Motif ID: Zic4

Z-value: 0.897


Transcription factors associated with Zic4:

Gene SymbolEntrez IDGene Name
Zic4 ENSMUSG00000036972.8 Zic4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic4mm10_v2_chr9_+_91368811_91368828-0.263.0e-02Click!


Activity profile for motif Zic4.

activity profile for motif Zic4


Sorted Z-values histogram for motif Zic4

Sorted Z-values for motif Zic4



Network of associatons between targets according to the STRING database.



First level regulatory network of Zic4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_180499893 5.747 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr4_+_141368116 4.649 ENSMUST00000006380.4
 Fam131c
family with sequence similarity 131, member C
chr9_-_29412204 4.445 ENSMUST00000115237.1
 Ntm
neurotrimin
chr4_+_152338619 4.323 ENSMUST00000030775.5
ENSMUST00000164662.1
 Chd5

chromodomain helicase DNA binding protein 5

chr4_+_152338887 4.283 ENSMUST00000005175.4
 Chd5
chromodomain helicase DNA binding protein 5
chr19_+_47178820 3.549 ENSMUST00000111808.3
 Neurl1a
neuralized homolog 1A (Drosophila)
chr19_+_4099998 3.462 ENSMUST00000049658.7
 Pitpnm1
phosphatidylinositol transfer protein, membrane-associated 1
chr5_-_139325616 3.427 ENSMUST00000110865.1
 Adap1
ArfGAP with dual PH domains 1
chr2_-_152951456 3.317 ENSMUST00000123121.2
 Dusp15
dual specificity phosphatase-like 15
chr7_-_47133684 3.181 ENSMUST00000102626.1
 Ptpn5
protein tyrosine phosphatase, non-receptor type 5
chr17_-_29237759 3.144 ENSMUST00000137727.1
ENSMUST00000024805.7
 Cpne5

copine V

chr7_-_47133395 3.132 ENSMUST00000107617.1
 Ptpn5
protein tyrosine phosphatase, non-receptor type 5
chr19_+_4855129 3.055 ENSMUST00000119694.1
 Ctsf
cathepsin F
chr17_+_46297917 2.898 ENSMUST00000166617.1
ENSMUST00000170271.1
 Dlk2

delta-like 2 homolog (Drosophila)

chr6_-_35308110 2.894 ENSMUST00000031868.4
 Slc13a4
solute carrier family 13 (sodium/sulfate symporters), member 4
chr2_-_152951547 2.822 ENSMUST00000037715.6
 Dusp15
dual specificity phosphatase-like 15
chr2_-_152951688 2.724 ENSMUST00000109811.3
 Dusp15
dual specificity phosphatase-like 15
chr4_+_104367549 2.664 ENSMUST00000106830.2
 Dab1
disabled 1
chr11_+_98741805 2.661 ENSMUST00000064187.5
 Thra
thyroid hormone receptor alpha
chr1_+_91179822 2.617 ENSMUST00000097648.4
ENSMUST00000165855.1
 Ramp1

receptor (calcitonin) activity modifying protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 8.6 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0 6.9 GO:0046330 positive regulation of JNK cascade(GO:0046330)
1.3 6.3 GO:2001025 positive regulation of response to drug(GO:2001025)
1.4 5.7 GO:1903802 positive regulation of arachidonic acid secretion(GO:0090238) L-glutamate(1-) import into cell(GO:1903802) L-glutamate import into cell(GO:1990123)
1.7 5.2 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.4 3.5 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.1 3.1 GO:1903861 regulation of dendrite extension(GO:1903859) positive regulation of dendrite extension(GO:1903861)
1.0 2.9 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.0 2.9 GO:0045598 regulation of fat cell differentiation(GO:0045598)
0.9 2.7 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.2 2.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 2.7 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.5 2.6 GO:0060050 positive regulation of protein glycosylation(GO:0060050)
0.4 2.6 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.8 2.3 GO:1900736 regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900736)
0.1 2.3 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.1 2.2 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.3 1.9 GO:0061042 vascular wound healing(GO:0061042)
0.1 1.9 GO:1900452 regulation of long term synaptic depression(GO:1900452)
0.1 1.9 GO:2000811 negative regulation of anoikis(GO:2000811)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.6 GO:0031225 anchored component of membrane(GO:0031225)
0.3 7.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
1.1 6.3 GO:1990635 proximal dendrite(GO:1990635)
1.4 5.7 GO:0032280 symmetric synapse(GO:0032280)
0.1 3.5 GO:0097440 apical dendrite(GO:0097440)
0.0 3.2 GO:0005811 lipid particle(GO:0005811)
0.5 2.6 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 2.6 GO:0043235 receptor complex(GO:0043235)
0.1 2.5 GO:0031430 M band(GO:0031430)
0.0 2.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 2.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.9 GO:0005871 kinesin complex(GO:0005871)
0.0 1.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.8 GO:0005643 nuclear pore(GO:0005643)
0.4 1.7 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 1.5 GO:0005903 brush border(GO:0005903)
0.2 1.4 GO:0033391 chromatoid body(GO:0033391)
0.0 1.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 1.3 GO:0033010 paranodal junction(GO:0033010)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 8.2 GO:0035064 methylated histone binding(GO:0035064)
0.3 5.7 GO:0008188 neuropeptide receptor activity(GO:0008188)
1.7 5.2 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
0.1 3.9 GO:0045182 translation regulator activity(GO:0045182)
0.1 3.2 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 3.2 GO:0008201 heparin binding(GO:0008201)
0.0 3.2 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 3.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.2 2.9 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.1 2.8 GO:0042169 SH2 domain binding(GO:0042169)
0.2 2.7 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.7 2.6 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.4 2.6 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.2 2.6 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.2 2.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 2.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 2.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 1.7 GO:0008139 nuclear localization sequence binding(GO:0008139)