Motif ID: Zkscan3

Z-value: 0.407


Transcription factors associated with Zkscan3:

Gene SymbolEntrez IDGene Name
Zkscan3 ENSMUSG00000021327.12 Zkscan3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zkscan3mm10_v2_chr13_-_21402688_21402755-0.181.4e-01Click!


Activity profile for motif Zkscan3.

activity profile for motif Zkscan3


Sorted Z-values histogram for motif Zkscan3

Sorted Z-values for motif Zkscan3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zkscan3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_97459279 2.668 ENSMUST00000113359.1
 Frmd4b
FERM domain containing 4B
chr5_+_24985840 2.122 ENSMUST00000075081.6
 1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr12_+_112588753 1.928 ENSMUST00000101029.2
 Inf2
inverted formin, FH2 and WH2 domain containing
chr5_-_73338580 1.679 ENSMUST00000087195.5
 Ociad2
OCIA domain containing 2
chr13_+_42709482 1.563 ENSMUST00000066928.5
ENSMUST00000148891.1
 Phactr1

phosphatase and actin regulator 1

chr2_-_66634952 1.556 ENSMUST00000100064.2
ENSMUST00000100063.2
 Scn9a

sodium channel, voltage-gated, type IX, alpha

chr14_+_51893610 1.552 ENSMUST00000047726.5
ENSMUST00000161888.1
 Slc39a2

solute carrier family 39 (zinc transporter), member 2

chr1_-_40790642 1.225 ENSMUST00000039672.5
 Mfsd9
major facilitator superfamily domain containing 9
chr11_+_116918844 1.206 ENSMUST00000103027.3
 Mgat5b
mannoside acetylglucosaminyltransferase 5, isoenzyme B
chr2_+_156613664 1.205 ENSMUST00000169464.2
ENSMUST00000109567.3
 Dlgap4

discs, large homolog-associated protein 4 (Drosophila)

chr2_+_155775333 1.153 ENSMUST00000029141.5
 Mmp24
matrix metallopeptidase 24
chr19_-_10869757 1.101 ENSMUST00000120524.1
ENSMUST00000025645.7
 Tmem132a

transmembrane protein 132A

chr18_+_61105844 1.072 ENSMUST00000115268.3
 Csf1r
colony stimulating factor 1 receptor
chr8_-_105758570 1.066 ENSMUST00000155038.2
ENSMUST00000013294.9
 Gfod2

glucose-fructose oxidoreductase domain containing 2

chr2_-_30194112 1.058 ENSMUST00000113659.1
ENSMUST00000113660.1
 Ccbl1

cysteine conjugate-beta lyase 1

chr6_+_127453705 1.008 ENSMUST00000039680.5
 Parp11
poly (ADP-ribose) polymerase family, member 11
chr1_-_173333503 0.969 ENSMUST00000038227.4
 Darc
Duffy blood group, chemokine receptor
chr2_+_104095796 0.887 ENSMUST00000040423.5
ENSMUST00000168176.1
 Cd59a

CD59a antigen

chr5_-_88675190 0.815 ENSMUST00000133532.1
ENSMUST00000150438.1
 Grsf1

G-rich RNA sequence binding factor 1

chr11_-_102218923 0.812 ENSMUST00000131254.1
 Hdac5
histone deacetylase 5
chr6_-_113719880 0.787 ENSMUST00000064993.5
 Ghrl
ghrelin
chr8_-_70760889 0.772 ENSMUST00000038626.8
 Mpv17l2
MPV17 mitochondrial membrane protein-like 2
chr11_-_88851462 0.771 ENSMUST00000107903.1
 Akap1
A kinase (PRKA) anchor protein 1
chr4_+_156026120 0.752 ENSMUST00000103173.3
 Tnfrsf18
tumor necrosis factor receptor superfamily, member 18
chr7_-_98178254 0.719 ENSMUST00000040971.7
 Capn5
calpain 5
chr13_+_104109737 0.710 ENSMUST00000044385.7
 Sgtb
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr13_-_38658991 0.703 ENSMUST00000001757.7
 Eef1e1
eukaryotic translation elongation factor 1 epsilon 1
chr8_+_106893616 0.691 ENSMUST00000047629.5
 Cirh1a
cirrhosis, autosomal recessive 1A (human)
chr9_+_114688782 0.691 ENSMUST00000047404.6
 Dync1li1
dynein cytoplasmic 1 light intermediate chain 1
chr8_-_116978908 0.679 ENSMUST00000070577.5
 1700030J22Rik
RIKEN cDNA 1700030J22 gene
chr6_+_125552948 0.660 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
 Vwf


