Motif ID: Dlx5_Dlx4

Z-value: 1.225

Transcription factors associated with Dlx5_Dlx4:

Gene SymbolEntrez IDGene Name
Dlx4 ENSMUSG00000020871.7 Dlx4
Dlx5 ENSMUSG00000029755.9 Dlx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx5mm10_v2_chr6_-_6882068_6882092-0.612.2e-03Click!


Activity profile for motif Dlx5_Dlx4.

activity profile for motif Dlx5_Dlx4


Sorted Z-values histogram for motif Dlx5_Dlx4

Sorted Z-values for motif Dlx5_Dlx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Dlx5_Dlx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 9.524 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr3_+_55782500 5.780 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr9_-_16378231 4.217 ENSMUST00000082170.5
 Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chr8_-_57653023 3.333 ENSMUST00000034021.5
 Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr1_+_6487231 3.235 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr3_+_146121655 3.049 ENSMUST00000039450.4
 Mcoln3
mucolipin 3
chr6_-_50456085 2.577 ENSMUST00000146341.1
ENSMUST00000071728.4
 Osbpl3

oxysterol binding protein-like 3

chr12_-_55014329 2.494 ENSMUST00000172875.1
 Baz1a
bromodomain adjacent to zinc finger domain 1A
chr6_+_8948608 2.452 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr9_-_66514567 2.447 ENSMUST00000056890.8
 Fbxl22
F-box and leucine-rich repeat protein 22
chr16_+_52031549 2.351 ENSMUST00000114471.1
 Cblb
Casitas B-lineage lymphoma b
chr17_+_29090969 2.315 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr8_-_4779513 2.152 ENSMUST00000022945.7
 Shcbp1
Shc SH2-domain binding protein 1
chr7_-_62464505 2.137 ENSMUST00000094339.2
 Peg12
paternally expressed 12
chr17_+_34039437 2.040 ENSMUST00000131134.1
ENSMUST00000087497.4
ENSMUST00000114255.1
ENSMUST00000114252.1
 Col11a2



collagen, type XI, alpha 2



chr1_-_126738167 1.937 ENSMUST00000160693.1
 Nckap5
NCK-associated protein 5
chr2_-_121235689 1.936 ENSMUST00000142400.1
 Trp53bp1
transformation related protein 53 binding protein 1
chrX_-_60893430 1.897 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr4_+_13743424 1.868 ENSMUST00000006761.3
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr2_+_165655237 1.785 ENSMUST00000063433.7
 Eya2
eyes absent 2 homolog (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 205 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 9.8 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.2 4.2 GO:0010842 retina layer formation(GO:0010842)
0.1 3.9 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.2 3.6 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1 3.0 GO:0042491 auditory receptor cell differentiation(GO:0042491)
0.3 2.9 GO:0090399 replicative senescence(GO:0090399)
0.1 2.9 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 2.6 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.8 2.4 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.1 2.4 GO:0000578 embryonic axis specification(GO:0000578)
0.0 2.4 GO:0006338 chromatin remodeling(GO:0006338)
0.1 2.2 GO:0008347 glial cell migration(GO:0008347)
0.5 2.1 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.7 2.0 GO:0060023 soft palate development(GO:0060023)
0.1 1.9 GO:0007530 sex determination(GO:0007530)
0.3 1.8 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 1.8 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.0 1.7 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.3 1.6 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.2 1.6 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 GO:0035371 microtubule plus-end(GO:0035371)
0.0 3.8 GO:0060076 excitatory synapse(GO:0060076)
0.1 3.7 GO:0043034 costamere(GO:0043034)
0.0 3.2 GO:0005657 replication fork(GO:0005657)
0.1 3.1 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 2.9 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 2.7 GO:0005814 centriole(GO:0005814)
0.5 2.5 GO:0008623 CHRAC(GO:0008623)
0.8 2.3 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 2.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.2 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 2.1 GO:0043195 terminal bouton(GO:0043195)
0.4 1.5 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.3 1.3 GO:0036449 microtubule minus-end(GO:0036449)
0.2 1.3 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 1.3 GO:0060077 inhibitory synapse(GO:0060077)
0.1 1.1 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.1 GO:0030175 filopodium(GO:0030175)
0.1 1.0 GO:0042382 paraspeckles(GO:0042382)
0.0 1.0 GO:0000792 heterochromatin(GO:0000792)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.4 GO:0061659 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 3.9 GO:0051015 actin filament binding(GO:0051015)
0.3 3.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.2 3.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 3.3 GO:0042393 histone binding(GO:0042393)
0.1 2.6 GO:0015485 cholesterol binding(GO:0015485)
0.1 2.4 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 2.3 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 2.2 GO:0042169 SH2 domain binding(GO:0042169)
0.7 2.1 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.1 2.0 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 1.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.7 GO:0030165 PDZ domain binding(GO:0030165)
0.5 1.6 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.3 1.6 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 1.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.5 GO:0017161 phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003)
0.0 1.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 1.2 GO:0002135 CTP binding(GO:0002135)
0.2 1.2 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)