Motif ID: E2f3

Z-value: 1.153


Transcription factors associated with E2f3:

Gene SymbolEntrez IDGene Name
E2f3 ENSMUSG00000016477.11 E2f3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f3mm10_v2_chr13_-_29984219_299843530.174.5e-01Click!


Activity profile for motif E2f3.

activity profile for motif E2f3


Sorted Z-values histogram for motif E2f3

Sorted Z-values for motif E2f3



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_137314394 7.083 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr11_-_100759942 4.636 ENSMUST00000107363.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr5_+_114568016 4.353 ENSMUST00000043650.7
 Fam222a
family with sequence similarity 222, member A
chr6_+_7555053 3.366 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr11_-_100759740 3.229 ENSMUST00000107361.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr5_-_45857473 3.210 ENSMUST00000016026.7
ENSMUST00000067997.6
ENSMUST00000045586.6
 Lcorl


ligand dependent nuclear receptor corepressor-like


chr19_+_53944870 2.619 ENSMUST00000025932.7
 Shoc2
soc-2 (suppressor of clear) homolog (C. elegans)
chr5_-_100719675 2.602 ENSMUST00000112908.1
ENSMUST00000045617.8
 Hpse

heparanase

chr10_+_50895651 2.578 ENSMUST00000020071.3
 Sim1
single-minded homolog 1 (Drosophila)
chr1_+_187609028 2.472 ENSMUST00000110939.1
 Esrrg
estrogen-related receptor gamma
chr19_+_41482632 2.272 ENSMUST00000067795.5
 Lcor
ligand dependent nuclear receptor corepressor
chr7_-_75309262 2.024 ENSMUST00000165175.1
 Sv2b
synaptic vesicle glycoprotein 2 b
chr2_+_109280738 1.981 ENSMUST00000028527.7
 Kif18a
kinesin family member 18A
chr4_+_46450892 1.859 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr18_+_11657349 1.837 ENSMUST00000047322.6
 Rbbp8
retinoblastoma binding protein 8
chr9_+_102717668 1.825 ENSMUST00000035121.7
 Amotl2
angiomotin-like 2
chr9_-_79793507 1.710 ENSMUST00000120690.1
 Tmem30a
transmembrane protein 30A
chr12_+_24708241 1.697 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr19_+_21778325 1.680 ENSMUST00000096194.2
ENSMUST00000025663.6
 Tmem2

transmembrane protein 2

chr3_+_69004969 1.676 ENSMUST00000136502.1
ENSMUST00000107803.1
 Smc4

structural maintenance of chromosomes 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.4 GO:0042391 regulation of membrane potential(GO:0042391)
1.1 3.4 GO:2000852 regulation of corticosterone secretion(GO:2000852)
0.6 3.3 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.6 3.2 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.9 2.6 GO:0030167 proteoglycan catabolic process(GO:0030167)
0.0 2.5 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 2.4 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.1 2.1 GO:0090161 Golgi ribbon formation(GO:0090161)
0.3 2.0 GO:0033504 floor plate development(GO:0033504)
0.4 1.8 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.2 1.8 GO:0031053 primary miRNA processing(GO:0031053)
0.0 1.8 GO:0035329 hippo signaling(GO:0035329)
0.2 1.7 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.4 1.6 GO:0071139 resolution of recombination intermediates(GO:0071139)
0.2 1.6 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 1.6 GO:0072520 seminiferous tubule development(GO:0072520)
0.0 1.6 GO:0000266 mitochondrial fission(GO:0000266)
0.0 1.5 GO:0033120 positive regulation of RNA splicing(GO:0033120)
0.1 1.4 GO:0048484 enteric nervous system development(GO:0048484)
0.3 1.3 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 4.6 GO:0000796 condensin complex(GO:0000796)
0.0 3.9 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 2.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 2.3 GO:0005871 kinesin complex(GO:0005871)
0.0 2.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.2 GO:0005814 centriole(GO:0005814)
0.1 2.1 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.3 2.0 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 1.8 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.3 1.7 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 1.7 GO:0043195 terminal bouton(GO:0043195)
0.3 1.6 GO:0000798 nuclear cohesin complex(GO:0000798) nuclear meiotic cohesin complex(GO:0034991)
0.0 1.6 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 1.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 1.3 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 1.2 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.2 1.0 GO:0000938 GARP complex(GO:0000938)
0.1 1.0 GO:0005675 holo TFIIH complex(GO:0005675)
0.0 1.0 GO:0072686 mitotic spindle(GO:0072686)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.9 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 7.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 3.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.9 2.6 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.1 2.6 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 2.5 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 2.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 2.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 2.0 GO:0051010 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) microtubule plus-end binding(GO:0051010)
0.0 2.0 GO:0003777 microtubule motor activity(GO:0003777)
0.2 1.9 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.4 1.8 GO:0001069 regulatory region RNA binding(GO:0001069)
0.3 1.7 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.4 1.6 GO:0036033 mediator complex binding(GO:0036033)
0.4 1.3 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001)
0.3 1.3 GO:0050062 long-chain-fatty-acyl-CoA reductase activity(GO:0050062) fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 1.3 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
0.0 1.3 GO:0003727 single-stranded RNA binding(GO:0003727)
0.2 1.2 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 1.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)