Von Willebrand factor homolog


chr12_+_76533540 0.651 ENSMUST00000075249.4
 Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr14_+_57424054 0.630 ENSMUST00000122063.1
 Ift88
intraflagellar transport 88
chr2_+_121171155 0.586 ENSMUST00000110658.1
 Tubgcp4
tubulin, gamma complex associated protein 4
chr8_-_106893515 0.581 ENSMUST00000176090.1
 Chtf8
CTF8, chromosome transmission fidelity factor 8
chr13_-_19395728 0.576 ENSMUST00000039694.7
 Stard3nl
STARD3 N-terminal like
chr1_+_132298606 0.564 ENSMUST00000046071.4
 Klhdc8a
kelch domain containing 8A
chr11_-_102365111 0.564 ENSMUST00000006749.9
 Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr8_+_94810446 0.561 ENSMUST00000034232.1
 Ccl17
chemokine (C-C motif) ligand 17
chr19_+_6276725 0.549 ENSMUST00000025684.3
 Ehd1
EH-domain containing 1
chr5_+_117976761 0.520 ENSMUST00000035579.6
 Fbxo21
F-box protein 21
chr17_+_46110982 0.517 ENSMUST00000024763.3
ENSMUST00000123646.1
 Mrps18a

mitochondrial ribosomal protein S18A

chr4_+_63544747 0.498 ENSMUST00000035301.6
 Atp6v1g1
ATPase, H+ transporting, lysosomal V1 subunit G1
chr8_-_124897685 0.495 ENSMUST00000098312.2
 Exoc8
exocyst complex component 8
chr8_+_70616816 0.474 ENSMUST00000052437.3
 Lrrc25
leucine rich repeat containing 25
chr6_+_127453667 0.464 ENSMUST00000112193.1
 Parp11
poly (ADP-ribose) polymerase family, member 11
chr8_+_31091593 0.440 ENSMUST00000161713.1
 Dusp26
dual specificity phosphatase 26 (putative)
chr6_-_122856151 0.436 ENSMUST00000042081.8
 C3ar1
complement component 3a receptor 1
chr13_+_44730726 0.419 ENSMUST00000173704.1
ENSMUST00000044608.7
ENSMUST00000173367.1
 Jarid2


jumonji, AT rich interactive domain 2


chr8_-_106893581 0.405 ENSMUST00000176437.1
ENSMUST00000177068.1
ENSMUST00000169312.1
ENSMUST00000176515.1
 Chtf8



CTF8, chromosome transmission fidelity factor 8



chr16_-_16359016 0.382 ENSMUST00000023477.7
ENSMUST00000096229.3
ENSMUST00000115749.1
 Dnm1l


dynamin 1-like


chr7_-_27228605 0.375 ENSMUST00000003850.7
 Itpkc
inositol 1,4,5-trisphosphate 3-kinase C
chr2_+_32646586 0.363 ENSMUST00000009705.7
ENSMUST00000167841.1
 Eng

endoglin

chr13_+_104109752 0.362 ENSMUST00000160322.1
ENSMUST00000159574.1
 Sgtb

small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta

chr2_+_121171204 0.335 ENSMUST00000039541.5
ENSMUST00000110657.1
 Tubgcp4

tubulin, gamma complex associated protein 4

chr10_+_89744988 0.295 ENSMUST00000020112.5
 Uhrf1bp1l
UHRF1 (ICBP90) binding protein 1-like
chr9_+_87144285 0.281 ENSMUST00000113149.1
ENSMUST00000143779.1
ENSMUST00000179313.1
ENSMUST00000049457.7
ENSMUST00000153444.1
 Mrap2




melanocortin 2 receptor accessory protein 2




chr17_-_24150910 0.272 ENSMUST00000052462.6
 Pdpk1
3-phosphoinositide dependent protein kinase 1
chr4_+_156026304 0.266 ENSMUST00000040274.7
ENSMUST00000122001.1
 Tnfrsf18

tumor necrosis factor receptor superfamily, member 18

chr7_+_126759601 0.254 ENSMUST00000050201.4
ENSMUST00000057669.9
 Mapk3

mitogen-activated protein kinase 3

chr5_+_24586721 0.234 ENSMUST00000121863.1
ENSMUST00000088295.4
 Chpf2

chondroitin polymerizing factor 2

chr8_+_33732237 0.193 ENSMUST00000171010.1
 Gtf2e2
general transcription factor II E, polypeptide 2 (beta subunit)
chr5_-_88675613 0.187 ENSMUST00000113234.1
ENSMUST00000153565.1
 Grsf1

