Motif ID: Aire

Z-value: 0.609


Transcription factors associated with Aire:

Gene SymbolEntrez IDGene Name
Aire ENSMUSG00000000731.9 Aire



Activity profile for motif Aire.

activity profile for motif Aire


Sorted Z-values histogram for motif Aire

Sorted Z-values for motif Aire



Network of associatons between targets according to the STRING database.



First level regulatory network of Aire

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_61185558 2.759 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr3_-_116968969 1.577 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr5_-_135251209 1.458 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr9_-_124493793 1.336 ENSMUST00000178787.1
 Gm21836
predicted gene, 21836
chr5_+_43672289 1.260 ENSMUST00000156034.1
 Cc2d2a
coiled-coil and C2 domain containing 2A
chr19_-_28963863 1.232 ENSMUST00000161813.1
 4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr16_+_36875119 1.225 ENSMUST00000135406.1
ENSMUST00000114812.1
ENSMUST00000134616.1
ENSMUST00000023534.6
 Golgb1


Golgb1
golgi autoantigen, golgin subfamily b, macrogolgin 1


golgi autoantigen, golgin subfamily b, macrogolgin 1
chrM_+_11734 1.031 ENSMUST00000082418.1
 mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr7_-_127895578 0.964 ENSMUST00000033074.6
 Vkorc1
vitamin K epoxide reductase complex, subunit 1
chr11_-_69695802 0.882 ENSMUST00000108649.1
ENSMUST00000174159.1
ENSMUST00000181810.1
 BC096441

Tnfsf12
cDNA sequence BC096441

tumor necrosis factor (ligand) superfamily, member 12
chr12_+_84052114 0.819 ENSMUST00000120927.1
 Acot3
acyl-CoA thioesterase 3
chr14_+_76476913 0.816 ENSMUST00000140251.2
 Tsc22d1
TSC22 domain family, member 1
chr5_-_84417359 0.763 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr12_-_78983476 0.756 ENSMUST00000070174.7
 Tmem229b
transmembrane protein 229B
chr14_+_124005355 0.751 ENSMUST00000166105.1
 Gm17615
predicted gene, 17615
chr3_-_95217877 0.742 ENSMUST00000136139.1
 Gabpb2
GA repeat binding protein, beta 2
chr9_-_108263706 0.738 ENSMUST00000171412.1
 Dag1
dystroglycan 1
chr2_+_175283298 0.686 ENSMUST00000098998.3
 Gm14440
predicted gene 14440
chr19_+_3323301 0.649 ENSMUST00000025835.4
 Cpt1a
carnitine palmitoyltransferase 1a, liver
chr4_-_19570073 0.647 ENSMUST00000029885.4
 Cpne3
copine III
chr11_-_69696058 0.647 ENSMUST00000094070.4
ENSMUST00000180587.1
 BC096441
Tnfsf12
cDNA sequence BC096441
tumor necrosis factor (ligand) superfamily, member 12
chr7_-_126922887 0.620 ENSMUST00000134134.1
ENSMUST00000119781.1
ENSMUST00000121612.2
 Tmem219


transmembrane protein 219


chr9_-_97111117 0.597 ENSMUST00000085206.4
 Slc25a36
solute carrier family 25, member 36
chr2_+_176431829 0.595 ENSMUST00000172025.1
 Gm14435
predicted gene 14435
chr5_+_140735526 0.579 ENSMUST00000120630.2
 Amz1
archaelysin family metallopeptidase 1
chr16_-_91618986 0.529 ENSMUST00000143058.1
ENSMUST00000049244.8
ENSMUST00000169982.1
ENSMUST00000133731.1
 Dnajc28



