Motif ID: Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Z-value: 0.713

Transcription factors associated with Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec:

Gene SymbolEntrez IDGene Name
Arntl ENSMUSG00000055116.7 Arntl
Mitf ENSMUSG00000035158.9 Mitf
Mlx ENSMUSG00000017801.9 Mlx
Mlxipl ENSMUSG00000005373.7 Mlxipl
Tfe3 ENSMUSG00000000134.11 Tfe3
Tfec ENSMUSG00000029553.7 Tfec

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mlxiplmm10_v2_chr5_+_135106881_135106918-0.511.3e-02Click!
Arntlmm10_v2_chr7_+_113207465_113207595-0.491.9e-02Click!
Mlxmm10_v2_chr11_+_101087277_1010873230.434.2e-02Click!
Tfe3mm10_v2_chrX_+_7762652_7762695-0.135.6e-01Click!
Mitfmm10_v2_chr6_+_97807014_97807067-0.077.3e-01Click!


Activity profile for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec.

activity profile for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec


Sorted Z-values histogram for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Sorted Z-values for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec



Network of associatons between targets according to the STRING database.



First level regulatory network of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_148039097 2.708 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr17_-_12769605 2.326 ENSMUST00000024599.7
 Igf2r
insulin-like growth factor 2 receptor
chr10_+_127063527 2.145 ENSMUST00000006911.5
 Cdk4
cyclin-dependent kinase 4
chr19_-_4201591 1.892 ENSMUST00000025740.6
 Rad9a
RAD9 homolog A
chr7_+_35802593 1.852 ENSMUST00000052454.2
 E130304I02Rik
RIKEN cDNA E130304I02 gene
chr4_-_41275091 1.788 ENSMUST00000030143.6
ENSMUST00000108068.1
 Ubap2

ubiquitin-associated protein 2

chr10_+_127063599 1.756 ENSMUST00000120226.1
ENSMUST00000133115.1
 Cdk4

cyclin-dependent kinase 4

chr8_+_13159135 1.728 ENSMUST00000033824.6
 Lamp1
lysosomal-associated membrane protein 1
chr2_+_92915080 1.723 ENSMUST00000028648.2
 Syt13
synaptotagmin XIII
chr10_-_18023229 1.630 ENSMUST00000020002.7
 Abracl
ABRA C-terminal like
chr4_+_148039035 1.619 ENSMUST00000097788.4
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr11_+_69991061 1.474 ENSMUST00000018711.8
 Gabarap
gamma-aminobutyric acid receptor associated protein
chr19_+_41981709 1.461 ENSMUST00000026170.1
 Ubtd1
ubiquitin domain containing 1
chr15_-_59374149 1.430 ENSMUST00000022976.4
 E430025E21Rik
RIKEN cDNA E430025E21 gene
chr7_+_121707189 1.375 ENSMUST00000065310.2
 1700069B07Rik
RIKEN cDNA 1700069B07 gene
chr6_-_90716489 1.353 ENSMUST00000101153.3
 Iqsec1
IQ motif and Sec7 domain 1
chr2_-_30286312 1.347 ENSMUST00000100219.3
 Dolk
dolichol kinase
chr10_+_4432467 1.302 ENSMUST00000095893.4
ENSMUST00000118544.1
ENSMUST00000117489.1
 1700052N19Rik


RIKEN cDNA 1700052N19 gene


chr10_-_19015347 1.286 ENSMUST00000019997.4
 Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr2_+_30286383 1.278 ENSMUST00000064447.5
 Nup188
nucleoporin 188

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 422 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 4.3 GO:0070829 heterochromatin maintenance(GO:0070829)
1.0 3.9 GO:0010288 response to lead ion(GO:0010288)
0.0 3.2 GO:0006405 RNA export from nucleus(GO:0006405)
0.0 3.2 GO:0032526 response to retinoic acid(GO:0032526)
0.3 2.7 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.7 2.1 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.1 2.1 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 2.0 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 1.7 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.3 1.6 GO:1904715 negative regulation of chaperone-mediated autophagy(GO:1904715)
0.2 1.6 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.1 1.6 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.3 1.5 GO:0040038 polar body extrusion after meiotic divisions(GO:0040038)
0.1 1.5 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.5 1.4 GO:0070428 regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.1 1.4 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.1 1.4 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 1.4 GO:0097284 hepatocyte apoptotic process(GO:0097284)
0.1 1.4 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.2 1.3 GO:0015808 L-alanine transport(GO:0015808)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 168 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 2.7 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.5 2.4 GO:0044611 nuclear pore inner ring(GO:0044611)
0.3 2.4 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 2.0 GO:0071203 WASH complex(GO:0071203)
0.0 2.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 2.0 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.6 1.9 GO:0044194 cytolytic granule(GO:0044194)
0.3 1.9 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 1.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.4 1.7 GO:0031084 BLOC-2 complex(GO:0031084)
0.1 1.7 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 1.7 GO:0000421 autophagosome membrane(GO:0000421)
0.0 1.7 GO:0031519 PcG protein complex(GO:0031519)
0.4 1.5 GO:0097413 Lewy body(GO:0097413)
0.4 1.3 GO:0033186 CAF-1 complex(GO:0033186)
0.2 1.1 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.0 1.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 1.0 GO:0001740 Barr body(GO:0001740)
0.1 1.0 GO:0042824 MHC class I peptide loading complex(GO:0042824)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 280 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.4 GO:0030332 cyclin binding(GO:0030332)
1.4 4.3 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 2.7 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.3 2.6 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 2.5 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.3 2.4 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.1 2.4 GO:0005123 death receptor binding(GO:0005123)
0.1 2.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 2.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 2.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.5 1.9 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 1.8 GO:0050811 GABA receptor binding(GO:0050811)
0.0 1.7 GO:0030276 clathrin binding(GO:0030276)
0.0 1.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.4 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.4 1.3 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.2 1.2 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.4 1.1 GO:0005436 sodium:phosphate symporter activity(GO:0005436) sodium:inorganic phosphate symporter activity(GO:0015319)
0.4 1.1 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.1 1.1 GO:0043008 ATP-dependent protein binding(GO:0043008)