Motif ID: Alx4

Z-value: 0.669


Transcription factors associated with Alx4:

Gene SymbolEntrez IDGene Name
Alx4 ENSMUSG00000040310.6 Alx4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Alx4mm10_v2_chr2_+_93642307_936423880.154.9e-01Click!


Activity profile for motif Alx4.

activity profile for motif Alx4


Sorted Z-values histogram for motif Alx4

Sorted Z-values for motif Alx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Alx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_44121167 2.010 ENSMUST00000163056.1
ENSMUST00000159595.1
 Gm5083

predicted gene 5083

chr1_+_58210397 1.936 ENSMUST00000040442.5
 Aox4
aldehyde oxidase 4
chr10_+_97479470 1.864 ENSMUST00000105287.3
 Dcn
decorin
chrX_+_73483602 1.777 ENSMUST00000033741.8
ENSMUST00000169489.1
 Bgn

biglycan

chr6_-_136875794 1.672 ENSMUST00000032342.1
 Mgp
matrix Gla protein
chr7_-_46667375 1.639 ENSMUST00000107669.2
 Tph1
tryptophan hydroxylase 1
chr7_-_45103747 1.626 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr13_-_81710937 1.559 ENSMUST00000161920.1
ENSMUST00000048993.5
 Polr3g

polymerase (RNA) III (DNA directed) polypeptide G

chr5_+_13398688 1.492 ENSMUST00000125629.1
 Sema3a
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr1_-_163725123 1.447 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chrM_+_10167 1.302 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chrM_+_2743 1.291 ENSMUST00000082392.1
 mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr8_+_94152607 1.161 ENSMUST00000034211.8
 Mt3
metallothionein 3
chr15_+_9436028 1.156 ENSMUST00000042360.3
 Capsl
calcyphosine-like
chr9_-_123678873 1.154 ENSMUST00000040960.6
 Slc6a20a
solute carrier family 6 (neurotransmitter transporter), member 20A
chr2_-_160619971 1.137 ENSMUST00000109473.1
 Gm14221
predicted gene 14221
chr7_-_126676357 1.105 ENSMUST00000106371.1
ENSMUST00000106372.3
ENSMUST00000155419.1
 Sult1a1


sulfotransferase family 1A, phenol-preferring, member 1


chr2_+_91257323 1.096 ENSMUST00000111349.2
ENSMUST00000131711.1
 Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chrX_-_134111852 1.086 ENSMUST00000033610.6
 Nox1
NADPH oxidase 1
chr4_-_14621805 1.064 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.6 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.4 2.6 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.6 2.2 GO:0072592 oxygen metabolic process(GO:0072592)
0.4 2.2 GO:0036233 glycine import(GO:0036233)
0.2 2.1 GO:0051923 sulfation(GO:0051923)
0.6 1.9 GO:0046110 xanthine metabolic process(GO:0046110)
0.0 1.7 GO:0030500 regulation of bone mineralization(GO:0030500)
0.3 1.6 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 1.6 GO:0019882 antigen processing and presentation(GO:0019882)
0.3 1.5 GO:0021856 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.1 1.5 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 1.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 1.4 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.3 1.3 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 1.1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.3 1.0 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) olefin metabolic process(GO:1900673)
0.3 1.0 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.1 1.0 GO:0019532 oxalate transport(GO:0019532)
0.1 1.0 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0 1.0 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.0 GO:0031012 extracellular matrix(GO:0031012)
0.1 4.9 GO:0070469 respiratory chain(GO:0070469)
0.1 1.9 GO:0098644 complex of collagen trimers(GO:0098644)
0.1 1.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.4 GO:0043204 perikaryon(GO:0043204)
0.3 1.1 GO:0071438 NADPH oxidase complex(GO:0043020) invadopodium membrane(GO:0071438)
0.0 1.0 GO:0009986 cell surface(GO:0009986)
0.1 0.9 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.9 GO:0031594 neuromuscular junction(GO:0031594)
0.2 0.8 GO:0070820 tertiary granule(GO:0070820)
0.2 0.7 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.1 0.7 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.6 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.5 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.5 GO:0045171 intercellular bridge(GO:0045171)
0.1 0.4 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0 0.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.3 GO:0042585 germinal vesicle(GO:0042585)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 3.4 GO:0050840 extracellular matrix binding(GO:0050840)
0.9 2.6 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.4 2.2 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.7 2.1 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.5 1.9 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 1.9 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 1.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.5 1.6 GO:0019770 IgG receptor activity(GO:0019770)
0.3 1.5 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.1 1.5 GO:0038191 neuropilin binding(GO:0038191)
0.1 1.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.2 1.3 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.4 1.1 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 1.1 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 1.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.1 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 1.0 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 1.0 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 1.0 GO:0017134 fibroblast growth factor binding(GO:0017134)