DnaJ (Hsp40) homolog, subfamily C, member 28



chr18_+_37725706 0.508 ENSMUST00000066149.6
 Pcdhga9
protocadherin gamma subfamily A, 9
chr12_-_104865076 0.505 ENSMUST00000109937.1
ENSMUST00000109936.1
 Clmn

calmin

chr5_-_124354671 0.457 ENSMUST00000031341.4
 Cdk2ap1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
chr15_+_101266839 0.457 ENSMUST00000023779.6
 Nr4a1
nuclear receptor subfamily 4, group A, member 1
chr14_+_21481428 0.446 ENSMUST00000182996.1
 Kat6b
K(lysine) acetyltransferase 6B
chr18_+_37400845 0.434 ENSMUST00000057228.1
 Pcdhb9
protocadherin beta 9
chr8_-_109962127 0.431 ENSMUST00000001722.7
ENSMUST00000051430.6
 Marveld3

MARVEL (membrane-associating) domain containing 3

chr6_-_148896150 0.423 ENSMUST00000072324.5
ENSMUST00000111569.2
 Caprin2

caprin family member 2

chr19_-_4191035 0.407 ENSMUST00000045864.2
 Tbc1d10c
TBC1 domain family, member 10c
chr17_-_6961156 0.398 ENSMUST00000063683.6
 Tagap1
T cell activation GTPase activating protein 1
chrM_-_14060 0.398 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr8_+_69808672 0.387 ENSMUST00000036074.8
ENSMUST00000123453.1
 Gmip

Gem-interacting protein

chr14_-_18894255 0.380 ENSMUST00000124353.1
 Ube2e2
ubiquitin-conjugating enzyme E2E 2
chr8_-_4217133 0.364 ENSMUST00000175906.1
 BC068157
cDNA sequence BC068157
chr1_-_128359610 0.361 ENSMUST00000027601.4
 Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr6_+_42245907 0.360 ENSMUST00000031897.5
 Gstk1
glutathione S-transferase kappa 1
chr2_-_165400398 0.360 ENSMUST00000029213.4
 Ocstamp
osteoclast stimulatory transmembrane protein
chr1_-_90843916 0.338 ENSMUST00000130846.2
ENSMUST00000097653.4
ENSMUST00000056925.9
 Col6a3


collagen, type VI, alpha 3


chr10_+_52358767 0.338 ENSMUST00000180473.1
 Gm26741
predicted gene, 26741
chr13_-_110280103 0.333 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr4_+_42714926 0.323 ENSMUST00000178454.1
 Gm21955
predicted gene, 21955
chr16_-_36874806 0.317 ENSMUST00000075946.5
 Eaf2
ELL associated factor 2
chr3_+_89715016 0.316 ENSMUST00000098924.2
 Adar
adenosine deaminase, RNA-specific
chr2_-_134644079 0.314 ENSMUST00000110119.1
 Tmx4
thioredoxin-related transmembrane protein 4
chr4_+_11758147 0.308 ENSMUST00000029871.5
ENSMUST00000108303.1
 Cdh17

cadherin 17

chr2_+_172248492 0.308 ENSMUST00000038532.1
 Mc3r
melanocortin 3 receptor
chr1_+_65186727 0.307 ENSMUST00000097707.4
ENSMUST00000081154.7
 Pikfyve

phosphoinositide kinase, FYVE finger containing

chr8_-_4216912 0.294 ENSMUST00000177491.1
 BC068157
cDNA sequence BC068157
chr12_+_4843303 0.291 ENSMUST00000053034.4
 BC068281
cDNA sequence BC068281
chr13_-_62371936 0.269 ENSMUST00000107989.3
 Gm3604
predicted gene 3604
chr3_+_88835231 0.265 ENSMUST00000107498.2
 Gon4l
gon-4-like (C.elegans)
chr7_+_45896941 0.264 ENSMUST00000069772.7
ENSMUST00000107716.1
 Tmem143

