Motif ID: Cxxc1

Z-value: 0.475


Transcription factors associated with Cxxc1:

Gene SymbolEntrez IDGene Name
Cxxc1 ENSMUSG00000024560.6 Cxxc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cxxc1mm10_v2_chr18_+_74216118_74216145-0.674.1e-04Click!


Activity profile for motif Cxxc1.

activity profile for motif Cxxc1


Sorted Z-values histogram for motif Cxxc1

Sorted Z-values for motif Cxxc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Cxxc1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_97415527 2.230 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr7_-_49636847 2.138 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr10_+_50895651 1.677 ENSMUST00000020071.3
 Sim1
single-minded homolog 1 (Drosophila)
chr11_-_89302545 1.148 ENSMUST00000061728.3
 Nog
noggin
chr5_+_30588078 0.738 ENSMUST00000066295.2
 Kcnk3
potassium channel, subfamily K, member 3
chr11_-_69921057 0.701 ENSMUST00000108609.1
ENSMUST00000108608.1
ENSMUST00000164359.1
 Eif5a


eukaryotic translation initiation factor 5A


chr11_-_69920892 0.670 ENSMUST00000152589.1
ENSMUST00000108612.1
ENSMUST00000108611.1
 Eif5a


eukaryotic translation initiation factor 5A


chr5_-_4758216 0.629 ENSMUST00000054294.4
 Fzd1
frizzled homolog 1 (Drosophila)
chr3_-_8964037 0.580 ENSMUST00000091354.5
ENSMUST00000094381.4
 Tpd52

tumor protein D52

chr10_+_128058974 0.540 ENSMUST00000084771.2
 Ptges3
prostaglandin E synthase 3 (cytosolic)
chr5_-_125389177 0.529 ENSMUST00000108707.2
 Ubc
ubiquitin C
chr10_+_128058947 0.509 ENSMUST00000052798.7
 Ptges3
prostaglandin E synthase 3 (cytosolic)
chr11_-_69920581 0.491 ENSMUST00000108610.1
 Eif5a
eukaryotic translation initiation factor 5A
chr10_+_85928491 0.478 ENSMUST00000170396.1
 Ascl4
achaete-scute complex homolog 4 (Drosophila)
chr17_-_14203695 0.457 ENSMUST00000053218.5
 Dact2
dapper homolog 2, antagonist of beta-catenin (xenopus)
chr1_-_124045523 0.435 ENSMUST00000112606.1
 Dpp10
dipeptidylpeptidase 10
chr10_-_79766872 0.409 ENSMUST00000047203.8
 Rnf126
ring finger protein 126
chrX_-_158043266 0.406 ENSMUST00000026750.8
ENSMUST00000112513.1
 Cnksr2

connector enhancer of kinase suppressor of Ras 2

chr11_+_71019593 0.363 ENSMUST00000133413.1
ENSMUST00000164220.1
ENSMUST00000048807.5
 Mis12


MIS12 homolog (yeast)


chr8_+_70594466 0.355 ENSMUST00000019283.9
 Isyna1
myo-inositol 1-phosphate synthase A1
chr2_+_112239468 0.347 ENSMUST00000028554.3
 Lpcat4
lysophosphatidylcholine acyltransferase 4
chr8_-_122443404 0.334 ENSMUST00000006692.4
 Mvd
mevalonate (diphospho) decarboxylase
chr1_-_124045247 0.330 ENSMUST00000112603.2
 Dpp10
dipeptidylpeptidase 10
chr18_-_43477764 0.302 ENSMUST00000057110.9
 Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr5_-_125389915 0.293 ENSMUST00000136312.1
 Ubc
ubiquitin C
chrX_+_53607918 0.292 ENSMUST00000114827.1
 Cxx1c
CAAX box 1C
chr9_-_106789130 0.286 ENSMUST00000046502.5
 Rad54l2
RAD54 like 2 (S. cerevisiae)
chrX_+_53607987 0.274 ENSMUST00000063384.3
ENSMUST00000169626.1
 Cxx1c

