Motif ID: Atf6

Z-value: 0.801


Transcription factors associated with Atf6:

Gene SymbolEntrez IDGene Name
Atf6 ENSMUSG00000026663.6 Atf6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf6mm10_v2_chr1_-_170867761_1708677840.242.8e-01Click!


Activity profile for motif Atf6.

activity profile for motif Atf6


Sorted Z-values histogram for motif Atf6

Sorted Z-values for motif Atf6



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_23988852 4.638 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chrY_-_1245685 3.803 ENSMUST00000143286.1
ENSMUST00000137048.1
ENSMUST00000069309.7
ENSMUST00000139365.1
 Uty



ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome



chr8_+_125995102 3.700 ENSMUST00000046765.8
 Kcnk1
potassium channel, subfamily K, member 1
chr5_+_134986191 3.608 ENSMUST00000094245.2
 Cldn3
claudin 3
chr6_-_101377897 3.533 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chrX_+_41401128 2.783 ENSMUST00000115103.2
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chrY_-_1245753 2.415 ENSMUST00000154004.1
 Uty
ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
chr12_+_82616885 2.344 ENSMUST00000161801.1
 Rgs6
regulator of G-protein signaling 6
chr3_+_104638658 2.148 ENSMUST00000046212.1
 Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr5_-_89883321 2.011 ENSMUST00000163159.1
ENSMUST00000061427.5
 Adamts3

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3

chr16_+_41532999 1.993 ENSMUST00000099761.3
 Lsamp
limbic system-associated membrane protein
chr15_-_77956658 1.837 ENSMUST00000117725.1
ENSMUST00000016696.6
 Foxred2

FAD-dependent oxidoreductase domain containing 2

chr4_+_88094599 1.743 ENSMUST00000097992.3
 Focad
focadhesin
chr13_-_105054895 1.547 ENSMUST00000063551.5
 Rgs7bp
regulator of G-protein signalling 7 binding protein
chr5_+_35056813 1.546 ENSMUST00000101298.2
ENSMUST00000114270.1
ENSMUST00000133381.1
 Dok7


docking protein 7


chr4_-_149774238 1.432 ENSMUST00000105686.2
 Slc25a33
solute carrier family 25, member 33
chr7_-_45092130 1.379 ENSMUST00000148175.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr4_+_125490688 1.299 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr1_-_55226768 1.287 ENSMUST00000027121.8
ENSMUST00000114428.2
 Rftn2

raftlin family member 2

chr6_-_136173492 1.272 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 119 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.6 GO:0007528 neuromuscular junction development(GO:0007528)
0.7 5.7 GO:0071557 histone H3-K27 demethylation(GO:0071557)
1.5 4.6 GO:0043379 memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.8 3.8 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.5 3.6 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 3.2 GO:0001919 regulation of receptor recycling(GO:0001919)
0.1 2.8 GO:0035641 locomotory exploration behavior(GO:0035641)
0.1 2.1 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0 2.1 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.4 2.0 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 1.7 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.5 1.4 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.1 1.4 GO:0014049 positive regulation of glutamate secretion(GO:0014049)
0.2 1.3 GO:0032596 protein transport into membrane raft(GO:0032596) dsRNA transport(GO:0033227)
0.2 1.2 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0 1.2 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094)
0.4 1.1 GO:0072223 metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.1 1.1 GO:0032808 lacrimal gland development(GO:0032808)
0.3 1.0 GO:0009405 pathogenesis(GO:0009405)
0.1 1.0 GO:0071569 protein ufmylation(GO:0071569)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.8 GO:0031594 neuromuscular junction(GO:0031594)
0.1 5.2 GO:0005657 replication fork(GO:0005657)
0.4 4.1 GO:0043083 synaptic cleft(GO:0043083)
0.1 3.7 GO:0031526 brush border membrane(GO:0031526)
0.2 3.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 2.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 2.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.4 GO:0030667 secretory granule membrane(GO:0030667)
0.2 1.3 GO:0005827 polar microtubule(GO:0005827)
0.1 1.2 GO:0031527 filopodium membrane(GO:0031527)
0.2 1.1 GO:0030314 junctional membrane complex(GO:0030314)
0.0 1.0 GO:0031201 SNARE complex(GO:0031201)
0.0 0.9 GO:0016528 sarcoplasm(GO:0016528)
0.1 0.8 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 0.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.7 GO:0043196 varicosity(GO:0043196)
0.0 0.7 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.7 GO:0030173 integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 5.7 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.4 4.6 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 4.3 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.3 3.8 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.4 2.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 2.8 GO:0005158 insulin receptor binding(GO:0005158)
0.1 2.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 1.8 GO:0004497 monooxygenase activity(GO:0004497)
0.0 1.7 GO:0019210 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.1 1.4 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.3 1.3 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.1 1.3 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 1.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 1.3 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 1.2 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 1.1 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 1.0 GO:0015643 toxic substance binding(GO:0015643)
0.0 1.0 GO:0017022 myosin binding(GO:0017022)
0.2 0.9 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)