Motif ID: E2f6

Z-value: 0.666


Transcription factors associated with E2f6:

Gene SymbolEntrez IDGene Name
E2f6 ENSMUSG00000057469.7 E2f6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f6mm10_v2_chr12_+_16810940_168109780.711.4e-04Click!


Activity profile for motif E2f6.

activity profile for motif E2f6


Sorted Z-values histogram for motif E2f6

Sorted Z-values for motif E2f6



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_60893430 2.600 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr5_+_139543889 2.573 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr6_-_23248264 2.259 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chrX_-_141725181 1.887 ENSMUST00000067841.7
 Irs4
insulin receptor substrate 4
chr11_+_82388900 1.818 ENSMUST00000054245.4
ENSMUST00000092852.2
 Tmem132e

transmembrane protein 132E

chr15_-_98004634 1.785 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr18_-_38211957 1.766 ENSMUST00000159405.1
ENSMUST00000160721.1
 Pcdh1

protocadherin 1

chr7_-_83884289 1.762 ENSMUST00000094216.3
 Mesdc1
mesoderm development candidate 1
chr2_-_64097994 1.683 ENSMUST00000131615.2
 Fign
fidgetin
chr15_-_98004695 1.612 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr13_+_112987802 1.539 ENSMUST00000038404.4
 Ccno
cyclin O
chr8_+_106935720 1.497 ENSMUST00000047425.3
 Sntb2
syntrophin, basic 2
chr2_-_117342709 1.486 ENSMUST00000173541.1
ENSMUST00000172901.1
ENSMUST00000173252.1
 Rasgrp1


RAS guanyl releasing protein 1


chr19_+_47014672 1.486 ENSMUST00000037636.3
 Ina
internexin neuronal intermediate filament protein, alpha
chr4_-_153482768 1.467 ENSMUST00000105646.2
 Ajap1
adherens junction associated protein 1
chr11_+_75193783 1.312 ENSMUST00000102514.3
 Rtn4rl1
reticulon 4 receptor-like 1
chr1_+_182763961 1.307 ENSMUST00000153348.1
 Susd4
sushi domain containing 4
chr7_-_81706905 1.304 ENSMUST00000026922.7
 Homer2
homer homolog 2 (Drosophila)
chr10_-_127534540 1.267 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr12_-_46818749 1.231 ENSMUST00000021438.6
 Nova1
neuro-oncological ventral antigen 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 304 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.8 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.2 3.6 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 2.4 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.6 2.3 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924)
0.5 2.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 2.3 GO:0007530 sex determination(GO:0007530)
0.5 2.1 GO:0003360 brainstem development(GO:0003360)
0.2 2.1 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.2 1.9 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.1 1.9 GO:0051383 kinetochore organization(GO:0051383)
0.6 1.8 GO:0072194 kidney smooth muscle tissue development(GO:0072194)
0.1 1.8 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.1 1.8 GO:0071625 vocalization behavior(GO:0071625)
0.1 1.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 1.7 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.5 1.5 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.4 1.5 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.1 1.5 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.0 1.5 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.3 1.4 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 131 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 GO:0031225 anchored component of membrane(GO:0031225)
0.2 3.0 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 3.0 GO:0016363 nuclear matrix(GO:0016363)
0.8 2.3 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.1 2.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 1.9 GO:0001741 XY body(GO:0001741)
0.0 1.9 GO:0032432 actin filament bundle(GO:0032432)
0.4 1.8 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 1.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 1.5 GO:0005883 neurofilament(GO:0005883)
0.1 1.4 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 1.4 GO:0031941 filamentous actin(GO:0031941)
0.3 1.3 GO:0032426 stereocilium tip(GO:0032426)
0.1 1.3 GO:0071565 nBAF complex(GO:0071565)
0.0 1.3 GO:0016234 inclusion body(GO:0016234)
0.0 1.3 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 1.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.2 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 1.0 GO:0030891 VCB complex(GO:0030891)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 187 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 3.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.4 2.3 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.2 2.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 2.0 GO:0043014 alpha-tubulin binding(GO:0043014)
0.4 1.8 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2 1.8 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.2 1.7 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 1.5 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0 1.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 1.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.3 1.4 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 1.4 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 1.4 GO:0008432 JUN kinase binding(GO:0008432)
0.0 1.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 1.3 GO:0005178 integrin binding(GO:0005178)
0.2 1.2 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.2 1.2 GO:0034056 estrogen response element binding(GO:0034056)
0.1 1.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)