Motif ID: Zfp423

Z-value: 0.498


Transcription factors associated with Zfp423:

Gene SymbolEntrez IDGene Name
Zfp423 ENSMUSG00000045333.9 Zfp423

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp423mm10_v2_chr8_-_87959560_87959595-0.319.4e-03Click!


Activity profile for motif Zfp423.

activity profile for motif Zfp423


Sorted Z-values histogram for motif Zfp423

Sorted Z-values for motif Zfp423



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfp423

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_180499893 6.369 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr4_+_42917234 4.616 ENSMUST00000107976.2
ENSMUST00000069184.2
 N28178

expressed sequence N28178

chr14_+_119138415 4.147 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr5_-_22344690 4.053 ENSMUST00000062372.7
ENSMUST00000161356.1
 Reln

reelin

chr2_-_29253001 3.853 ENSMUST00000071201.4
 Ntng2
netrin G2
chr10_+_13966268 3.411 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr7_+_29307924 3.002 ENSMUST00000108230.1
ENSMUST00000065181.5
 Dpf1

D4, zinc and double PHD fingers family 1

chr15_-_66286224 2.577 ENSMUST00000070256.7
 Kcnq3
potassium voltage-gated channel, subfamily Q, member 3
chrX_+_7822289 2.542 ENSMUST00000009875.4
 Kcnd1
potassium voltage-gated channel, Shal-related family, member 1
chr14_+_70553687 2.534 ENSMUST00000161069.1
 Hr
hairless
chr10_-_62110945 2.486 ENSMUST00000142821.1
ENSMUST00000124615.1
ENSMUST00000064050.4
ENSMUST00000125704.1
ENSMUST00000142796.1
 2010107G23Rik




RIKEN cDNA 2010107G23 gene




chr19_+_6401675 2.350 ENSMUST00000113471.1
ENSMUST00000113469.2
 Rasgrp2

RAS, guanyl releasing protein 2

chr6_+_110645572 2.298 ENSMUST00000071076.6
ENSMUST00000172951.1
 Grm7

glutamate receptor, metabotropic 7

chr12_+_102948843 2.292 ENSMUST00000101099.5
 Unc79
unc-79 homolog (C. elegans)
chr5_-_135934590 2.174 ENSMUST00000055808.5
 Ywhag
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr7_-_105633525 2.137 ENSMUST00000153371.1
ENSMUST00000106789.1
ENSMUST00000057525.7
 Trim3


tripartite motif-containing 3


chr15_-_78718113 1.979 ENSMUST00000088592.4
 Elfn2
leucine rich repeat and fibronectin type III, extracellular 2
chr7_-_105633479 1.898 ENSMUST00000147044.1
ENSMUST00000106791.1
 Trim3

tripartite motif-containing 3

chr12_-_14152038 1.802 ENSMUST00000020926.6
 Fam84a
family with sequence similarity 84, member A
chr19_-_10869757 1.687 ENSMUST00000120524.1
ENSMUST00000025645.7
 Tmem132a

transmembrane protein 132A

chr11_-_94474088 1.508 ENSMUST00000107786.1
ENSMUST00000107791.1
ENSMUST00000103166.2
ENSMUST00000107792.1
ENSMUST00000100561.3
ENSMUST00000107793.1
ENSMUST00000107788.1
ENSMUST00000107790.1
ENSMUST00000107789.1
ENSMUST00000107785.1
ENSMUST00000021234.8
 Cacna1g










calcium channel, voltage-dependent, T type, alpha 1G subunit










chr8_+_58912257 1.450 ENSMUST00000160055.1
 BC030500
cDNA sequence BC030500
chr9_+_120492606 1.433 ENSMUST00000007139.4
 Eif1b
eukaryotic translation initiation factor 1B
chr2_+_164785823 1.431 ENSMUST00000174070.1
ENSMUST00000172577.1
ENSMUST00000056181.6
 Snx21


sorting nexin family member 21


chr17_+_55986494 1.416 ENSMUST00000011733.8
 Fsd1
fibronectin type 3 and SPRY domain-containing protein
chr9_-_37552904 1.410 ENSMUST00000065668.5
 Nrgn
neurogranin
chr7_-_25754701 1.387 ENSMUST00000108401.1
ENSMUST00000043765.7
 Hnrnpul1

