Motif ID: Atf4

Z-value: 0.691


Transcription factors associated with Atf4:

Gene SymbolEntrez IDGene Name
Atf4 ENSMUSG00000042406.7 Atf4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf4mm10_v2_chr15_+_80255184_802552630.674.3e-04Click!


Activity profile for motif Atf4.

activity profile for motif Atf4


Sorted Z-values histogram for motif Atf4

Sorted Z-values for motif Atf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf4

PNG image of the network

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Top targets:


Showing 1 to 20 of 100 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 6.288 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr2_+_119351222 3.475 ENSMUST00000028780.3
 Chac1
ChaC, cation transport regulator 1
chr4_+_43957678 2.627 ENSMUST00000107855.1
 Glipr2
GLI pathogenesis-related 2
chr1_-_71653162 2.439 ENSMUST00000055226.6
 Fn1
fibronectin 1
chr19_-_12501996 1.061 ENSMUST00000045521.7
 Dtx4
deltex 4 homolog (Drosophila)
chr11_-_87826023 1.027 ENSMUST00000103177.3
 Lpo
lactoperoxidase
chr9_+_109931774 1.012 ENSMUST00000169851.2
 Map4
microtubule-associated protein 4
chr5_+_93093428 0.977 ENSMUST00000074733.7
 Sept11
septin 11
chr13_+_49682191 0.967 ENSMUST00000172254.1
 Iars
isoleucine-tRNA synthetase
chr11_+_100320596 0.916 ENSMUST00000152521.1
 Eif1
eukaryotic translation initiation factor 1
chr11_-_35798884 0.806 ENSMUST00000160726.2
 Fbll1
fibrillarin-like 1
chr2_-_18048784 0.783 ENSMUST00000142856.1
 Skida1
SKI/DACH domain containing 1
chrX_+_106187100 0.755 ENSMUST00000081593.6
 Pgk1
phosphoglycerate kinase 1
chr8_+_75093591 0.720 ENSMUST00000005548.6
 Hmox1
heme oxygenase (decycling) 1
chr3_-_138143352 0.696 ENSMUST00000098580.2
 Mttp
microsomal triglyceride transfer protein
chr13_+_49682100 0.688 ENSMUST00000165316.1
ENSMUST00000047363.7
 Iars

isoleucine-tRNA synthetase

chr2_-_18048347 0.640 ENSMUST00000066885.5
 Skida1
SKI/DACH domain containing 1
chr12_-_108893197 0.616 ENSMUST00000161154.1
ENSMUST00000161410.1
 Wars

tryptophanyl-tRNA synthetase

chr13_-_30545254 0.557 ENSMUST00000042834.3
 Uqcrfs1
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr4_-_129189600 0.556 ENSMUST00000117497.1
ENSMUST00000117350.1
 S100pbp

S100P binding protein


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 6.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 3.5 GO:0010955 negative regulation of protein processing(GO:0010955) negative regulation of protein maturation(GO:1903318)
0.0 2.6 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.8 2.4 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161)
0.6 1.7 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.2 1.4 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.3 1.0 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 0.9 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.2 0.8 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.0 0.8 GO:0030488 tRNA methylation(GO:0030488)
0.2 0.7 GO:1904706 response to cisplatin(GO:0072718) negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.1 0.7 GO:0051012 microtubule sliding(GO:0051012) negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.1 0.7 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 0.7 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.7 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.2 0.6 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.2 0.6 GO:0015960 diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
0.2 0.5 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.1 0.5 GO:0006545 glycine biosynthetic process(GO:0006545)
0.0 0.5 GO:0034501 protein localization to kinetochore(GO:0034501)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 GO:0005802 trans-Golgi network(GO:0005802)
0.8 2.4 GO:0005577 fibrinogen complex(GO:0005577)
0.0 2.4 GO:0000139 Golgi membrane(GO:0000139)
0.1 1.4 GO:0031430 M band(GO:0031430)
0.1 0.8 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.7 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.6 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 0.6 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.5 GO:0070552 BRISC complex(GO:0070552)
0.1 0.5 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.3 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.2 GO:0042382 paraspeckles(GO:0042382)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.1 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 3.5 GO:0005112 Notch binding(GO:0005112)
0.4 2.4 GO:0045340 mercury ion binding(GO:0045340)
0.6 1.7 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 1.6 GO:0043851 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA methyltransferase activity(GO:0008649) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) rRNA (uridine) methyltransferase activity(GO:0016436) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)
0.0 1.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 1.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 1.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 1.0 GO:0004601 peroxidase activity(GO:0004601)
0.2 0.7 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.0 0.7 GO:0034185 apolipoprotein binding(GO:0034185)
0.2 0.6 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.2 0.5 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.2 0.5 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.1 0.5 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 0.4 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.1 0.4 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 0.4 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.1 0.4 GO:0015375 glycine:sodium symporter activity(GO:0015375)