Motif ID: E2f8

Z-value: 0.459


Transcription factors associated with E2f8:

Gene SymbolEntrez IDGene Name
E2f8 ENSMUSG00000046179.11 E2f8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f8mm10_v2_chr7_-_48881032_488810500.378.5e-02Click!


Activity profile for motif E2f8.

activity profile for motif E2f8


Sorted Z-values histogram for motif E2f8

Sorted Z-values for motif E2f8



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_40926220 0.929 ENSMUST00000034004.9
 Pdgfrl
platelet-derived growth factor receptor-like
chr1_-_128359610 0.444 ENSMUST00000027601.4
 Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr5_-_123749371 0.396 ENSMUST00000182955.1
ENSMUST00000182489.1
ENSMUST00000050827.7
 Rsrc2


arginine/serine-rich coiled-coil 2


chr5_-_123749393 0.371 ENSMUST00000057795.5
ENSMUST00000111515.1
ENSMUST00000182309.1
 Rsrc2


arginine/serine-rich coiled-coil 2


chr9_-_36726374 0.349 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
 Chek1


checkpoint kinase 1


chr11_+_77462325 0.329 ENSMUST00000102493.1
 Coro6
coronin 6
chr5_+_123749696 0.314 ENSMUST00000031366.7
 Kntc1
kinetochore associated 1
chr10_-_21160925 0.314 ENSMUST00000020158.6
 Myb
myeloblastosis oncogene
chr5_+_111581422 0.307 ENSMUST00000064930.3
 C130026L21Rik
RIKEN cDNA C130026L21 gene
chr5_+_137787769 0.304 ENSMUST00000035852.7
 Zcwpw1
zinc finger, CW type with PWWP domain 1
chr19_+_38931008 0.300 ENSMUST00000145051.1
 Hells
helicase, lymphoid specific
chr19_+_38930909 0.288 ENSMUST00000025965.5
 Hells
helicase, lymphoid specific
chr2_-_155945282 0.263 ENSMUST00000040162.2
 Gdf5
growth differentiation factor 5
chr16_-_18811615 0.262 ENSMUST00000096990.3
 Cdc45
cell division cycle 45
chr12_+_110279228 0.246 ENSMUST00000097228.4
 Dio3
deiodinase, iodothyronine type III
chr2_-_91236967 0.224 ENSMUST00000028696.4
 Ddb2
damage specific DNA binding protein 2
chr5_-_33652296 0.223 ENSMUST00000151081.1
ENSMUST00000101354.3
 Slbp

stem-loop binding protein

chr9_+_100643605 0.223 ENSMUST00000041418.6
 Stag1
stromal antigen 1
chr15_+_78926720 0.219 ENSMUST00000089377.5
 Lgals1
lectin, galactose binding, soluble 1
chr7_-_48881032 0.217 ENSMUST00000058745.8
 E2f8
E2F transcription factor 8
chr2_+_145785980 0.216 ENSMUST00000110005.1
ENSMUST00000094480.4
 Rin2

Ras and Rab interactor 2

chr11_+_79993062 0.207 ENSMUST00000017692.8
ENSMUST00000163272.1
 Suz12

suppressor of zeste 12 homolog (Drosophila)

chr13_+_44731265 0.203 ENSMUST00000173246.1
 Jarid2
jumonji, AT rich interactive domain 2
chr18_-_9726670 0.203 ENSMUST00000171339.1
 Gm17430
predicted gene, 17430
chr10_+_128015157 0.199 ENSMUST00000178041.1
ENSMUST00000026461.7
 Prim1

DNA primase, p49 subunit

chr13_+_44731281 0.194 ENSMUST00000174086.1
 Jarid2
jumonji, AT rich interactive domain 2
chr10_+_42860348 0.187 ENSMUST00000063063.7
 Scml4
sex comb on midleg-like 4 (Drosophila)
chr7_-_48881596 0.177 ENSMUST00000119223.1
 E2f8
E2F transcription factor 8
chr12_+_24708984 0.175 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr11_+_26387194 0.164 ENSMUST00000109509.1
ENSMUST00000136830.1
 Fancl

Fanconi anemia, complementation group L

chr7_+_110122299 0.164 ENSMUST00000033326.8
 Wee1
WEE 1 homolog 1 (S. pombe)
chr12_+_24708241 0.164 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr2_-_91236877 0.156 ENSMUST00000111352.1
 Ddb2
damage specific DNA binding protein 2
chr6_+_38551786 0.152 ENSMUST00000161227.1
 Luc7l2
LUC7-like 2 (S. cerevisiae)
chr17_+_56303321 0.148 ENSMUST00000001258.8
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr12_-_84450944 0.145 ENSMUST00000085192.5
 Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr15_-_98093245 0.143 ENSMUST00000180657.1
 Senp1
SUMO1/sentrin specific peptidase 1
chr15_+_55557575 0.139 ENSMUST00000170046.1
 Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr5_+_150673739 0.136 ENSMUST00000016569.4
ENSMUST00000038900.8
 Pds5b

PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)

chr15_+_55557399 0.134 ENSMUST00000022998.7
 Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr9_+_100643448 0.129 ENSMUST00000146312.1
ENSMUST00000129269.1
 Stag1

stromal antigen 1

chr2_-_34913976 0.124 ENSMUST00000028232.3
 Phf19
PHD finger protein 19
chr3_-_127553233 0.124 ENSMUST00000029588.5
 Larp7
La ribonucleoprotein domain family, member 7
chr1_+_131910458 0.122 ENSMUST00000062264.6
 Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr16_-_18248697 0.118 ENSMUST00000115645.3
 Ranbp1
RAN binding protein 1
chr4_+_132768325 0.114 ENSMUST00000102561.4
 Rpa2
replication protein A2
chr1_-_168431896 0.112 ENSMUST00000176540.1
 Pbx1
pre B cell leukemia homeobox 1
chr15_-_76090013 0.107 ENSMUST00000019516.4
 Nrbp2
nuclear receptor binding protein 2
chr2_+_163054682 0.106 ENSMUST00000018005.3
 Mybl2
myeloblastosis oncogene-like 2
chr16_+_10835046 0.103 ENSMUST00000037913.8
 Rmi2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chrX_+_152016428 0.099 ENSMUST00000045312.5
 Smc1a
structural maintenance of chromosomes 1A
chr17_+_56303396 0.099 ENSMUST00000113038.1
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr5_-_65335597 0.095 ENSMUST00000172660.1
ENSMUST00000172732.1
ENSMUST00000031092.8
 Rfc1


replication factor C (activator 1) 1


chr6_+_35177610 0.092 ENSMUST00000170234.1
 Nup205
nucleoporin 205
chrX_+_73716577 0.091 ENSMUST00000002084.7
 Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chr5_-_33652339 0.089 ENSMUST00000075670.6
 Slbp
stem-loop binding protein
chr12_+_55836365 0.086 ENSMUST00000059250.6
 Brms1l
breast cancer metastasis-suppressor 1-like
chr15_-_55557748 0.081 ENSMUST00000172387.1
 Mrpl13
mitochondrial ribosomal protein L13
chr9_+_103305156 0.080 ENSMUST00000035164.3
 Topbp1
topoisomerase (DNA) II binding protein 1
chr9_-_50659780 0.078 ENSMUST00000034567.3
 Dlat
dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
chrX_-_73716145 0.074 ENSMUST00000002091.5
 Bcap31
B cell receptor associated protein 31
chr16_+_20733104 0.073 ENSMUST00000115423.1
ENSMUST00000007171.6
 Chrd

chordin

chr6_+_21215472 0.072 ENSMUST00000081542.5
 Kcnd2
potassium voltage-gated channel, Shal-related family, member 2
chr11_+_21572221 0.069 ENSMUST00000020568.3
ENSMUST00000131135.1
 Wdpcp

WD repeat containing planar cell polarity effector

chrX_+_153498202 0.068 ENSMUST00000060714.8
 Ubqln2
ubiquilin 2
chr1_+_42229726 0.067 ENSMUST00000066196.1
 Gm9915
predicted gene 9915
chr10_+_84917616 0.066 ENSMUST00000038523.7
ENSMUST00000095385.3
 Ric8b

resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)

chr10_+_19356558 0.063 ENSMUST00000053225.5
 Olig3
oligodendrocyte transcription factor 3
chr2_-_157204483 0.063 ENSMUST00000029170.7
 Rbl1
retinoblastoma-like 1 (p107)
chr19_+_4756557 0.058 ENSMUST00000036744.7
 Rbm4b
RNA binding motif protein 4B
chr16_-_15637277 0.056 ENSMUST00000023353.3
 Mcm4
minichromosome maintenance deficient 4 homolog (S. cerevisiae)
chr7_+_102065485 0.055 ENSMUST00000106950.1
ENSMUST00000146450.1
 Trpc2

transient receptor potential cation channel, subfamily C, member 2

chr9_-_35116804 0.054 ENSMUST00000034537.6
 St3gal4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr4_-_129189512 0.053 ENSMUST00000117965.1
ENSMUST00000106061.2
ENSMUST00000072431.6
 S100pbp


S100P binding protein


chr4_-_129189646 0.051 ENSMUST00000106059.1
 S100pbp
S100P binding protein
chr13_+_19623163 0.050 ENSMUST00000002883.5
 Sfrp4
secreted frizzled-related protein 4
chr3_-_90695706 0.048 ENSMUST00000069960.5
ENSMUST00000117167.1
 S100a9