transmembrane protein 143

chr13_+_49504774 0.236 ENSMUST00000051504.7
 Ecm2
extracellular matrix protein 2, female organ and adipocyte specific
chr9_+_13662460 0.223 ENSMUST00000177755.1
 Maml2
mastermind like 2 (Drosophila)
chr9_-_53610329 0.210 ENSMUST00000034547.5
 Acat1
acetyl-Coenzyme A acetyltransferase 1
chr8_+_111643425 0.206 ENSMUST00000077791.6
 Zfp1
zinc finger protein 1
chr2_-_134644125 0.192 ENSMUST00000038228.4
 Tmx4
thioredoxin-related transmembrane protein 4
chr4_+_154869585 0.188 ENSMUST00000079269.7
ENSMUST00000163732.1
ENSMUST00000080559.6
 Mmel1


membrane metallo-endopeptidase-like 1


chr11_-_115627948 0.186 ENSMUST00000154623.1
ENSMUST00000106503.3
ENSMUST00000141614.1
 Slc25a19


solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19


chr10_-_81014902 0.185 ENSMUST00000126317.1
ENSMUST00000092285.3
ENSMUST00000117805.1
 Gng7


guanine nucleotide binding protein (G protein), gamma 7


chr5_+_114896936 0.176 ENSMUST00000031542.9
ENSMUST00000146072.1
ENSMUST00000150361.1
 Oasl2


2'-5' oligoadenylate synthetase-like 2


chr7_-_121981669 0.173 ENSMUST00000057576.7
 Cog7
component of oligomeric golgi complex 7
chr7_-_115846080 0.160 ENSMUST00000166207.1
 Sox6
SRY-box containing gene 6
chr5_+_30921867 0.148 ENSMUST00000123885.1
 Khk
ketohexokinase
chr1_-_5070281 0.147 ENSMUST00000147158.1
ENSMUST00000118000.1
 Rgs20

regulator of G-protein signaling 20

chr7_+_45897429 0.141 ENSMUST00000140243.1
 Tmem143
transmembrane protein 143
chr17_-_35516780 0.136 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
 Tcf19


transcription factor 19


chr3_-_62506970 0.128 ENSMUST00000029336.4
 Dhx36
DEAH (Asp-Glu-Ala-His) box polypeptide 36
chr5_+_30921825 0.123 ENSMUST00000117435.1
 Khk
ketohexokinase
chr10_-_111997204 0.122 ENSMUST00000074805.5
 Glipr1
GLI pathogenesis-related 1 (glioma)
chrX_+_48256854 0.121 ENSMUST00000080713.4
 Utp14a
UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chr3_-_89411781 0.120 ENSMUST00000107429.3
ENSMUST00000129308.2
ENSMUST00000107426.1
ENSMUST00000050398.4
ENSMUST00000162701.1
 Flad1




RFad1, flavin adenine dinucleotide synthetase, homolog (yeast)




chr1_-_171059390 0.118 ENSMUST00000164044.1
ENSMUST00000169017.1
 Fcgr3

Fc receptor, IgG, low affinity III

chr5_+_29378604 0.115 ENSMUST00000181005.1
 4632411P08Rik
RIKEN cDNA 4632411P08 gene
chr2_-_94010729 0.113 ENSMUST00000040005.6
ENSMUST00000126378.1
 Alkbh3

alkB, alkylation repair homolog 3 (E. coli)

chr11_+_3963970 0.103 ENSMUST00000020705.4
ENSMUST00000109985.1
 Pes1

pescadillo homolog 1, containing BRCT domain (zebrafish)

chr11_+_69914179 0.094 ENSMUST00000057884.5
 Gps2
G protein pathway suppressor 2
chr12_+_36157124 0.091 ENSMUST00000041640.3
 Ankmy2
ankyrin repeat and MYND domain containing 2
chr8_+_64947177 0.076 ENSMUST00000079896.7
ENSMUST00000026595.5
 Tmem192

transmembrane protein 192

chr8_-_4217261 0.075 ENSMUST00000168386.2
 BC068157
cDNA sequence BC068157
chr10_+_53337686 0.065 ENSMUST00000046221.6
ENSMUST00000163319.1
 Pln

