Motif ID: Clock

Z-value: 0.504


Transcription factors associated with Clock:

Gene SymbolEntrez IDGene Name
Clock ENSMUSG00000029238.8 Clock

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Clockmm10_v2_chr5_-_76304474_76304548-0.039.0e-01Click!


Activity profile for motif Clock.

activity profile for motif Clock


Sorted Z-values histogram for motif Clock

Sorted Z-values for motif Clock



Network of associatons between targets according to the STRING database.



First level regulatory network of Clock

PNG image of the network

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Top targets:


Showing 1 to 20 of 153 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 1.545 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr7_-_144939823 1.288 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr6_-_49214954 1.251 ENSMUST00000031838.7
 Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr2_+_164769892 0.998 ENSMUST00000088248.6
ENSMUST00000001439.6
 Ube2c

ubiquitin-conjugating enzyme E2C

chr1_-_75219245 0.874 ENSMUST00000079464.6
 Tuba4a
tubulin, alpha 4A
chr8_+_58912257 0.848 ENSMUST00000160055.1
 BC030500
cDNA sequence BC030500
chr11_+_101316200 0.847 ENSMUST00000142640.1
ENSMUST00000019470.7
 Psme3

proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)

chr5_+_93093428 0.752 ENSMUST00000074733.7
 Sept11
septin 11
chr11_-_100759942 0.744 ENSMUST00000107363.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr7_-_68749170 0.744 ENSMUST00000118110.1
ENSMUST00000048068.7
 Arrdc4

arrestin domain containing 4

chr1_-_12991109 0.722 ENSMUST00000115403.2
ENSMUST00000115402.1
 Slco5a1

solute carrier organic anion transporter family, member 5A1

chr9_-_121495678 0.660 ENSMUST00000035120.4
 Cck
cholecystokinin
chr14_-_20181773 0.649 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr11_-_100759740 0.625 ENSMUST00000107361.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr2_+_83644435 0.623 ENSMUST00000081591.6
 Zc3h15
zinc finger CCCH-type containing 15
chr5_-_22344690 0.597 ENSMUST00000062372.7
ENSMUST00000161356.1
 Reln

reelin

chr5_+_146231211 0.590 ENSMUST00000161181.1
ENSMUST00000161652.1
ENSMUST00000031640.8
ENSMUST00000159467.1
 Cdk8



cyclin-dependent kinase 8



chr2_+_160645881 0.585 ENSMUST00000109468.2
 Top1
topoisomerase (DNA) I
chr12_+_59131473 0.585 ENSMUST00000177162.1
 Ctage5
CTAGE family, member 5
chr4_-_97778042 0.576 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.5 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 1.4 GO:0010950 positive regulation of endopeptidase activity(GO:0010950)
0.2 1.3 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.2 1.2 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.2 1.0 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.1 0.7 GO:0048254 snoRNA localization(GO:0048254)
0.1 0.7 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.1 0.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.7 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.2 0.6 GO:1903334 positive regulation of protein folding(GO:1903334)
0.1 0.6 GO:0097477 lateral motor column neuron migration(GO:0097477)
0.1 0.6 GO:0090209 negative regulation of triglyceride metabolic process(GO:0090209)
0.1 0.6 GO:0006265 DNA topological change(GO:0006265)
0.1 0.6 GO:0030322 stabilization of membrane potential(GO:0030322)
0.2 0.5 GO:0002014 vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014)
0.1 0.5 GO:0006543 glutamine catabolic process(GO:0006543)
0.1 0.5 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.5 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.1 0.4 GO:0002842 T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) positive regulation of T cell mediated immune response to tumor cell(GO:0002842)
0.1 0.4 GO:0060437 lung growth(GO:0060437)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.4 GO:0008537 proteasome activator complex(GO:0008537)
0.0 1.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 0.8 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.7 GO:0043203 axon hillock(GO:0043203)
0.1 0.6 GO:0001651 dense fibrillar component(GO:0001651)
0.1 0.6 GO:0000125 PCAF complex(GO:0000125)
0.0 0.6 GO:0016592 mediator complex(GO:0016592)
0.1 0.5 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.5 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 0.4 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1 0.4 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 0.4 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 0.4 GO:0031527 filopodium membrane(GO:0031527)
0.1 0.3 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.3 GO:0032797 SMN complex(GO:0032797)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 1.4 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 1.4 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.4 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 1.3 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 1.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.9 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.2 0.8 GO:0035851 histone deacetylase activity (H4-K16 specific)(GO:0034739) Krueppel-associated box domain binding(GO:0035851)
0.0 0.8 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.7 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.1 0.7 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.6 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.1 0.6 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.1 0.6 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.5 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.5 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 0.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.5 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 0.4 GO:0004998 transferrin receptor activity(GO:0004998)