G-rich RNA sequence binding factor 1

chr13_-_104109576 0.140 ENSMUST00000109315.3
 Nln
neurolysin (metallopeptidase M3 family)
chr6_-_43666158 0.131 ENSMUST00000114644.2
ENSMUST00000150599.1
ENSMUST00000067888.7
 Tpk1


thiamine pyrophosphokinase


chr18_-_34651703 0.123 ENSMUST00000025228.5
ENSMUST00000133181.1
 Cdc23

CDC23 cell division cycle 23

chr3_-_63929376 0.098 ENSMUST00000061706.6
 E130311K13Rik
RIKEN cDNA E130311K13 gene
chr11_-_100650693 0.079 ENSMUST00000103119.3
 Zfp385c
zinc finger protein 385C
chr2_+_121295437 0.026 ENSMUST00000110639.1
 Map1a
microtubule-associated protein 1 A
chr1_+_37997975 0.012 ENSMUST00000027252.7
 Eif5b
eukaryotic translation initiation factor 5B
chr4_-_155863362 0.008 ENSMUST00000030949.3
 Tas1r3
taste receptor, type 1, member 3
chr10_-_33951190 0.007 ENSMUST00000048222.4
 Zufsp
zinc finger with UFM1-specific peptidase domain

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.3 0.8 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) positive regulation of cortisol secretion(GO:0051464)
0.2 0.6 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.1 0.9 GO:0090272 negative regulation of fibroblast growth factor production(GO:0090272)
0.1 0.4 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.1 0.4 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.1 0.7 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.1 0.5 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.1 0.9 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.1 0.8 GO:0061668 mitochondrial ribosome assembly(GO:0061668)
0.1 1.0 GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein(GO:0042511)
0.1 1.0 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 2.3 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.1 0.4 GO:0003032 detection of oxygen(GO:0003032)
0.1 0.8 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.1 1.2 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
0.1 0.7 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.1 0.5 GO:0001927 exocyst assembly(GO:0001927)
0.1 0.8 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.1 0.3 GO:0000189 MAPK import into nucleus(GO:0000189)
0.1 2.7 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 1.6 GO:0048266 behavioral response to pain(GO:0048266)
0.0 1.6 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.6 GO:0006968 cellular defense response(GO:0006968)
0.0 0.1 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
0.0 0.4 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.6 GO:0014823 response to activity(GO:0014823)
0.0 1.5 GO:0006998 nuclear envelope organization(GO:0006998)
0.0 0.3 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.0 1.6 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.7 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 1.2 GO:0006487 protein N-linked glycosylation(GO:0006487)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.3 0.9 GO:0005816 spindle pole body(GO:0005816)
0.2 0.7 GO:0034455 t-UTP complex(GO:0034455)
0.2 0.5 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.1 0.7 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 1.0 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 0.8 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 1.6 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 0.6 GO:0060091 kinocilium(GO:0060091)
0.1 0.7 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 0.2 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.1 0.8 GO:0030061 mitochondrial crista(GO:0030061)
0.0 1.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.5 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.5 GO:0000145 exocyst(GO:0000145)
0.0 0.7 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 1.0 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.5 GO:0005643 nuclear pore(GO:0005643)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)
0.0 0.5 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 2.7 GO:0001726 ruffle(GO:0001726)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.2 0.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 0.4 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 0.4 GO:0004942 anaphylatoxin receptor activity(GO:0004942)
0.1 0.4 GO:0005534 galactose binding(GO:0005534)
0.1 0.8 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.1 0.9 GO:0051011 microtubule minus-end binding(GO:0051011)
0.1 0.3 GO:0031779 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.1 1.6 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 1.0 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 1.6 GO:0031402 sodium ion binding(GO:0031402)
0.1 0.7 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 1.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 0.8 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 1.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 1.0 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 0.8 GO:0001848 complement binding(GO:0001848)
0.1 0.4 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.1 0.8 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.5 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.6 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.0 0.1 GO:0070012 oligopeptidase activity(GO:0070012)
0.0 0.3 GO:0016004 phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229)
0.0 1.1 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
0.0 1.2 GO:0045296 cadherin binding(GO:0045296)
0.0 0.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.1 GO:0016778 diphosphotransferase activity(GO:0016778)
0.0 0.5 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 1.9 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 1.1 GO:0019955 cytokine binding(GO:0019955)
0.0 0.4 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.3 GO:0001784 phosphotyrosine binding(GO:0001784)