Motif ID: Zic2

Z-value: 0.528


Transcription factors associated with Zic2:

Gene SymbolEntrez IDGene Name
Zic2 ENSMUSG00000061524.8 Zic2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic2mm10_v2_chr14_+_122475397_1224754350.319.3e-03Click!


Activity profile for motif Zic2.

activity profile for motif Zic2


Sorted Z-values histogram for motif Zic2

Sorted Z-values for motif Zic2



Network of associatons between targets according to the STRING database.



First level regulatory network of Zic2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_19699008 5.739 ENSMUST00000174355.1
ENSMUST00000172983.1
ENSMUST00000174710.1
ENSMUST00000167646.2
ENSMUST00000003066.9
ENSMUST00000174064.1
 Apoe





apolipoprotein E





chr7_-_19698206 3.011 ENSMUST00000172808.1
ENSMUST00000174191.1
 Apoe

apolipoprotein E

chr7_-_19698383 2.626 ENSMUST00000173739.1
 Apoe
apolipoprotein E
chr11_+_105292637 2.596 ENSMUST00000100335.3
ENSMUST00000021038.4
 Mrc2

mannose receptor, C type 2

chr14_+_27039001 2.586 ENSMUST00000035336.3
 Il17rd
interleukin 17 receptor D
chr5_+_140607334 2.554 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr7_+_117380937 2.411 ENSMUST00000032892.5
 Xylt1
xylosyltransferase 1
chr11_+_63128973 2.371 ENSMUST00000108702.1
 Pmp22
peripheral myelin protein 22
chr4_-_41503046 2.242 ENSMUST00000054920.4
 AI464131
expressed sequence AI464131
chr8_+_94179089 2.235 ENSMUST00000034215.6
 Mt1
metallothionein 1
chr4_-_143299498 2.214 ENSMUST00000030317.7
 Pdpn
podoplanin
chr15_-_8710409 2.199 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr10_-_42583628 2.168 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr4_-_143299463 2.165 ENSMUST00000119654.1
 Pdpn
podoplanin
chr9_+_104002546 2.054 ENSMUST00000035167.8
ENSMUST00000117054.1
 Nphp3

nephronophthisis 3 (adolescent)

chr14_+_19751257 1.963 ENSMUST00000022340.3
 Nid2
nidogen 2
chr2_-_122611238 1.904 ENSMUST00000028624.8
 Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr8_+_12395287 1.901 ENSMUST00000180353.1
 Sox1
SRY-box containing gene 1
chr17_+_86963279 1.896 ENSMUST00000139344.1
 Rhoq
ras homolog gene family, member Q
chr12_-_56536895 1.891 ENSMUST00000001536.8
 Nkx2-1
NK2 homeobox 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 196 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.8 11.4 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.3 5.3 GO:0032060 bleb assembly(GO:0032060)
0.4 4.4 GO:0061032 visceral serous pericardium development(GO:0061032)
0.4 3.6 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.2 3.4 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.5 2.6 GO:0007386 compartment pattern specification(GO:0007386)
0.3 2.6 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.3 2.4 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.3 2.3 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.3 2.3 GO:0051639 actin filament network formation(GO:0051639)
0.5 2.2 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.4 2.2 GO:0021764 amygdala development(GO:0021764)
0.3 2.2 GO:0010273 detoxification of copper ion(GO:0010273) cellular response to zinc ion(GO:0071294) stress response to copper ion(GO:1990169)
0.1 2.2 GO:0005980 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.7 2.1 GO:0048496 maintenance of organ identity(GO:0048496)
0.1 2.1 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.2 2.0 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.6 1.9 GO:0006601 creatine biosynthetic process(GO:0006601)
0.6 1.9 GO:0021759 globus pallidus development(GO:0021759)
0.1 1.9 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.8 11.4 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 6.1 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1 5.7 GO:0005604 basement membrane(GO:0005604)
0.0 4.5 GO:0030175 filopodium(GO:0030175)
0.0 4.3 GO:0000139 Golgi membrane(GO:0000139)
0.0 3.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 3.2 GO:0016324 apical plasma membrane(GO:0016324)
0.2 2.6 GO:0043205 fibril(GO:0043205)
0.1 2.4 GO:0043218 compact myelin(GO:0043218)
0.0 2.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.6 2.3 GO:0032127 dense core granule membrane(GO:0032127)
0.0 2.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 2.2 GO:0005884 actin filament(GO:0005884)
0.7 2.1 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 1.8 GO:0016607 nuclear speck(GO:0016607)
0.0 1.7 GO:0072562 blood microparticle(GO:0072562)
0.2 1.6 GO:0070531 BRCA1-A complex(GO:0070531)
0.3 1.5 GO:0044301 climbing fiber(GO:0044301)
0.0 1.5 GO:0005643 nuclear pore(GO:0005643)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 150 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.8 11.4 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0 5.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.4 4.4 GO:0008517 folic acid transporter activity(GO:0008517) water channel activity(GO:0015250)
0.2 3.6 GO:0001784 phosphotyrosine binding(GO:0001784)
0.3 3.4 GO:0005522 profilin binding(GO:0005522)
0.1 2.9 GO:0044653 trehalase activity(GO:0015927) dextrin alpha-glucosidase activity(GO:0044653) starch alpha-glucosidase activity(GO:0044654) beta-glucanase activity(GO:0052736) beta-6-sulfate-N-acetylglucosaminidase activity(GO:0052769) glucan endo-1,4-beta-glucosidase activity(GO:0052859)
0.9 2.6 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.9 2.6 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 2.6 GO:0005518 collagen binding(GO:0005518)
0.0 2.6 GO:0002039 p53 binding(GO:0002039)
0.0 2.6 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 2.6 GO:0051015 actin filament binding(GO:0051015)
0.8 2.4 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.1 2.4 GO:0017166 vinculin binding(GO:0017166)
0.4 2.2 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 2.0 GO:0033613 activating transcription factor binding(GO:0033613)
0.2 1.9 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.1 1.9 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 1.9 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 1.8 GO:0020037 heme binding(GO:0020037)