 1.8 | GO:0038049 | glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
| 0.4 | 2.9 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.3 | 2.0 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.3 | 1.6 | GO:0001640 | adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) kainate selective glutamate receptor activity(GO:0015277) |
| 0.3 | 1.6 | GO:0046404 | ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) |
| 0.3 | 1.0 | GO:0034481 | chondroitin sulfotransferase activity(GO:0034481) |
| 0.2 | 0.9 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 0.2 | 1.1 | GO:0098821 | BMP receptor activity(GO:0098821) |
| 0.2 | 6.1 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.2 | 3.6 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.2 | 2.5 | GO:0043008 | ATP-dependent protein binding(GO:0043008) |
| 0.1 | 0.4 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) |
| 0.1 | 2.4 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.1 | 1.1 | GO:0046790 | virion binding(GO:0046790) |
| 0.1 | 0.5 | GO:0070976 | calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976) |
| 0.1 | 0.4 | GO:0015173 | hydrogen:amino acid symporter activity(GO:0005280) aromatic amino acid transmembrane transporter activity(GO:0015173) |
| 0.1 | 0.5 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834) |
| 0.1 | 1.2 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.1 | 0.5 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) prostaglandin-E synthase activity(GO:0050220) |
| 0.1 | 0.5 | GO:0004609 | phosphatidylserine decarboxylase activity(GO:0004609) |
| 0.1 | 2.5 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 2.4 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.1 | 1.4 | GO:0008599 | protein phosphatase type 1 regulator activity(GO:0008599) |
| 0.1 | 0.6 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) |
| 0.1 | 0.3 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
| 0.1 | 0.8 | GO:0016505 | peptidase activator activity involved in apoptotic process(GO:0016505) |
| 0.1 | 0.9 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.1 | 0.5 | GO:0015087 | cobalt ion transmembrane transporter activity(GO:0015087) |
| 0.1 | 1.3 | GO:0032183 | SUMO binding(GO:0032183) |
| 0.1 | 1.6 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.1 | 1.0 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.1 | 0.4 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.0 | 0.2 | GO:0008808 | cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) |
| 0.0 | 1.4 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 0.3 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.0 | 2.5 | GO:0004112 | cyclic-nucleotide phosphodiesterase activity(GO:0004112) |
| 0.0 | 0.3 | GO:0070191 | methionine-R-sulfoxide reductase activity(GO:0070191) |
| 0.0 | 0.3 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 0.0 | 0.4 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.0 | 0.5 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
| 0.0 | 0.3 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.0 | 1.0 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 0.7 | GO:0042171 | lysophosphatidic acid acyltransferase activity(GO:0042171) |
| 0.0 | 3.3 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 0.8 | GO:0034930 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131) |
| 0.0 | 1.5 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 0.1 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
| 0.0 | 1.2 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.0 | 0.6 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 0.1 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 0.1 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.0 | 0.3 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.0 | 1.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.8 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.0 | 0.1 | GO:0050786 | icosatetraenoic acid binding(GO:0050543) arachidonic acid binding(GO:0050544) RAGE receptor binding(GO:0050786) |
