Motif ID: E2f8

Z-value: 0.459


Transcription factors associated with E2f8:

Gene SymbolEntrez IDGene Name
E2f8 ENSMUSG00000046179.11 E2f8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f8mm10_v2_chr7_-_48881032_488810500.378.5e-02Click!


Activity profile for motif E2f8.

activity profile for motif E2f8


Sorted Z-values histogram for motif E2f8

Sorted Z-values for motif E2f8



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f8

PNG image of the network

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Top targets:


Showing 1 to 20 of 97 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_40926220 0.929 ENSMUST00000034004.9
 Pdgfrl
platelet-derived growth factor receptor-like
chr1_-_128359610 0.444 ENSMUST00000027601.4
 Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr5_-_123749371 0.396 ENSMUST00000182955.1
ENSMUST00000182489.1
ENSMUST00000050827.7
 Rsrc2


arginine/serine-rich coiled-coil 2


chr5_-_123749393 0.371 ENSMUST00000057795.5
ENSMUST00000111515.1
ENSMUST00000182309.1
 Rsrc2


arginine/serine-rich coiled-coil 2


chr9_-_36726374 0.349 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
 Chek1


checkpoint kinase 1


chr11_+_77462325 0.329 ENSMUST00000102493.1
 Coro6
coronin 6
chr5_+_123749696 0.314 ENSMUST00000031366.7
 Kntc1
kinetochore associated 1
chr10_-_21160925 0.314 ENSMUST00000020158.6
 Myb
myeloblastosis oncogene
chr5_+_111581422 0.307 ENSMUST00000064930.3
 C130026L21Rik
RIKEN cDNA C130026L21 gene
chr5_+_137787769 0.304 ENSMUST00000035852.7
 Zcwpw1
zinc finger, CW type with PWWP domain 1
chr19_+_38931008 0.300 ENSMUST00000145051.1
 Hells
helicase, lymphoid specific
chr19_+_38930909 0.288 ENSMUST00000025965.5
 Hells
helicase, lymphoid specific
chr2_-_155945282 0.263 ENSMUST00000040162.2
 Gdf5
growth differentiation factor 5
chr16_-_18811615 0.262 ENSMUST00000096990.3
 Cdc45
cell division cycle 45
chr12_+_110279228 0.246 ENSMUST00000097228.4
 Dio3
deiodinase, iodothyronine type III
chr2_-_91236967 0.224 ENSMUST00000028696.4
 Ddb2
damage specific DNA binding protein 2
chr5_-_33652296 0.223 ENSMUST00000151081.1
ENSMUST00000101354.3
 Slbp

stem-loop binding protein

chr9_+_100643605 0.223 ENSMUST00000041418.6
 Stag1
stromal antigen 1
chr15_+_78926720 0.219 ENSMUST00000089377.5
 Lgals1
lectin, galactose binding, soluble 1
chr7_-_48881032 0.217 ENSMUST00000058745.8
 E2f8
E2F transcription factor 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.7 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.1 0.6 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.1 0.5 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.1 0.4 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.1 0.4 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.0 0.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 0.3 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 0.3 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.1 0.3 GO:0060591 chondroblast differentiation(GO:0060591)
0.0 0.3 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.3 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.1 0.2 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.1 0.2 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.0 0.2 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.0 0.2 GO:0019336 phenol-containing compound catabolic process(GO:0019336)
0.0 0.2 GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0 0.2 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.0 0.1 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.0 0.1 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.0 0.1 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 GO:0005657 replication fork(GO:0005657)
0.0 0.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.6 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.5 GO:0042555 MCM complex(GO:0042555)
0.1 0.4 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 0.3 GO:1990423 RZZ complex(GO:1990423)
0.1 0.3 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 0.3 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 0.3 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.1 GO:0031523 Myb complex(GO:0031523)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.1 GO:0030893 meiotic cohesin complex(GO:0030893)
0.0 0.1 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.1 GO:1904115 axon cytoplasm(GO:1904115)

Gene overrepresentation in molecular_function category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 GO:0032452 histone demethylase activity(GO:0032452)
0.1 0.3 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 0.3 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.1 0.3 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.1 0.3 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.3 GO:0036122 BMP binding(GO:0036122)
0.1 0.2 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 0.2 GO:0005534 galactose binding(GO:0005534)
0.0 0.2 GO:0052630 CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity(GO:0043338) phospholactate guanylyltransferase activity(GO:0043814) ATP:coenzyme F420 adenylyltransferase activity(GO:0043910) UDP-N-acetylgalactosamine diphosphorylase activity(GO:0052630)
0.0 0.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.1 GO:0036033 mediator complex binding(GO:0036033)
0.0 0.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.1 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.1 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)