Motif ID: E2f2_E2f5
Z-value: 2.361
Transcription factors associated with E2f2_E2f5:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| E2f2 | ENSMUSG00000018983.9 | E2f2 |
| E2f5 | ENSMUSG00000027552.8 | E2f5 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2f2 | mm10_v2_chr4_+_136172367_136172395 | 0.73 | 8.6e-05 | Click! |
| E2f5 | mm10_v2_chr3_+_14578609_14578687 | 0.66 | 6.7e-04 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 170 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 29.6 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 0.3 | 15.7 | GO:0008156 | negative regulation of DNA replication(GO:0008156) |
| 1.2 | 12.2 | GO:0009186 | deoxyribonucleoside diphosphate metabolic process(GO:0009186) |
| 1.6 | 11.1 | GO:1990086 | lens fiber cell apoptotic process(GO:1990086) |
| 1.4 | 11.1 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 3.6 | 10.7 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 1.1 | 9.1 | GO:0033504 | floor plate development(GO:0033504) |
| 0.8 | 8.3 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.9 | 8.0 | GO:0090166 | Golgi disassembly(GO:0090166) |
| 0.1 | 6.4 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845) |
| 0.5 | 5.9 | GO:0006271 | DNA strand elongation involved in DNA replication(GO:0006271) |
| 0.1 | 5.9 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 1.4 | 5.4 | GO:0007056 | spindle assembly involved in female meiosis(GO:0007056) |
| 0.4 | 5.3 | GO:0090308 | regulation of methylation-dependent chromatin silencing(GO:0090308) |
| 1.3 | 5.0 | GO:0071139 | resolution of recombination intermediates(GO:0071139) |
| 0.1 | 4.8 | GO:0043550 | regulation of lipid kinase activity(GO:0043550) |
| 0.8 | 4.6 | GO:0046602 | regulation of mitotic centrosome separation(GO:0046602) |
| 0.0 | 4.6 | GO:0007018 | microtubule-based movement(GO:0007018) |
| 0.7 | 3.7 | GO:0019230 | proprioception(GO:0019230) |
| 0.6 | 3.5 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 95 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.8 | GO:0005667 | transcription factor complex(GO:0005667) |
| 2.6 | 12.9 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.1 | 10.8 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 8.7 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.1 | 7.5 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.2 | 7.4 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 1.2 | 7.1 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.6 | 6.4 | GO:0000800 | lateral element(GO:0000800) |
| 0.1 | 6.4 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.1 | 5.2 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 5.2 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.0 | 4.9 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.8 | 3.8 | GO:0035189 | Rb-E2F complex(GO:0035189) |
| 0.4 | 3.5 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.3 | 3.5 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.0 | 3.4 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.2 | 3.3 | GO:0001741 | XY body(GO:0001741) |
| 1.1 | 3.2 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.6 | 3.2 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.0 | 3.2 | GO:0005923 | bicellular tight junction(GO:0005923) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 109 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.7 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 23.7 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.0 | 17.1 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.2 | 13.6 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 2.6 | 12.9 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.0 | 11.7 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 11.2 | GO:0042393 | histone binding(GO:0042393) |
| 1.9 | 11.1 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.4 | 8.4 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.1 | 7.5 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.7 | 6.0 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 2.0 | 5.9 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 0.4 | 5.3 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.1 | 4.9 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.3 | 4.5 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.5 | 3.8 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.0 | 3.5 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.1 | 3.4 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.4 | 3.2 | GO:0008517 | folic acid transporter activity(GO:0008517) |
| 0.1 | 3.2 | GO:0030332 | cyclin binding(GO:0030332) |
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