Motif ID: Cux1

Z-value: 0.629


Transcription factors associated with Cux1:

Gene SymbolEntrez IDGene Name
Cux1 ENSMUSG00000029705.11 Cux1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cux1mm10_v2_chr5_-_136567242_1365672870.424.6e-02Click!


Activity profile for motif Cux1.

activity profile for motif Cux1


Sorted Z-values histogram for motif Cux1

Sorted Z-values for motif Cux1



Network of associatons between targets according to the STRING database.



First level regulatory network of Cux1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_78499087 3.492 ENSMUST00000017488.4
Vtn
vitronectin
chr7_-_103827922 2.762 ENSMUST00000023934.6
ENSMUST00000153218.1
Hbb-bs

hemoglobin, beta adult s chain

chr5_+_117841839 2.175 ENSMUST00000142742.2
Nos1
nitric oxide synthase 1, neuronal
chr2_+_71528657 1.595 ENSMUST00000126400.1
Dlx1
distal-less homeobox 1
chr2_+_71529085 1.516 ENSMUST00000152711.1
Dlx1
distal-less homeobox 1
chr17_-_6782775 1.153 ENSMUST00000064234.6
Ezr
ezrin
chr4_+_119814495 1.062 ENSMUST00000106307.2
Hivep3
human immunodeficiency virus type I enhancer binding protein 3
chr7_+_96210107 1.024 ENSMUST00000138760.1
Tenm4
teneurin transmembrane protein 4
chr5_-_122050102 1.003 ENSMUST00000154139.1
Cux2
cut-like homeobox 2
chr7_-_19698383 0.863 ENSMUST00000173739.1
Apoe
apolipoprotein E
chrX_+_7722214 0.807 ENSMUST00000043045.2
ENSMUST00000116634.1
ENSMUST00000115689.3
ENSMUST00000131077.1
ENSMUST00000115688.1
ENSMUST00000116633.1
Wdr45





WD repeat domain 45





chr10_-_117282262 0.800 ENSMUST00000092163.7
Lyz2
lysozyme 2
chrX_+_7722267 0.785 ENSMUST00000125991.1
ENSMUST00000148624.1
Wdr45

WD repeat domain 45

chr9_-_40346290 0.781 ENSMUST00000121357.1
Gramd1b
GRAM domain containing 1B
chr5_-_70842617 0.772 ENSMUST00000031119.1
Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr3_-_85722474 0.748 ENSMUST00000119077.1
Fam160a1
family with sequence similarity 160, member A1
chr7_-_19698206 0.748 ENSMUST00000172808.1
ENSMUST00000174191.1
Apoe

apolipoprotein E

chr5_+_66968559 0.738 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1
chr16_-_91597636 0.692 ENSMUST00000023686.8
Tmem50b
transmembrane protein 50B
chr2_+_22622183 0.659 ENSMUST00000028123.3
Gad2
glutamic acid decarboxylase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.5 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
1.0 3.1 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
0.5 2.2 GO:1901204 positive regulation of guanylate cyclase activity(GO:0031284) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
0.5 1.6 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.1 1.6 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.4 1.2 GO:1900041 intestinal D-glucose absorption(GO:0001951) negative regulation of interleukin-2 secretion(GO:1900041) terminal web assembly(GO:1902896)
0.3 1.0 GO:0032289 central nervous system myelin formation(GO:0032289)
0.1 1.0 GO:0071569 protein ufmylation(GO:0071569)
0.0 1.0 GO:0007614 short-term memory(GO:0007614)
0.0 0.9 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.1 0.8 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 0.8 GO:0019835 cytolysis(GO:0019835)
0.0 0.8 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.8 GO:0022904 respiratory electron transport chain(GO:0022904)
0.0 0.7 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.0 0.7 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.1 0.6 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.1 0.6 GO:0006538 glutamate catabolic process(GO:0006538)
0.1 0.6 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.1 0.6 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 4.3 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.7 2.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 2.3 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.5 1.6 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 1.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 1.3 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.3 1.2 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 1.1 GO:0005604 basement membrane(GO:0005604)
0.0 0.8 GO:0009925 basal plasma membrane(GO:0009925)
0.2 0.7 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 0.7 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.5 GO:0042627 chylomicron(GO:0042627)
0.1 0.5 GO:0044316 cone cell pedicle(GO:0044316)
0.0 0.5 GO:0030312 external encapsulating structure(GO:0030312)
0.0 0.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.4 GO:0033391 chromatoid body(GO:0033391)
0.0 0.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.4 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.4 GO:0055038 recycling endosome membrane(GO:0055038)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.5 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.7 2.8 GO:0031720 haptoglobin binding(GO:0031720)
0.7 2.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.5 1.6 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.1 1.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 1.3 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 1.2 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.8 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 0.7 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.1 0.7 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 0.7 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.7 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 0.6 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.1 0.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.2 0.5 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.2 0.5 GO:0004658 propionyl-CoA carboxylase activity(GO:0004658)
0.1 0.5 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)