phospholamban

chr7_-_103741322 0.063 ENSMUST00000051346.2
 Olfr629
olfactory receptor 629
chr2_-_94010807 0.055 ENSMUST00000111240.1
 Alkbh3
alkB, alkylation repair homolog 3 (E. coli)
chrX_-_38576166 0.045 ENSMUST00000050083.5
 Cul4b
cullin 4B
chr5_+_130369420 0.042 ENSMUST00000086029.3
 Caln1
calneuron 1
chr11_+_105975204 0.035 ENSMUST00000001964.7
 Ace
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chrM_+_14138 0.030 ENSMUST00000082421.1
 mt-Cytb
mitochondrially encoded cytochrome b
chr17_+_22689771 0.027 ENSMUST00000055305.8
 Gm9805
predicted gene 9805
chr15_+_10981747 0.020 ENSMUST00000070877.5
 Amacr
alpha-methylacyl-CoA racemase
chr2_+_164948219 0.017 ENSMUST00000017881.2
 Mmp9
matrix metallopeptidase 9
chr11_+_67052641 0.003 ENSMUST00000108690.3
ENSMUST00000092996.4
 Sco1

SCO cytochrome oxidase deficient homolog 1 (yeast)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.2 1.3 GO:1903887 motile primary cilium assembly(GO:1903887) protein localization to ciliary transition zone(GO:1904491)
0.2 0.8 GO:0032788 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.2 0.7 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.2 0.6 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.4 GO:0034241 positive regulation of macrophage fusion(GO:0034241) regulation of osteoclast proliferation(GO:0090289)
0.1 0.8 GO:0032196 transposition(GO:0032196)
0.1 0.3 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.1 0.3 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.3 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.1 0.8 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 0.5 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1 0.2 GO:0035552 oxidative single-stranded DNA demethylation(GO:0035552)
0.1 0.6 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.1 0.4 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.4 GO:1902414 protein localization to cell junction(GO:1902414)
0.0 0.4 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.0 0.1 GO:0001803 antibody-dependent cellular cytotoxicity(GO:0001788) type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
0.0 0.3 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 1.1 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.5 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.6 GO:0006862 nucleotide transport(GO:0006862)
0.0 1.5 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.0 1.5 GO:0035567 non-canonical Wnt signaling pathway(GO:0035567)
0.0 0.2 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.0 GO:1903596 regulation of gap junction assembly(GO:1903596)
0.0 0.1 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.0 0.3 GO:0060259 regulation of feeding behavior(GO:0060259)
0.0 0.2 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.3 GO:0032288 myelin assembly(GO:0032288)
0.0 0.2 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.0 0.1 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.4 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0016011 dystroglycan complex(GO:0016011)
0.1 1.9 GO:0031527 filopodium membrane(GO:0031527)
0.1 1.3 GO:0036038 MKS complex(GO:0036038)
0.1 0.3 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.7 GO:0017119 Golgi transport complex(GO:0017119)
0.0 1.2 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.4 GO:0042555 MCM complex(GO:0042555)
0.0 0.6 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.4 GO:0043235 receptor complex(GO:0043235)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.0 GO:0070469 respiratory chain(GO:0070469)
0.0 0.1 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.1 0.3 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.1 0.3 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.3 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 0.8 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 0.3 GO:0004454 ketohexokinase activity(GO:0004454)
0.1 0.2 GO:0070052 collagen V binding(GO:0070052)
0.1 1.0 GO:0048038 quinone binding(GO:0048038)
0.1 1.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.4 GO:0042296 ISG15 transferase activity(GO:0042296)
0.1 0.2 GO:0051747 cytosine C-5 DNA demethylase activity(GO:0051747)
0.1 1.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 1.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.7 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 0.8 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.1 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.3 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.2 GO:0016453 acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.0 0.6 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.0 0.1 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.5 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.4 GO:0015035 glutathione peroxidase activity(GO:0004602) protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.0 0.4 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.3 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.1 GO:0004984 olfactory receptor activity(GO:0004984)