CAAX box 1C

chr5_-_65391380 0.272 ENSMUST00000120094.1
ENSMUST00000118543.1
ENSMUST00000127874.1
 Rpl9


ribosomal protein L9


chr5_+_125389284 0.269 ENSMUST00000100700.2
 Gm10382
predicted gene 10382
chr11_+_80383279 0.261 ENSMUST00000165565.1
ENSMUST00000017567.7
 Zfp207

zinc finger protein 207

chr19_-_19111181 0.251 ENSMUST00000112832.1
 Rorb
RAR-related orphan receptor beta
chr5_-_65391408 0.243 ENSMUST00000057885.6
 Rpl9
ribosomal protein L9
chr8_+_92357787 0.214 ENSMUST00000034184.10
 Irx5
Iroquois related homeobox 5 (Drosophila)
chr12_-_54656496 0.214 ENSMUST00000056228.6
 Sptssa
serine palmitoyltransferase, small subunit A
chr7_+_128744870 0.194 ENSMUST00000042942.8
 Sec23ip
Sec23 interacting protein
chr5_-_45857473 0.188 ENSMUST00000016026.7
ENSMUST00000067997.6
ENSMUST00000045586.6
 Lcorl


ligand dependent nuclear receptor corepressor-like


chr5_+_143403819 0.176 ENSMUST00000110731.2
 Kdelr2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr11_+_32205411 0.151 ENSMUST00000039601.3
ENSMUST00000149043.1
 Snrnp25

small nuclear ribonucleoprotein 25 (U11/U12)

chr11_+_32205483 0.132 ENSMUST00000121182.1
 Snrnp25
small nuclear ribonucleoprotein 25 (U11/U12)
chr12_-_82496537 0.118 ENSMUST00000179295.1
 Gm5435
predicted gene 5435
chr10_+_80249441 0.116 ENSMUST00000020361.6
 Ndufs7
NADH dehydrogenase (ubiquinone) Fe-S protein 7
chr15_-_77153772 0.112 ENSMUST00000166610.1
ENSMUST00000111581.2
 Rbfox2

RNA binding protein, fox-1 homolog (C. elegans) 2

chr3_-_101307079 0.105 ENSMUST00000097146.2
 Gm10355
predicted gene 10355
chrX_+_48623737 0.083 ENSMUST00000114936.1
 Slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr15_+_74516196 0.062 ENSMUST00000042035.9
 Bai1
brain-specific angiogenesis inhibitor 1
chr4_+_109000770 0.054 ENSMUST00000106644.2
 Nrd1
nardilysin, N-arginine dibasic convertase, NRD convertase 1
chr4_+_109000606 0.047 ENSMUST00000065977.4
ENSMUST00000102736.2
 Nrd1

nardilysin, N-arginine dibasic convertase, NRD convertase 1

chr10_-_7681118 0.041 ENSMUST00000159977.1
ENSMUST00000162682.1
 Pcmt1

protein-L-isoaspartate (D-aspartate) O-methyltransferase 1

chr1_-_180813534 0.036 ENSMUST00000159789.1
ENSMUST00000081026.4
 H3f3a

H3 histone, family 3A

chrX_-_7375830 0.010 ENSMUST00000115744.1
 Usp27x
ubiquitin specific peptidase 27, X chromosome
chr11_+_60537978 0.006 ENSMUST00000044250.3
 Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr12_+_110279228 0.003 ENSMUST00000097228.4
 Dio3
deiodinase, iodothyronine type III

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.9 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.3 1.1 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.2 0.6 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.1 2.1 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 1.0 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 0.5 GO:0072061 inner medullary collecting duct development(GO:0072061)
0.1 0.3 GO:0019287 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.1 0.8 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.1 0.7 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.3 GO:0046549 retinal cone cell development(GO:0046549)
0.0 0.2 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.4 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.4 GO:0071218 cellular response to misfolded protein(GO:0071218)
0.0 0.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.4 GO:0051382 protein localization to kinetochore(GO:0034501) kinetochore assembly(GO:0051382)
0.0 0.1 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.2 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.8 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.0 0.8 GO:0002181 cytoplasmic translation(GO:0002181)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.9 GO:0005642 annulate lamellae(GO:0005642)
0.1 0.3 GO:1990047 spindle matrix(GO:1990047)
0.1 0.4 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 1.0 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.2 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.3 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.2 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.3 GO:0005689 U12-type spliceosomal complex(GO:0005689)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 1.9 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 0.8 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.3 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.1 0.3 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 0.2 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758)
0.1 0.7 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.2 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.5 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.1 GO:0019955 cytokine binding(GO:0019955)
0.0 0.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)