S100 calcium binding protein A9 (calgranulin B)

chr16_-_46496955 0.048 ENSMUST00000023335.6
ENSMUST00000023334.8
 Pvrl3

poliovirus receptor-related 3

chr16_+_15637844 0.048 ENSMUST00000023352.8
 Prkdc
protein kinase, DNA activated, catalytic polypeptide
chr5_+_135187251 0.045 ENSMUST00000002825.5
 Baz1b
bromodomain adjacent to zinc finger domain, 1B
chr1_-_168431695 0.045 ENSMUST00000176790.1
 Pbx1
pre B cell leukemia homeobox 1
chrX_-_41911877 0.041 ENSMUST00000047037.8
 Thoc2
THO complex 2
chr4_-_129189600 0.037 ENSMUST00000117497.1
ENSMUST00000117350.1
 S100pbp

S100P binding protein

chr7_-_128740471 0.035 ENSMUST00000119081.1
ENSMUST00000057557.7
 Mcmbp

MCM (minichromosome maintenance deficient) binding protein

chr6_+_108783059 0.035 ENSMUST00000032196.6
 Arl8b
ADP-ribosylation factor-like 8B
chr8_+_75109528 0.035 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr17_+_35236556 0.034 ENSMUST00000068261.8
 Atp6v1g2
ATPase, H+ transporting, lysosomal V1 subunit G2
chrX_+_73716712 0.031 ENSMUST00000114461.2
 Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chr7_-_44548733 0.029 ENSMUST00000145956.1
ENSMUST00000049343.8
 Pold1

polymerase (DNA directed), delta 1, catalytic subunit

chr7_-_115824699 0.027 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr5_-_137684665 0.027 ENSMUST00000100544.4
ENSMUST00000031736.9
ENSMUST00000151839.1
 Agfg2


ArfGAP with FG repeats 2


chr2_-_45113255 0.021 ENSMUST00000068415.4
ENSMUST00000127520.1
 Zeb2

zinc finger E-box binding homeobox 2

chr11_+_98907801 0.013 ENSMUST00000092706.6
 Cdc6
cell division cycle 6
chr5_-_65335564 0.010 ENSMUST00000172780.1
 Rfc1
replication factor C (activator 1) 1
chr11_+_88047693 0.003 ENSMUST00000079866.4
 Srsf1
serine/arginine-rich splicing factor 1
chr2_-_45112890 0.002 ENSMUST00000076836.6
 Zeb2
zinc finger E-box binding homeobox 2
chrX_-_70477170 0.001 ENSMUST00000101506.3
ENSMUST00000114630.2
 BC023829

cDNA sequence BC023829


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.1 0.3 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 0.6 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.1 0.5 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.1 0.7 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.1 0.2 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.1 0.3 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.1 0.4 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.1 0.3 GO:0060591 chondroblast differentiation(GO:0060591)
0.1 0.2 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.0 0.1 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.0 0.2 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.0 0.2 GO:0019336 phenol-containing compound catabolic process(GO:0019336)
0.0 0.1 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.0 0.3 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.3 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.0 0.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.2 GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0 0.1 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.1 GO:1904154 protein localization to endoplasmic reticulum exit site(GO:0070973) positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.0 0.2 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.0 0.1 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.0 0.1 GO:1902174 positive regulation of keratinocyte apoptotic process(GO:1902174)
0.0 0.0 GO:0070488 neutrophil aggregation(GO:0070488)
0.0 0.1 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0 0.1 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186) positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 0.1 GO:0097475 motor neuron migration(GO:0097475) spinal cord motor neuron migration(GO:0097476)
0.0 0.1 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.0 0.1 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1990423 RZZ complex(GO:1990423)
0.1 0.3 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 0.3 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 0.4 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.3 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.5 GO:0042555 MCM complex(GO:0042555)
0.0 0.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.1 GO:0031523 Myb complex(GO:0031523)
0.0 0.6 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.1 GO:0030893 meiotic cohesin complex(GO:0030893)
0.0 0.9 GO:0005657 replication fork(GO:0005657)
0.0 0.1 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.1 GO:1904115 axon cytoplasm(GO:1904115)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 0.3 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.1 0.2 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 0.3 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.1 0.2 GO:0005534 galactose binding(GO:0005534)
0.1 0.3 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.1 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.3 GO:0036122 BMP binding(GO:0036122)
0.0 0.2 GO:0052630 CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity(GO:0043338) phospholactate guanylyltransferase activity(GO:0043814) ATP:coenzyme F420 adenylyltransferase activity(GO:0043910) UDP-N-acetylgalactosamine diphosphorylase activity(GO:0052630)
0.0 0.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0036033 mediator complex binding(GO:0036033)
0.0 0.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.1 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.1 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.4 GO:0032452 histone demethylase activity(GO:0032452)