Motif ID: Aire

Z-value: 0.609


Transcription factors associated with Aire:

Gene SymbolEntrez IDGene Name
Aire ENSMUSG00000000731.9 Aire



Activity profile for motif Aire.

activity profile for motif Aire


Sorted Z-values histogram for motif Aire

Sorted Z-values for motif Aire



Network of associatons between targets according to the STRING database.



First level regulatory network of Aire

PNG image of the network

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Top targets:


Showing 1 to 20 of 97 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_61185558 2.759 ENSMUST00000166381.1
Cdr1
cerebellar degeneration related antigen 1
chr3_-_116968969 1.577 ENSMUST00000143611.1
ENSMUST00000040097.7
Palmd

palmdelphin

chr5_-_135251209 1.458 ENSMUST00000062572.2
Fzd9
frizzled homolog 9 (Drosophila)
chr9_-_124493793 1.336 ENSMUST00000178787.1
Gm21836
predicted gene, 21836
chr5_+_43672289 1.260 ENSMUST00000156034.1
Cc2d2a
coiled-coil and C2 domain containing 2A
chr19_-_28963863 1.232 ENSMUST00000161813.1
4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr16_+_36875119 1.225 ENSMUST00000135406.1
ENSMUST00000114812.1
ENSMUST00000134616.1
ENSMUST00000023534.6
Golgb1


Golgb1
golgi autoantigen, golgin subfamily b, macrogolgin 1


golgi autoantigen, golgin subfamily b, macrogolgin 1
chrM_+_11734 1.031 ENSMUST00000082418.1
mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr7_-_127895578 0.964 ENSMUST00000033074.6
Vkorc1
vitamin K epoxide reductase complex, subunit 1
chr11_-_69695802 0.882 ENSMUST00000108649.1
ENSMUST00000174159.1
ENSMUST00000181810.1
BC096441

Tnfsf12
cDNA sequence BC096441

tumor necrosis factor (ligand) superfamily, member 12
chr12_+_84052114 0.819 ENSMUST00000120927.1
Acot3
acyl-CoA thioesterase 3
chr14_+_76476913 0.816 ENSMUST00000140251.2
Tsc22d1
TSC22 domain family, member 1
chr5_-_84417359 0.763 ENSMUST00000113401.1
Epha5
Eph receptor A5
chr12_-_78983476 0.756 ENSMUST00000070174.7
Tmem229b
transmembrane protein 229B
chr14_+_124005355 0.751 ENSMUST00000166105.1
Gm17615
predicted gene, 17615
chr3_-_95217877 0.742 ENSMUST00000136139.1
Gabpb2
GA repeat binding protein, beta 2
chr9_-_108263706 0.738 ENSMUST00000171412.1
Dag1
dystroglycan 1
chr2_+_175283298 0.686 ENSMUST00000098998.3
Gm14440
predicted gene 14440
chr19_+_3323301 0.649 ENSMUST00000025835.4
Cpt1a
carnitine palmitoyltransferase 1a, liver
chr4_-_19570073 0.647 ENSMUST00000029885.4
Cpne3
copine III

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.0 1.5 GO:0035567 non-canonical Wnt signaling pathway(GO:0035567)
0.2 1.3 GO:1903887 motile primary cilium assembly(GO:1903887) protein localization to ciliary transition zone(GO:1904491)
0.0 1.1 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.3 1.0 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.2 0.8 GO:0032788 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.1 0.8 GO:0032196 transposition(GO:0032196)
0.1 0.8 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.2 0.7 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.2 0.6 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.6 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.6 GO:0006862 nucleotide transport(GO:0006862)
0.1 0.5 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.5 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.1 0.4 GO:0034241 positive regulation of macrophage fusion(GO:0034241) regulation of osteoclast proliferation(GO:0090289)
0.1 0.4 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.4 GO:1902414 protein localization to cell junction(GO:1902414)
0.0 0.4 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.4 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 GO:0031527 filopodium membrane(GO:0031527)
0.1 1.3 GO:0036038 MKS complex(GO:0036038)
0.0 1.2 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.0 GO:0070469 respiratory chain(GO:0070469)
0.0 0.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 0.7 GO:0016011 dystroglycan complex(GO:0016011)
0.0 0.7 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.6 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.4 GO:0042555 MCM complex(GO:0042555)
0.0 0.4 GO:0043235 receptor complex(GO:0043235)
0.1 0.3 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0070545 PeBoW complex(GO:0070545)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 1.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 1.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.0 GO:0048038 quinone binding(GO:0048038)
0.1 0.8 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 0.8 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 0.7 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 0.6 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.0 0.6 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.0 0.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.5 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.4 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.4 GO:0015035 glutathione peroxidase activity(GO:0004602) protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.4 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 0.3 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.1 0.3 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.3 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 0.3 GO:0004454 ketohexokinase activity(GO:0004454)
0.0 0.3 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)