Motif ID: E2f4

Z-value: 0.859


Transcription factors associated with E2f4:

Gene SymbolEntrez IDGene Name
E2f4 ENSMUSG00000014859.8 E2f4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f4mm10_v2_chr8_+_105297663_1052977420.272.2e-01Click!


Activity profile for motif E2f4.

activity profile for motif E2f4


Sorted Z-values histogram for motif E2f4

Sorted Z-values for motif E2f4



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f4

PNG image of the network

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Top targets:


Showing 1 to 20 of 162 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_34751502 2.276 ENSMUST00000060710.7
 Cdc25c
cell division cycle 25C
chr14_-_47418407 2.250 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr1_-_169531343 2.070 ENSMUST00000028000.7
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr1_-_169531447 1.900 ENSMUST00000111368.1
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr19_+_6084983 1.834 ENSMUST00000025704.2
 Cdca5
cell division cycle associated 5
chr18_+_34751803 1.825 ENSMUST00000181453.1
ENSMUST00000181641.1
 2010110K18Rik

RIKEN cDNA 2010110K18 gene

chr9_-_32344237 1.824 ENSMUST00000034533.5
 Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
chr6_+_124830217 1.702 ENSMUST00000131847.1
ENSMUST00000151674.1
 Cdca3

cell division cycle associated 3

chr14_-_87141206 1.695 ENSMUST00000022599.7
 Diap3
diaphanous homolog 3 (Drosophila)
chr1_-_189688074 1.664 ENSMUST00000171929.1
ENSMUST00000165962.1
 Cenpf

centromere protein F

chr13_+_23535411 1.538 ENSMUST00000080859.5
 Hist1h3g
histone cluster 1, H3g
chr2_-_172940299 1.477 ENSMUST00000009143.7
 Bmp7
bone morphogenetic protein 7
chr14_-_87141114 1.472 ENSMUST00000168889.1
 Diap3
diaphanous homolog 3 (Drosophila)
chr8_-_53638945 1.340 ENSMUST00000047768.4
 Neil3
nei like 3 (E. coli)
chr10_-_88146867 1.257 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
 Parpbp



PARP1 binding protein



chr17_-_24251382 1.249 ENSMUST00000115390.3
 Ccnf
cyclin F
chr6_-_56704673 1.152 ENSMUST00000170382.2
 Lsm5
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr9_+_72438519 1.092 ENSMUST00000184604.1
 Mns1
meiosis-specific nuclear structural protein 1
chr13_-_73937761 1.017 ENSMUST00000022053.8
 Trip13
thyroid hormone receptor interactor 13
chr2_+_163054682 0.978 ENSMUST00000018005.3
 Mybl2
myeloblastosis oncogene-like 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.0 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.8 2.3 GO:0000087 mitotic M phase(GO:0000087)
0.3 2.0 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.6 1.8 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.1 1.8 GO:0070986 left/right axis specification(GO:0070986)
0.0 1.8 GO:0007052 mitotic spindle organization(GO:0007052)
0.1 1.7 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 1.7 GO:0051310 metaphase plate congression(GO:0051310)
0.0 1.7 GO:0000956 nuclear-transcribed mRNA catabolic process(GO:0000956)
0.4 1.6 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 1.6 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.1 1.6 GO:0010107 potassium ion import(GO:0010107)
0.5 1.5 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.1 1.5 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 1.3 GO:0006284 base-excision repair(GO:0006284)
0.2 1.2 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.1 1.2 GO:0008340 determination of adult lifespan(GO:0008340)
0.2 1.0 GO:0007144 female meiosis I(GO:0007144)
0.1 1.0 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.2 0.9 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 4.0 GO:0031262 Ndc80 complex(GO:0031262)
0.1 2.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.4 2.1 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 2.0 GO:0005882 intermediate filament(GO:0005882)
0.2 1.8 GO:0008278 cohesin complex(GO:0008278)
0.0 1.8 GO:0030315 T-tubule(GO:0030315)
0.1 1.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 1.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 1.3 GO:0001673 male germ cell nucleus(GO:0001673)
0.1 1.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 1.2 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 1.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.1 GO:0043198 dendritic shaft(GO:0043198)
0.2 1.0 GO:0031523 Myb complex(GO:0031523)
0.0 1.0 GO:0005643 nuclear pore(GO:0005643)
0.0 0.9 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 0.7 GO:0070531 BRCA1-A complex(GO:0070531)
0.1 0.7 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.7 GO:0000786 nucleosome(GO:0000786)
0.1 0.6 GO:0070695 FHF complex(GO:0070695)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 GO:0050699 WW domain binding(GO:0050699)
0.0 2.2 GO:0042393 histone binding(GO:0042393)
0.0 2.2 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.4 1.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 1.7 GO:0045502 dynein binding(GO:0045502)
0.3 1.6 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 1.5 GO:0070700 BMP receptor binding(GO:0070700)
0.3 1.3 GO:0000405 bubble DNA binding(GO:0000405)
0.1 1.0 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 1.0 GO:0036310 annealing helicase activity(GO:0036310)
0.0 1.0 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 0.9 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.7 GO:0003684 damaged DNA binding(GO:0003684)
0.1 0.6 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 0.5 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.1 0.4 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.1 0.4 GO:0052630 CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity(GO:0043338) phospholactate guanylyltransferase activity(GO:0043814) ATP:coenzyme F420 adenylyltransferase activity(GO:0043910) UDP-N-acetylgalactosamine diphosphorylase activity(GO:0052630)