Motif ID: E2f1

Z-value: 1.973


Transcription factors associated with E2f1:

Gene SymbolEntrez IDGene Name
E2f1 ENSMUSG00000027490.11 E2f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f1mm10_v2_chr2_-_154569720_1545697990.711.3e-04Click!


Activity profile for motif E2f1.

activity profile for motif E2f1


Sorted Z-values histogram for motif E2f1

Sorted Z-values for motif E2f1



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_106458440 7.391 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr2_-_34372004 7.308 ENSMUST00000113132.2
ENSMUST00000040638.8
 Pbx3

pre B cell leukemia homeobox 3

chrX_-_60893430 5.302 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr14_-_21989475 5.214 ENSMUST00000043409.7
 Zfp503
zinc finger protein 503
chrX_+_170009892 5.083 ENSMUST00000180251.1
 Gm21887
predicted gene, 21887
chrY_+_90784738 4.864 ENSMUST00000179483.1
 Erdr1
erythroid differentiation regulator 1
chr13_-_23761223 4.357 ENSMUST00000102964.2
 Hist1h4a
histone cluster 1, H4a
chr5_+_45669907 4.353 ENSMUST00000117396.1
 Ncapg
non-SMC condensin I complex, subunit G
chr15_-_98004634 4.349 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr13_+_113035111 4.250 ENSMUST00000180543.1
ENSMUST00000181568.1
ENSMUST00000109244.2
ENSMUST00000181117.1
ENSMUST00000181741.1
 Cdc20b




cell division cycle 20B




chr13_-_47106176 4.103 ENSMUST00000021807.6
ENSMUST00000135278.1
 Dek

DEK oncogene (DNA binding)

chr4_-_59549314 4.039 ENSMUST00000148331.2
ENSMUST00000030076.5
 Ptbp3

polypyrimidine tract binding protein 3

chr7_-_74554474 3.988 ENSMUST00000134539.1
ENSMUST00000026897.7
ENSMUST00000098371.2
 Slco3a1


solute carrier organic anion transporter family, member 3a1


chr6_+_146888481 3.910 ENSMUST00000016631.7
ENSMUST00000111623.2
 Ppfibp1

PTPRF interacting protein, binding protein 1 (liprin beta 1)

chr15_-_98004695 3.827 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr9_-_97018823 3.519 ENSMUST00000055433.4
 Spsb4
splA/ryanodine receptor domain and SOCS box containing 4
chr10_-_120476469 3.504 ENSMUST00000072777.7
ENSMUST00000159699.1
 Hmga2

high mobility group AT-hook 2

chr4_-_59549243 3.498 ENSMUST00000173699.1
ENSMUST00000173884.1
ENSMUST00000102883.4
ENSMUST00000174586.1
 Ptbp3



polypyrimidine tract binding protein 3



chr11_-_84525514 3.494 ENSMUST00000018842.7
 Lhx1
LIM homeobox protein 1
chr13_-_47105790 3.413 ENSMUST00000129352.1
 Dek
DEK oncogene (DNA binding)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 405 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 9.5 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.7 8.8 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.5 8.4 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.6 8.1 GO:0007076 mitotic chromosome condensation(GO:0007076)
1.9 7.6 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.5 7.5 GO:0043249 erythrocyte maturation(GO:0043249)
0.5 7.1 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.2 6.2 GO:0001709 cell fate determination(GO:0001709)
0.2 5.3 GO:0021854 hypothalamus development(GO:0021854)
1.7 5.2 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
1.0 5.1 GO:0046601 positive regulation of centriole replication(GO:0046601)
0.6 5.0 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.4 4.9 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.6 4.8 GO:0033504 floor plate development(GO:0033504)
0.4 4.8 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.5 4.7 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.0 4.4 GO:0006397 mRNA processing(GO:0006397)
1.4 4.3 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.4 4.3 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
1.0 4.0 GO:0046607 positive regulation of centrosome cycle(GO:0046607)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 194 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.5 GO:0005657 replication fork(GO:0005657)
0.1 10.2 GO:0044815 nucleosome(GO:0000786) DNA packaging complex(GO:0044815)
0.6 8.1 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
1.0 7.6 GO:0098536 deuterosome(GO:0098536)
0.0 7.6 GO:0000775 chromosome, centromeric region(GO:0000775)
0.9 6.5 GO:0000796 condensin complex(GO:0000796)
1.3 6.4 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 6.2 GO:0005814 centriole(GO:0005814)
0.1 6.1 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 5.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 5.0 GO:0043197 dendritic spine(GO:0043197)
0.0 4.3 GO:0000785 chromatin(GO:0000785)
0.1 4.1 GO:0043034 costamere(GO:0043034)
0.4 4.0 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 4.0 GO:0009925 basal plasma membrane(GO:0009925)
0.0 4.0 GO:0005923 bicellular tight junction(GO:0005923)
0.1 3.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 3.8 GO:0043292 contractile fiber(GO:0043292)
0.1 3.6 GO:0060077 inhibitory synapse(GO:0060077)
0.0 3.5 GO:0005681 spliceosomal complex(GO:0005681)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 233 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 24.0 GO:0042393 histone binding(GO:0042393)
0.0 14.9 GO:0044822 poly(A) RNA binding(GO:0044822)
0.1 13.8 GO:0008017 microtubule binding(GO:0008017)
0.1 11.6 GO:0001047 core promoter binding(GO:0001047)
0.2 8.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.5 8.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 7.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 7.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.3 6.4 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2 5.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.9 5.2 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.4 5.2 GO:0051010 microtubule plus-end binding(GO:0051010)
1.7 5.0 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 5.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.4 4.9 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.4 4.4 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.2 3.9 GO:0032794 GTPase activating protein binding(GO:0032794)
0.9 3.7 GO:0043515 kinetochore binding(GO:0043515)
0.1 3.7 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.2 3.4 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)