heterogeneous nuclear ribonucleoprotein U-like 1

chr6_-_124415037 1.323 ENSMUST00000035861.5
ENSMUST00000112532.1
ENSMUST00000080557.5
 Pex5


peroxisomal biogenesis factor 5


chr17_+_69156791 1.310 ENSMUST00000112680.1
ENSMUST00000080208.5
 Epb4.1l3

erythrocyte protein band 4.1-like 3

chr2_+_164785994 1.292 ENSMUST00000152471.1
 Snx21
sorting nexin family member 21
chr11_+_82101836 1.153 ENSMUST00000000194.3
 Ccl12
chemokine (C-C motif) ligand 12
chr6_+_86628174 1.064 ENSMUST00000043400.6
 Asprv1
aspartic peptidase, retroviral-like 1
chr6_-_128200598 1.059 ENSMUST00000071101.6
 Gm10010
predicted gene 10010
chr19_+_4231899 0.887 ENSMUST00000025773.3
 Pold4
polymerase (DNA-directed), delta 4
chr7_-_19458494 0.879 ENSMUST00000085715.5
 Mark4
MAP/microtubule affinity-regulating kinase 4
chr15_+_89253035 0.853 ENSMUST00000088788.3
 Ppp6r2
protein phosphatase 6, regulatory subunit 2
chr19_+_10041548 0.828 ENSMUST00000115995.2
 Fads3
fatty acid desaturase 3
chr4_+_129513581 0.777 ENSMUST00000062356.6
 Marcksl1
MARCKS-like 1
chr4_+_31964081 0.761 ENSMUST00000037607.4
ENSMUST00000080933.6
ENSMUST00000108183.1
ENSMUST00000108184.2
 Map3k7



mitogen-activated protein kinase kinase kinase 7



chr14_-_70520254 0.710 ENSMUST00000022693.7
 Bmp1
bone morphogenetic protein 1
chr17_-_29347902 0.706 ENSMUST00000095427.4
ENSMUST00000118366.1
 Mtch1

mitochondrial carrier homolog 1 (C. elegans)

chr15_+_101174096 0.681 ENSMUST00000000544.9
 Acvr1b
activin A receptor, type 1B
chr7_-_120670256 0.675 ENSMUST00000033178.2
 Pdzd9
PDZ domain containing 9
chr8_-_83699095 0.653 ENSMUST00000005616.8
 Pkn1
protein kinase N1
chr2_-_30359278 0.634 ENSMUST00000163668.2
ENSMUST00000028214.8
ENSMUST00000113621.3
 Sh3glb2


SH3-domain GRB2-like endophilin B2


chr1_-_54926311 0.623 ENSMUST00000179030.1
ENSMUST00000044359.9
 Ankrd44

ankyrin repeat domain 44

chr11_-_33203588 0.614 ENSMUST00000037746.6
 Tlx3
T cell leukemia, homeobox 3
chr2_+_106693185 0.610 ENSMUST00000111063.1
 Mpped2
metallophosphoesterase domain containing 2
chr2_-_30359190 0.515 ENSMUST00000100215.4
ENSMUST00000113620.3
 Sh3glb2

SH3-domain GRB2-like endophilin B2

chr11_+_102836296 0.494 ENSMUST00000021302.8
ENSMUST00000107072.1
 Higd1b

HIG1 domain family, member 1B

chr4_-_117125618 0.476 ENSMUST00000183310.1
 Btbd19
BTB (POZ) domain containing 19
chr5_-_136565432 0.425 ENSMUST00000176172.1
 Cux1
cut-like homeobox 1
chr13_+_3538075 0.414 ENSMUST00000059515.6
 Gdi2
guanosine diphosphate (GDP) dissociation inhibitor 2
chr7_-_67372846 0.387 ENSMUST00000156690.1
ENSMUST00000107476.1
ENSMUST00000076325.5
ENSMUST00000032776.8
ENSMUST00000133074.1
 Mef2a




myocyte enhancer factor 2A




chr1_-_51941261 0.380 ENSMUST00000097103.3
 Gm8420
predicted gene 8420
chr8_-_41016749 0.377 ENSMUST00000117735.1
 Mtus1
mitochondrial tumor suppressor 1
chr10_-_14705459 0.348 ENSMUST00000149485.1
ENSMUST00000154132.1
 Vta1

Vps20-associated 1 homolog (S. cerevisiae)

chr9_+_57130690 0.339 ENSMUST00000160147.1
ENSMUST00000161663.1
ENSMUST00000034836.9
ENSMUST00000161182.1
 Man2c1



mannosidase, alpha, class 2C, member 1



chr9_-_21127346 0.298 ENSMUST00000001036.10
 Tyk2
tyrosine kinase 2
chr2_+_133552159 0.291 ENSMUST00000028836.6
 Bmp2
bone morphogenetic protein 2
chr12_+_69184158 0.276 ENSMUST00000060579.8
 Mgat2
mannoside acetylglucosaminyltransferase 2
chr5_+_24423805 0.251 ENSMUST00000153274.1
 Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr12_-_69183986 0.222 ENSMUST00000110620.1
ENSMUST00000110619.1
 Rpl36al

