Motif ID: Brca1

Z-value: 0.541


Transcription factors associated with Brca1:

Gene SymbolEntrez IDGene Name
Brca1 ENSMUSG00000017146.6 Brca1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Brca1mm10_v2_chr11_-_101551837_1015518930.184.2e-01Click!


Activity profile for motif Brca1.

activity profile for motif Brca1


Sorted Z-values histogram for motif Brca1

Sorted Z-values for motif Brca1



Network of associatons between targets according to the STRING database.



First level regulatory network of Brca1

PNG image of the network

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Top targets:


Showing 1 to 20 of 177 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 7.460 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr11_+_44617310 2.098 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
Ebf1


early B cell factor 1


chr1_-_75278345 1.918 ENSMUST00000039534.4
Resp18
regulated endocrine-specific protein 18
chr18_-_47333311 1.681 ENSMUST00000126684.1
ENSMUST00000156422.1
Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr7_-_144939823 1.380 ENSMUST00000093962.4
Ccnd1
cyclin D1
chr11_+_97415527 1.372 ENSMUST00000121799.1
Arhgap23
Rho GTPase activating protein 23
chr8_-_47990535 1.228 ENSMUST00000057561.7
Wwc2
WW, C2 and coiled-coil domain containing 2
chr16_-_16829276 1.023 ENSMUST00000023468.5
Spag6
sperm associated antigen 6
chr6_+_14901344 1.016 ENSMUST00000115477.1
Foxp2
forkhead box P2
chr11_-_106998483 0.987 ENSMUST00000124541.1
Kpna2
karyopherin (importin) alpha 2
chr10_-_33624587 0.904 ENSMUST00000160299.1
ENSMUST00000019920.6
Clvs2

clavesin 2

chr16_+_44394771 0.860 ENSMUST00000099742.2
Wdr52
WD repeat domain 52
chr1_+_66386968 0.822 ENSMUST00000145419.1
Map2
microtubule-associated protein 2
chr14_-_67715585 0.790 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
Cdca2


cell division cycle associated 2


chr2_-_28916668 0.711 ENSMUST00000113847.1
Barhl1
BarH-like 1 (Drosophila)
chr9_-_109082372 0.704 ENSMUST00000167504.1
Tma7
translational machinery associated 7 homolog (S. cerevisiae)
chr13_-_49320219 0.680 ENSMUST00000110086.1
Fgd3
FYVE, RhoGEF and PH domain containing 3
chr1_+_74791516 0.663 ENSMUST00000006718.8
Wnt10a
wingless related MMTV integration site 10a
chr4_+_86053887 0.656 ENSMUST00000107178.2
ENSMUST00000048885.5
ENSMUST00000141889.1
ENSMUST00000120678.1
Adamtsl1



ADAMTS-like 1



chr11_-_98625661 0.649 ENSMUST00000104933.1
Gm12355
predicted gene 12355

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 7.5 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 1.7 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.2 1.4 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.2 1.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 1.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 1.0 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 1.0 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.9 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.9 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.1 0.7 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.7 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.2 0.6 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.2 0.6 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.1 0.6 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.1 0.6 GO:0044829 negative regulation by host of viral genome replication(GO:0044828) positive regulation by host of viral genome replication(GO:0044829)
0.0 0.6 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.6 GO:0072643 interferon-gamma secretion(GO:0072643)
0.0 0.6 GO:0030901 midbrain development(GO:0030901)
0.1 0.5 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.1 0.5 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.9 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 1.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.2 GO:0005643 nuclear pore(GO:0005643)
0.0 0.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 0.7 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.2 0.6 GO:0044194 cytolytic granule(GO:0044194)
0.1 0.6 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.5 GO:0000125 PCAF complex(GO:0000125)
0.1 0.5 GO:0042382 paraspeckles(GO:0042382)
0.0 0.5 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.5 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.4 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.4 GO:0005921 gap junction(GO:0005921)
0.1 0.3 GO:0032437 cuticular plate(GO:0032437)
0.0 0.3 GO:0030677 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0 0.3 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.2 2.6 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.1 2.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 1.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 1.4 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.0 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.9 GO:0005109 frizzled binding(GO:0005109)
0.1 0.8 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.7 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 0.6 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.6 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.6 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.6 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.2 0.5 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.1 0.5 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.5 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.0 0.5 GO:1990405 protein antigen binding(GO:1990405)
0.0 0.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)