Motif ID: Dlx1

Z-value: 0.910


Transcription factors associated with Dlx1:

Gene SymbolEntrez IDGene Name
Dlx1 ENSMUSG00000041911.3 Dlx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx1mm10_v2_chr2_+_71529085_715291100.683.2e-04Click!


Activity profile for motif Dlx1.

activity profile for motif Dlx1


Sorted Z-values histogram for motif Dlx1

Sorted Z-values for motif Dlx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Dlx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_101377897 3.936 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr15_-_8710734 3.575 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr12_+_84069325 3.459 ENSMUST00000046422.4
ENSMUST00000072505.4
 Acot5

acyl-CoA thioesterase 5

chr11_-_98053415 2.722 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chr3_+_66219909 2.517 ENSMUST00000029421.5
 Ptx3
pentraxin related gene
chr15_-_8710409 2.482 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_+_58210397 2.472 ENSMUST00000040442.5
 Aox4
aldehyde oxidase 4
chr13_+_94083490 2.412 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr6_-_36811361 2.398 ENSMUST00000101534.1
 Ptn
pleiotrophin
chr14_+_80000292 2.174 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr2_+_116067213 2.124 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr11_+_114675431 2.086 ENSMUST00000045779.5
 Ttyh2
tweety homolog 2 (Drosophila)
chr7_-_45103747 2.016 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chrX_+_150547375 1.991 ENSMUST00000066337.6
ENSMUST00000112715.1
 Alas2

aminolevulinic acid synthase 2, erythroid

chr5_+_107403496 1.756 ENSMUST00000049146.5
 Ephx4
epoxide hydrolase 4
chr5_-_70842617 1.700 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr16_+_43247278 1.631 ENSMUST00000114691.1
ENSMUST00000079441.6
 Zbtb20

zinc finger and BTB domain containing 20

chr8_+_94152607 1.585 ENSMUST00000034211.8
 Mt3
metallothionein 3
chr6_-_137169710 1.558 ENSMUST00000117919.1
 Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr6_+_30541582 1.557 ENSMUST00000096066.4
 Cpa2
carboxypeptidase A2, pancreatic

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 129 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 6.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 3.9 GO:0007528 neuromuscular junction development(GO:0007528)
0.9 3.5 GO:0032788 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.8 2.5 GO:0008228 opsonization(GO:0008228) modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.8 2.5 GO:0046110 xanthine metabolic process(GO:0046110)
0.8 2.4 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.0 2.4 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.1 2.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 2.2 GO:0006821 chloride transport(GO:0006821)
0.1 2.0 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.3 1.8 GO:0036233 glycine import(GO:0036233)
0.5 1.6 GO:0097212 lysosomal membrane organization(GO:0097212)
0.0 1.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 1.6 GO:0019882 antigen processing and presentation(GO:0019882)
0.1 1.5 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 1.5 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 1.5 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.1 1.4 GO:0051923 sulfation(GO:0051923)
0.4 1.3 GO:2000040 regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.3 1.3 GO:0006538 glutamate catabolic process(GO:0006538)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.0 GO:0031594 neuromuscular junction(GO:0031594)
0.4 6.1 GO:0043205 fibril(GO:0043205)
0.0 3.0 GO:0070469 respiratory chain(GO:0070469)
0.1 2.3 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.2 2.2 GO:0042581 specific granule(GO:0042581)
0.1 2.1 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.5 GO:0016607 nuclear speck(GO:0016607)
0.1 1.3 GO:0060077 inhibitory synapse(GO:0060077)
0.2 1.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.0 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 1.0 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 1.0 GO:0031901 early endosome membrane(GO:0031901)
0.1 0.9 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.7 GO:0030061 mitochondrial crista(GO:0030061)
0.1 0.7 GO:0072372 primary cilium(GO:0072372)
0.0 0.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.7 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 0.6 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.6 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 5.9 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1 3.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 3.6 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.2 2.8 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.6 2.5 GO:0030151 molybdenum ion binding(GO:0030151)
0.5 2.5 GO:0001849 complement component C1q binding(GO:0001849)
0.8 2.4 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 2.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 2.3 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 2.2 GO:0045296 cadherin binding(GO:0045296)
0.0 2.1 GO:0008276 protein methyltransferase activity(GO:0008276)
0.7 2.0 GO:0019770 IgG receptor activity(GO:0019770)
0.1 2.0 GO:0016594 glycine binding(GO:0016594)
0.3 1.8 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 1.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.5 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.5 1.4 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.1 1.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 1.3 GO:0004351 glutamate decarboxylase activity(GO:0004351)