ribosomal protein L36A-like

chr7_+_127485221 0.204 ENSMUST00000048896.6
 Fbrs
fibrosin
chr6_-_124756478 0.149 ENSMUST00000088357.5
 Atn1
atrophin 1
chr7_-_105744312 0.137 ENSMUST00000141116.1
 Taf10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr17_-_35074485 0.099 ENSMUST00000007259.3
 Ly6g6d
lymphocyte antigen 6 complex, locus G6D
chr18_-_80151467 0.089 ENSMUST00000066743.9
 Adnp2
ADNP homeobox 2
chr7_-_5014645 0.056 ENSMUST00000165320.1
 Fiz1
Flt3 interacting zinc finger protein 1
chr6_-_97205549 0.051 ENSMUST00000164744.1
ENSMUST00000089287.5
 Uba3

ubiquitin-like modifier activating enzyme 3

chr7_-_34196608 0.046 ENSMUST00000148381.1
ENSMUST00000002710.3
 Pdcd2l

programmed cell death 2-like

chr12_-_69184056 0.045 ENSMUST00000054544.6
 Rpl36al
ribosomal protein L36A-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.4 GO:1903802 positive regulation of arachidonic acid secretion(GO:0090238) L-glutamate(1-) import into cell(GO:1903802) L-glutamate import into cell(GO:1990123)
1.0 4.1 GO:0097477 lateral motor column neuron migration(GO:0097477)
0.7 4.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.5 1.5 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.5 2.3 GO:0001661 conditioned taste aversion(GO:0001661)
0.4 1.3 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.4 1.2 GO:2000501 natural killer cell chemotaxis(GO:0035747) negative regulation of lymphocyte migration(GO:2000402) regulation of natural killer cell chemotaxis(GO:2000501)
0.2 2.3 GO:0048149 behavioral response to ethanol(GO:0048149)
0.2 2.6 GO:0060081 membrane hyperpolarization(GO:0060081)
0.2 0.7 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.2 0.8 GO:0097343 ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.1 0.4 GO:0070375 ERK5 cascade(GO:0070375)
0.1 0.3 GO:0060129 BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) thyroid-stimulating hormone-secreting cell differentiation(GO:0060129) mesenchymal cell proliferation involved in ureteric bud development(GO:0072138)
0.1 0.7 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.1 0.3 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.1 1.4 GO:1900273 positive regulation of long-term synaptic potentiation(GO:1900273)
0.0 2.3 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.3 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.9 GO:0000731 DNA synthesis involved in DNA repair(GO:0000731)
0.0 0.6 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 0.9 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 2.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.1 GO:0070365 hepatocyte differentiation(GO:0070365)
0.0 0.7 GO:0061036 positive regulation of cartilage development(GO:0061036)
0.0 0.4 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.3 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 2.5 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.0 2.5 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 0.1 GO:0009404 toxin metabolic process(GO:0009404)
0.0 0.1 GO:0007113 endomitotic cell cycle(GO:0007113)
0.0 2.2 GO:0048167 regulation of synaptic plasticity(GO:0048167)
0.0 0.7 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.4 GO:0032280 symmetric synapse(GO:0032280)
0.4 2.3 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.3 0.9 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.2 0.7 GO:0048179 activin receptor complex(GO:0048179)
0.1 1.4 GO:0044327 dendritic spine head(GO:0044327)
0.1 3.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 3.0 GO:0071565 nBAF complex(GO:0071565)
0.1 2.6 GO:0043194 axon initial segment(GO:0043194)
0.1 2.7 GO:0031901 early endosome membrane(GO:0031901)
0.1 1.3 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 4.1 GO:0043204 perikaryon(GO:0043204)
0.0 1.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 2.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.1 GO:0000125 PCAF complex(GO:0000125)
0.0 0.7 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 2.6 GO:0043209 myelin sheath(GO:0043209)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0070905 serine binding(GO:0070905)
0.7 4.0 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.5 2.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.4 1.5 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.3 6.4 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.3 1.2 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.3 1.3 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.2 0.7 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.2 0.7 GO:0016361 activin receptor activity, type I(GO:0016361)
0.2 2.5 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 4.1 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.1 1.1 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 0.4 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.1 2.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.4 GO:0070300 phosphatidic acid binding(GO:0070300)
0.1 2.2 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 0.3 GO:0005131 growth hormone receptor binding(GO:0005131)
0.1 0.3 GO:0019211 phosphatase activator activity(GO:0019211)
0.1 2.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.1 GO:0050827 toxin receptor binding(GO:0050827)
0.0 0.9 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 2.0 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.8 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 1.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.1 GO:0016215 acyl-CoA desaturase activity(GO:0016215)
0.0 3.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.7 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.3 GO:0044653 trehalase activity(GO:0015927) dextrin alpha-glucosidase activity(GO:0044653) starch alpha-glucosidase activity(GO:0044654) beta-glucanase activity(GO:0052736) beta-6-sulfate-N-acetylglucosaminidase activity(GO:0052769) glucan endo-1,4-beta-glucosidase activity(GO:0052859)
0.0 0.1 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.6 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)